KLK8 / Kallikrein-8 antibody

Principal name

KLK8 / Kallikrein-8 antibody

Alternative names for KLK8 / Kallikrein-8 antibody

Neuropsin, Ovasin, NRPN, PRSS19, TADG14, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, Serine protease 19

SwissProt ID

O60259 (Human), O88780 (Rat), Q61955 (Mouse), Q9UQ47 (Human)

Gene ID

11202 (KLK8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Luminex (LMNX), Flow Cytometry (F)

Background of KLK8 / Kallikrein-8 antibody

Kallikrein 8 (hK8), also known as neuropsin, brain serine protease 1 (BSP1), tumor associated differentially expressed gene 14 (TADG14), PRSS19, HNP and ovasin, is a trypsin like serine protease. Originally described from mouse brain, KLK8 was implicated in neural plasticity and learning. Kallikrein 8 is thought to be involved in neurite outgrowth and fasciculation during nervous system development. Kallikrein 8 is induced in neurite injury, and Kallikrein 8 has been shown to be elevated in the hippocampus on Alzheimer’s patients’ brains. Animal models of autoimmune encephalomyelitis (EAE) show elevated Kallikrein 8 production. Kallikrein 8 null mice have aberrant synapses in their hippocampus, compared to wild type mice, and are predisposed to seizures. Kallikrein 8 is thought to regulate the early phase of long-term potentiation (LTP), possibly by cleaving fibronectin and other substrates. Kallikrein 8 is also found in the uterus, where it is hormonally regulated. Cervical cancer cell lines express high levels of Kallikrein 8, and it may be useful as a tumor marker. Kallikrein 8 is not limited to the brain and uterus, as many tissues and cell lines make the protein. Endogenous inhibitors include serine protease inhibitor 3 and protein C inhibitor, although Kallikrein 8 can be found complexed to a number of different protease inhibitors.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-KLK8 mouse monoclonal antibody. (UM500068; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB84 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human skin tissue using anti-KLK8 mouse monoclonal antibody. (UM500069; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB85 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-KLK8 mouse monoclonal antibody. (UM500068; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB84 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human skin tissue using anti-KLK8 mouse monoclonal antibody. (UM500069; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB85 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506100) Mouse IgG1 OTIH6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506110) Mouse IgG1 OTIB1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506124) Mouse IgG2a OTI1D2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506135) Mouse IgG2b OTI10D3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506138) Mouse IgG1 OTI3C10 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506159) Mouse IgG1 OTI5B4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506171) Mouse IgG2a OTI2C6 Purified Can, Hu, Mky ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506172) Mouse IgG2a OTI16G2 Purified Can, Hu, Mky ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506173) Mouse IgG1 OTI8F1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506176) Mouse IgG2b OTI2A5 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

KLK8 / Kallikrein-8 antibody

Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

KLK8 / Kallikrein-8 antibody

KLK8 Elisa with 5B1 Capture (TA600204) and 10D3 Detection (TA700200) Antibodies. Substrate used: Recombinant Human KLK8 (TP308152) Mouse IgG1 OTI5B1 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

KLK8 / Kallikrein-8 antibody

KLK8 Elisa with 3C10 Capture (TA600206) and 10D3 Detection (TA700200) Antibodies. Substrate used: Recombinant Human KLK8 (TP308152) Mouse IgG1 OTI3C10 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

KLK8 / Kallikrein-8 antibody

KLK8 Elisa with 14G10 Capture (TA600207) and 10D3 Detection (TA700200) Antibodies. Substrate used: Recombinant Human KLK8 (TP308152) Mouse IgG1 OTI14G10 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

KLK8 / Kallikrein-8 antibody

KLK8 Elisa with 14G10 Capture (TA600207) and 10D3 Detection (TA700200) Antibodies. Substrate used: Recombinant Human KLK8 (TP308152) Mouse IgG2b OTI10D3 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

KLK8 / Kallikrein-8 antibody

KLK8 Elisa with 3C10 Capture (TA600206) and 1D2 Detection (TA700200) Antibodies. Substrate used: Recombinant Human KLK8 (TP308152) Mouse IgG2a OTI1D2 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

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