KLKB1 / Kininogen antibody

Principal name

KLKB1 / Kininogen antibody

Alternative names for KLKB1 / Kininogen antibody

Plasma kallikrein, Fletcher factor

SwissProt ID

P03952 (Human), P14272 (Rat), P26262 (Mouse), Q2KJ63 (Bovin)

Gene ID

3818 (KLKB1), 25048 (Klkb1)

Available reactivities

Hu (Human), Por (Porcine), Chimp (Chimpanzee), Mky (Monkey), Rt (Rat), Ms (Mouse), Can (Canine), Eq (Equine), Bov (Bovine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Sheep, Goat

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunodiffusion (ID), Immunoprecipitation (IP)

Background of KLKB1 / Kininogen antibody

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

General readings

Tang,J., (2005) J. Biol. Chem. 280 (49), 41077-41089

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KLKB1 / Kininogen antibody

  Rabbit polyclonal KLKB1 (heavy chain, Cleaved-Arg390) antibody  
Western blot analysis of extracts from HeLa cells, using KLKB1 (heavy chain, Cleaved-Arg390) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KLKB1 / Kininogen antibody

  Rabbit anti-KLKB1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using KLKB1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

KLKB1 / Kininogen antibody

  Rabbit Polyclonal Anti-KLKB1 Antibody  
WB Suggested Anti-KLKB1 Antibody Titration: 2.5 ug/ml; Positive Control: Human Liver Rabbit IgG Purified Can, Eq, Hu, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KLKB1 / Kininogen antibody

  Rabbit Polyclonal Anti-Klkb1 Antibody  
WB Suggested Anti-Klkb1 Antibody; Titration: 1.0 ug/ml; Positive Control: Rat Brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KLKB1 / Kininogen antibody

Human Small Intestine, Vessels (formalin-fixed, paraffin-embedded) stained with KLKB1 antibody AP22821PU-N at 5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Sheep IgG Ig Fraction Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

KLKB1 / Kininogen antibody

KLKB1 / Kininogen Goat Serum Hu ID, IP
1 ml / €380.00
  Acris Antibodies GmbH

KLKB1 / Kininogen antibody

KLKB1 / Kininogen Mouse IgG1 901 Azide Free Hu E, FN, WB
0.2 mg / €980.00
  Acris Antibodies GmbH

KLKB1 / Kininogen antibody

KLKB1 / Kininogen Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

KLKB1 / Kininogen (heavy chain) antibody

KLKB1 / Kininogen Mouse IgG1 901 Chimp, Hu, Mky E, WB
0.2 mg / €990.00
  Abnova Taiwan Corp.

KLKB1 / Kininogen (cleaved) antibody

Western blot analysis of extracts from HeLa cells, using KLKB1 (heavy chain,Cleaved-Arg390) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

KLKB1 / Kininogen (cleaved) antibody

Western blot analysis of extracts from HeLa cells, using KLKB1 (heavy chain,Cleaved-Arg390) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

KLKB1 / Kininogen antibody

Human Liver; WB Suggested Anti-KLKB1 Antibody Titration: 2.5ug/ml. Positive Control: Human Liver; KLKB1 antibody - middle region (ARP45678_T100) in Human Liver cells using Western Blot Rabbit Aff - Purified Hu, Por WB
0.1 mg / €310.00
  AVIVA Systems Biology

KLKB1 / Kininogen (C-term) antibody

Rat Brain; WB Suggested Anti-Klkb1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Rat Brain; Klkb1 antibody - C-terminal region (ARP45679_P050) in Rat Brain cells using Western Blot Rabbit Aff - Purified Hu, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

KLKB1 - human gene knockout kit via CRISPR

KLKB1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

KLKB1 - human gene knockout kit via CRISPR

KLKB1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

KLKB1 - human gene knockout kit via CRISPR

KLKB1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

KLKB1 - human gene knockout kit via CRISPR

KLKB1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KLKB1 / Kininogen

  Recombinant protein of human kallikrein B, plasma (Fletcher factor) 1 (KLKB1)  
KLKB1 / Kininogen Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

KLKB1 / Kininogen

KLKB1 / Kininogen Human Purified > 95 % pure by SDS-PAGE. Plasma
50 µg / €230.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

KLKB1 overexpression lysate

KLKB1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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