KLK14 / Kallikrein-14 antibody

Principal name

KLK14 / Kallikrein-14 antibody

Alternative names for KLK14 / Kallikrein-14 antibody

KLKL6, KLK-L6, Kallikrein-like protein 6

SwissProt ID

Q9P0G3 (Human)

Gene ID

43847 (KLK14)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of KLK14 / Kallikrein-14 antibody

The human tissue Kallikrein gene family encodes 15 serine proteases. All Kallikreins share structural similarities including cysteine residues, a catalytic triad of His, Asp and Ser residues, typically five coding exons, and varied intron phases. Kallikreins are predominantly secreted as inactive zymogens prior to activation by cleavage of an N-terminal peptide and all function extracellularly. Kallikreins can be activated autocatalytically, via other Kallikreins, or additional proteases. While structurally similar, Kallikrein family members have distinct functions and have key roles in many physiological and pathological processes. Many human tissue Kallikreins also show promise as cancer biomarkers, which may facilitate earlier detection and characterization of many forms of cancer. Kallikrein 14, also known as kallikrein-like6 (KLK-L6), is a trypsin-like serine proteinase. Kallikrein 14 was discovered by cloning the kallikrein locus on chromosome 19 and was found to be similar to the other kallikrein family genes. Kallikrein 14 is produced by a number of tissues, including the brain, spinal cord, esophagus, salivary gland, breast, prostate, uterus, lung, thymus and thyroid. Like many of the kallikreins, Kallikrein 14 is also found in biological fluids like serum, breast milk, amniotic fluid, seminal plasma and cerebrospinal fluid. Kallikrein 14 message has been reported to be decreased in some breast cancers and in ovarian cancers, similar to Kallikrein 10. Some cell lines express Kallikrein 14 in culture and like many of the kallikreins, the production is stimulated by hormones. Recombinant kallikrein 14 was profiled on peptide substrates and found to possess both trypsin-like and chymotrypsin-like activity. The ECM proteins lamanin and collagen-IV are thought to be substrates of Kallikrein 14. Endogenous inhibitors include kallistatin, protein-C inhibitor and alpha1-proteinase inhibitor, although Kallikrein 14 can be found complexed to a number of different proteinase inhibitors.

General readings

Klein, R.J., et al. Cancer Prev Res (Phila Pa) 3(5):611-619(2010)
Hashem, N.N., et al. Int. J. Biol. Markers 25(1):32-37(2010)
Emami, N., et al. Biol. Chem. 390(9):921-929(2009)
Lai, J., et al. Mol. Cancer Res. 7(1):129-141(2009)
Paliouras, M., et al. Mol Oncol 1(4):413-424(2008)

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KLK14 / Kallikrein-14 antibody

Western Blot: KLK 14 Antibody - Western Blot detection of KLK14 (also known as KLK-L6) in BT-474 cells using anti- KLK14 at a 1:1000 dilution. Rabbit IgG Purified Hu C, E, IP
0.1 mg / €325.00
  OriGene Technologies, Inc.

KLK14 / Kallikrein-14 antibody

Western blot analysis of fetal liver lysates with anti-Kallikrein 14 antibody (1:100). Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KLK14 / Kallikrein-14 antibody

Figure 1. AP20016PU-N Kallikrein-14/KLK14 antibody staining of Palmar Skin. The KLK14 antibody stains intraepidermal sweat ducts. Rabbit Aff - Purified Hu C, P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

KLK14 / Kallikrein-14 (N-term) antibody

Western blot analysis of KLK14 Antibody (N-term) Cat.-No AP52392PU-N in NCI-H292 cell line lysates (35ug/lane). This demonstrates the KLK14 antibody detected the KLK14 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KLK14 / Kallikrein-14 antibody

Western Blot analysis of KLK14 expression in transfected 293T cell line (H00043847-T01) by KLK14 MaxPab polyclonal antibody.

Lane 1: KLK14 transfected lysate(27.61 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

KLK14 / Kallikrein-14 antibody

KLK14 / Kallikrein-14 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

KLK14 / Kallikrein-14 antibody

KLK14 / Kallikrein-14 Mouse IgG2b 2A7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

KLK14 / Kallikrein-14 antibody

Western blot of 10 µl conditional medium using KLK14 polyclonal antibody 1 : 1000. The anti-rabbit antibody is conjugated to AP : 
1 ) Denatured protein. 
2 ) Native protein. The samples are from recombinant human KLK14 protein produced in eukaryotic yeast Pichia pastoris. Samples were separated. Rabbit IgG Purified Hu P, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

KLK14 / Kallikrein-14 antibody

KLK14 / Kallikrein-14 Rabbit Aff - Purified Hu C, P, WB
0.1 mg / €420.00
  AgriSera AB

KLK14 / Kallikrein-14 antibody

KLK14 / Kallikrein-14 Rabbit Aff - Purified Hu WB
0.1 mg / €330.00
  Neuromics Antibodies

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KLK14 / Kallikrein-14

KLK14 / Kallikrein-14 Human
2 µg / €300.00
  Abnova Taiwan Corp.

KLK14 / Kallikrein-14

KLK14 / Kallikrein-14 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KLK14 / Kallikrein-14

KLK14 / Kallikrein-14 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ELISA Kits

Catalog No.    

Human Kallikrein 14 ELISA Kit

Representative Standard Curve  
96 Tests / €450.00
  Cohesion Biosciences Ltd.

Lysates

Catalog No.    

Kallikrein-14 / KLK14 Lysate(Denatured)

Kallikrein-14 / KLK14 Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

15 Item(s)

per page
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