KCNT2 / SLICK antibody

Principal name

KCNT2 / SLICK antibody

Alternative names for KCNT2 / SLICK antibody

Slo2.1, Potassium channel subfamily T member 2, Sequence like an intermediate conductance potassium channel subunit, Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1

SwissProt ID

Q6UVM3 (Human), Q6UVM4 (Rat)

Gene ID

343450 (KCNT2), 304827 (Kcnt2), 240776

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of KCNT2 / SLICK antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Slo2.1 is a novel member of the mammalian Slo potassium channel gene family (3). The slick channel is activated by intracellular Na+ and Cl- and is inhibited by intracellular ATP. It is also widely expressed in the CNS and detected in the heart (4).

General readings

Santi, C.M., et al. J. Neurosci. 26(19):5059-5068(2006)
Wei, A.D., et al. Pharmacol. Rev. 57(4):463-472(2005)
Bhattacharjee, A., et al. J. Neurosci. 23(37):11681-11691(2003)

7 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KCNT2 / SLICK (564-624) antibody

Western blot analysis of Slo2.1 (SLICK) in rat brain membrane lysates using a 1:1000 dilution of TA309478. Mouse IgG1 S11-33 Purified Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KCNT2 / SLICK antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-KCa4.2 (Slick) antibody , (1:200). 3, 4. Anti-KCa4.2 (Slick) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

KCNT2 / SLICK antibody

Immunoblot against brain membranes from adult rat (RBM) or from Slo2.1 knockout (MBM-Slo2.1 KO) or wild-type (MBM-WT) mice probed with N11/33 (left) or N52A/42 (right) TC supe. Mouse brains courtesy of Chris Lingle (Washington University). Mouse IgG1 N11/33 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

KCNT2 / SLICK antibody

Immunoblot against brain membranes from adult rat (RBM) or from Slo2.1 knockout (MBM-Slo2.1 KO) or wild-type (MBM-WT) mice probed with N11/33 (left) or N52A/42 (right) TC supe. Mouse brains courtesy of Chris Lingle (Washington University). Mouse IgG1 N11/33 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

KCNT2 / SLICK (C-term) antibody

immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with KCNT2 / SLICK Antibody (C-term) Cat.-No AP52320PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KCNT2 / SLICK antibody

KCNT2 / SLICK Rabbit Serum Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

KCNT2 / SLICK antibody

KCNT2 / SLICK Mouse S11-33 Purified Ms, Rt P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

7 Item(s)

per page
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