Ki-67 antibody

Principal name

Ki-67 antibody

Alternative names for Ki-67 antibody

Ki67 antigen, MKI67, Proliferation marker

SwissProt ID

P46013 (Human)

Gene ID

4288 (MKI67)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Por (Porcine), Bov (Bovine)

Available hosts

Mouse, Rabbit, Rat

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F), Immunoprecipitation (IP)

Background of Ki-67 antibody

Origilly discovered employing mouse monoclol antibody against a nuclear antigen from Hodgkin's lymphoma-derived cell line, this non-histone protein was med Ki67 after researcher's location (Gerdes and colleagues), Ki for Kiel University in Germany and 67 referring to the clone number on the 96-well plate. It interacts with KIF15 as well as MKI67IP, and is suggested to be involved in cell cycle regulation. Ki67 is a large protein with expected molecular weight of about 395 kD and has a very complex localization pattern within the nucleus, one which changes during cell cycle progression. Its expression occurs specially during late G1, S, G2 and M phases of the cell cycle, while in cells undergoing G0 phase, Ki67 remains undetectable. Ki67 undergoes phosphorylation/dephosphorylation during mitosis, is susceptible to proteases and its structure implies that its expression is regulated by proteolytic pathways. Ki67 is associated with nucleolar DFC (dense fibrillary component) and its regulation appears to be tightly controlled (estimated half life is 60-90 min, regardless of the cell position in the cell cycle), presumably by precise synthesis and degradation systems involving proteasome, a protease complex. Due to its association with cell divison process, Ki-67 is routinely used as cellular proliferation marker of solid tumors as well as certain hematological maligncies, and a correlation has been demonstrated between Ki-67 index and the histopathological grade of cancers.

General readings

General / background references:Wharton SB et al. Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology. Neurosci Lett 383:33-8 (2005). PubMed PMID: 15936508
Dudderidge TJ et al. Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma. Clin Cancer Res 11:2510-7 (2005). PubMed PMID: 15814627

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MKI67 rat monoclonal antibody. (TA801577; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Rat IgG1 OTI5D7 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 (C-term) antibody

Formalin-fixed, paraffin-embedded human tonsil stained with Ki-67 antibody (Cat.-No DRM004) using peroxidase-conjugate and AEC. Note nuclear staining of proliferating cells. Rabbit IgG SP6 Supernatant Hu, Ms P
0.5 ml / €380.00
  Acris Antibodies GmbH

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded normal human tonsil tissue using anti-MKI67 mouse monoclonal antibody. (UM800033 at 1ug/ml for 30 min at RT; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 20min; ) Mouse IgG2a UMAB107 Purified Hu ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded normal human tonsil tissue using anti-MKI67 mouse monoclonal antibody. (UM800033 at 1ug/ml for 30 min at RT; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 20min; ) Mouse IgG2a UMAB107 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-MKI67 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500265, Dilution 1:50) Mouse IgG2b OTI3D11 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemistry: Ki67 Antibody [TA336566] - Detection of Ki67 in formalin-fixed paraffin embedded mouse intestine using TA336566. Rabbit Purified Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ki-67 antibody

Immunohistochemistry: Ki67 Antibody [TA336567] - Detection of Ki67 in formalin-fixed paraffin embedded mouse intestine using TA336567. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ki-67 antibody

Immunohistochemistry: Ki67 Antibody [TA336568] - Detection of human lymph node using TA336568. (20X) Rabbit Purified Hu, Ms C, ICC/IF, P
50 µl / €325.00
  OriGene Technologies, Inc.

Ki-67 antibody

Western Blot: Ki67 Antibody [TA336650] - Western blot analysis of A431 (A) and Hek293 (B) cell lysate using Ki67 antibody (TA336650) at 2 ug/ml. Rabbit IgG Purified Hu, Ms, Por, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MKI67 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800648) Mouse IgG1 OTI8H5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-MKI67 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800649) Mouse IgG1 OTI3B8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MKI67 rat monoclonal antibody. (TA801155; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Rat IgG1 OTI5B10 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MKI67 rat monoclonal antibody. (TA801156; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Rat IgG1 OTIC3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MKI67 rat monoclonal antibody. (TA801343; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Rat IgG1 OTI3B6 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-MKI67 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801745) Rat IgG1 OTI5D5 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-MKI67 rat monoclonal antibody. (TA801828; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Rat IgG2a OTI1D9 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-MKI67 rat monoclonal antibody. (TA801829; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Rat IgG2a OTI3A11 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MKI67 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802426) Mouse IgG1 OTI1F11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MKI67 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802429) Mouse IgG1 OTI15A4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Ki-67 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MKI67 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802431) Mouse IgG1 OTI9H1 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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