Keratocan antibody

Principal name

Keratocan antibody

Alternative names for Keratocan antibody

KERA, SLRR2B, Keratan sulfate proteoglycan keratocan, KTN, Keratocan

SwissProt ID

O35367 (Mouse), O42235 (Chick), O60938 (Human), O62702 (Bovin), Q9DE66 (Cotja)

Gene ID

11081 (KERA)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Keratocan antibody

Small leucine-rich proteoglycans (SLRPs) such as Decorin, Biglycan, Fibromod-ulin, Keratocan, Lumican and Osteoglycin mediate extracellular matrix organization and are binding partners of TGF Beta. The Decorin core protein binds to growth factors, intercellular matrix molecules such as Fibronectin and Throm-bospondin, and to the Decorin endocytosis receptor. Fibromodulin is a collagen-binding keratan sulphate proteoglycan that influences adhesion processes of connective tissue and plays a role in fibrillogenesis by regulating collagen fibril spacing and thickness. Keratocan (KTN) develops corneal transparency and maintains the stromal matrix structure. Keratocan is a secreted protein in the extracellular matrix that binds to keratan sulfate chains. Keratocan is mainly detected in the cornea, but can also be expressed in trachea, intestine, ovary, lung and skeletal muscle. Defects in the gene encoding for Keratocan can cause cornea plana 2 (CNA2), an autosomal recessive disorder where the forward convex curvature of the cornea is flattened.

General readings

Aldave, A.J., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4006-4012(2010)
Dimasi, D.P., et al. Mol. Vis. 16, 562-569 (2010)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009)
Melrose, J., et al. Arthritis Res. Ther. 10 (4), R79 (2008)
Liskova, P., et al. Mol. Vis. 13, 1339-1347 (2007)

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Keratocan (C-term) antibody

Keratocan Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Keratocan antibody

Keratocan Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Keratocan antibody

Keratocan Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  


Keratocan Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.


Keratocan Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

5 Item(s)

per page
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