KCNQ4 antibody

Principal name

KCNQ4 antibody

Alternative names for KCNQ4 antibody

KCNQ4, Voltage-gated potassium channel subunit Kv7.4, Potassium channel subunit alpha KvLQT4, KQT-like 4, Potassium voltage-gated channel subfamily KQT member 4

SwissProt ID

P56696 (Human), Q9JK96 (Rat), Q9JK97 (Mouse)

Gene ID

9132 (KCNQ4), 60613 (Kcnq4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of KCNQ4 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
Specifically, the protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (3), particularly in sensory cells of the cochlea (4). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anticonvulsant drug (5).

General readings

Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Geleoc GS, Edge A, Holt JR, Heller S.
Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.
J Assoc Res Otolaryngol. 2007 Mar;8(1):18-31. Epub 2006 Dec 14.
PMID: 17171473

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNQ4 antibody

  Goat Anti-KCNQ4 Antibody  
TA305760 (2ug/ml) staining of Cerebellum lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ4 antibody

  Rabbit polyclonal anti-KCNQ4 antibody  
Western blot analysis of extracts from HuvEc cells, using KCNQ4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNQ4 antibody

  Mouse monoclonal KCNQ4 Antibody  
Western blot analysis of KCNQ4 in rat tissue lysates using a 1:1000 dilution of the antibody Mouse IgG1 S43-6 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNQ4 antibody

  Rabbit Polyclonal Anti-KCNQ4 Antibody  
WB Suggested Anti-KCNQ4 Antibody Titration: 0.2-1 ug/ml; Positive Control: HT1080 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KCNQ4 antibody

  Rabbit Polyclonal Anti-KCNQ4 Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: (KCNQ4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 7 minutes Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KCNQ4 antibody

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM (left lane) and COS-1 cells transiently transfected with KCNQ4 (middle lane) or Kv2.1 (right lane) plasmids and probed with pure N43/6 (left panel) or K89/41 TC supe (right panel). Mouse IgG1 N43/6 Supernatant Hu, Ms, Rt ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNQ4 antibody

Mouse cochlea immunofluorescence. Left panel is labeling in crista ampullaris, right panel in outer hair cells in organ of Corti. Red = N43/6, Blue = Hoechst nuclear stain. Courtesy of Ms. Gesa Rickheit and Dr. Thomas Jentsch, Max-Delbrueck-Centrum fuer Molekulare Medizin, Berlin, Germany. Mouse IgG1 N43/6 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNQ4 antibody

KCNQ4 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

KCNQ4 - human gene knockout kit via CRISPR

KCNQ4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KCNQ4 - human gene knockout kit via CRISPR

KCNQ4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNQ4 - human gene knockout kit via CRISPR

KCNQ4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KCNQ4 - human gene knockout kit via CRISPR

KCNQ4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnq4 - mouse gene knockout kit via CRISPR

Kcnq4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kcnq4 - mouse gene knockout kit via CRISPR

Kcnq4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnq4 - mouse gene knockout kit via CRISPR

Kcnq4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kcnq4 - mouse gene knockout kit via CRISPR

Kcnq4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KCNQ4 (transcript variant 2)

  Recombinant protein of human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2  
KCNQ4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KCNQ4 (mGFP-tagged) - Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNQ4 (mGFP-tagged) - Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,300.00
  OriGene Technologies, Inc.

Lenti ORF particles, KCNQ4 (Myc-DDK tagged) - Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, KCNQ4 (Myc-DDK tagged) - Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kcnq4 (GFP-tagged) - Mouse potassium voltage-gated channel, subfamily Q, member 4 (Kcnq4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kcnq4 (GFP-tagged) - Mouse potassium voltage-gated channel, subfamily Q, member 4 (Kcnq4), 200 uL, >10^7 TU/mL  
200 µl / €1,380.00
  OriGene Technologies, Inc.

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