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KCNV2 antibody

Principal name

KCNV2 antibody

Alternative names for KCNV2 antibody

KV11.1, Kv8.2, Potassium voltage-gated channel subfamily V member 2

SwissProt ID

Q8CFS6 (Mouse), Q8TDN2 (Human)

Gene ID

169522 (KCNV2), 240595 (Kcnv2)

Ncbi ID

NP_598004, NP_598004.1, NP_899002.1, NM_183179, NM_133497

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KCNV2 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a \'silent subunit\', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. KCNV2 is strongly expressed in pancreas and has a weaker expression in several other tissues.Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a \'silent subunit\', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues.

General readings

Robson, A.G., et al. Retina (Philadelphia, Pa.) 30(1):51-62(2010)
Ben Salah, S., et al. Am. J. Ophthalmol. 145(6):1099-1106(2008)
Wissinger, B., et al. Invest. Ophthalmol. Vis. Sci. 49(2):751-757(2008)
Thiagalingam, S., et al. Ophthalmic Genet. 28(3):135-142(2007)
Balijepalli, R.C., et al. Channels (Austin) 1(4):263-272(2007)

Human 293T; WB Suggested Anti-KCNV2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: 293T cell lysate; KCNV2 antibody - N-terminal region (ARP35396_P050) in Human 293T cells using Western Blot

ARP35396_P050

Western blot analysis of extracts from MCF-7 cells, using KCNV2 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue reacted with KCNV2 Antibody (C-term) Cat.-No AP52321PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining.

AP52321PU-N

Western blot analysis of KCNV2 Antibody (C-term) Cat.-No AP52321PU-N in 293, K562, HepG2, Jurkat, ZR-75-1 cell line lysates (35ug/lane). This demonstrates the KCNV2 antibody detected the KCNV2 protein (arrow).

AP52321PU-N

Western blot analysis of extracts from Jurkat cells, using OR4K3 antibody.The lane on the right is treated with the synthesized peptide.

TA316201

Immunofluorescence analysis of A549 cells, using OR4K3 antibody.The picture on the right is treated with the synthesized peptide.

TA316201

WB Suggested Anti-KCNV2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: 293T cell lysate

TA338726

Western blot analysis of Kv8.2 expression in mouse brain (A); rat brain (B) whole cell lysates.

Immunohistochemical analysis of Kv8.2 staining in mouse brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA316201	KCNV2 antibody
	Rabbit polyclonal anti-OR4K3 antibody
	Rabbit	IgG	Purified	Hu	E, ICC/IF, WB	0.1 ml / €335.00
						OriGene Technologies, Inc.
+1 additional image
TA338726	KCNV2 antibody
	Rabbit Polyclonal Anti-KCNV2 Antibody
	Rabbit	IgG	Purified	Hu, Por	WB	50 µg / €360.00
						OriGene Technologies, Inc.
AP52321PU-N	KCNV2 (C-term) antibody
	Rabbit	Ig	Aff - Purified	Hu	P, WB	0.4 ml / €370.00
						Acris Antibodies GmbH
+1 additional image
C17829-1	KCNV2 antibody
	Rabbit		Aff - Purified	Hu, Ms	E, WB	50 µg / €230.00
						Assay Biotech
C17829-2	KCNV2 antibody
	Rabbit		Aff - Purified	Hu, Ms	E, WB	0.1 mg / €330.00
						Assay Biotech

CRISPR

Catalog No.	Species	Donor Vector
KN308699	Kcnv2 - mouse gene knockout kit via CRISPR
	Mouse	GFP-Puro	1 kit / €1,290.00
			OriGene Technologies, Inc.
KN308699BN	Kcnv2 - mouse gene knockout kit via CRISPR
	Mouse	mBFP-Neo	1 kit / €1,290.00
			OriGene Technologies, Inc.
KN308699LP	Kcnv2 - mouse gene knockout kit via CRISPR
	Mouse	Luciferase-Puro	1 kit / €1,290.00
			OriGene Technologies, Inc.
KN308699RB	Kcnv2 - mouse gene knockout kit via CRISPR
	Mouse	RFP-BSD	1 kit / €1,290.00
			OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.
RC216308L2V	Lenti ORF particles, KCNV2 (mGFP-tagged) - Human potassium channel, subfamily V, member 2 (KCNV2), 200 uL, >10^7 TU/mL
		200 µl / €1,082.00
		OriGene Technologies, Inc.

RC216308L1V	Lenti ORF particles, KCNV2 (Myc-DDK tagged) - Human potassium channel, subfamily V, member 2 (KCNV2) , 200 uL, >10^7 TU/mL
		200 µl / €969.00
		OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.
MR208914L2V	Lenti ORF particles, Kcnv2 (GFP-tagged) - Mouse potassium channel, subfamily V, member 2 (Kcnv2), 200 uL, >10^7 TU/mL
		200 µl / €1,247.00
		OriGene Technologies, Inc.

MR208914L1V	Lenti ORF particles, Kcnv2 (Myc-DDK-tagged) - Mouse potassium channel, subfamily V, member 2 (Kcnv2), 200 uL, >10^7 TU/mL
		200 µl / €1,113.00
		OriGene Technologies, Inc.

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