Klotho antibody

Principal name

Klotho antibody

Alternative names for Klotho antibody

KL, Klotho, EC 3.2.1.31

SwissProt ID

O35082 (Mouse), Q8WP17 (Macfa), Q9UEF7 (Human), Q9UEF7-2, Q9Z2Y9 (Rat)

Gene ID

9365 (KL), 16591 (Kl)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Rabbit, Goat, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunohistochemistry (IHC), Immunofluorescence (IF)

Background of Klotho antibody

Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon,. The full length transmembrane form has a large extracellular domain composed of two homologous subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively, The predominant circulating form, which is derived from alternative RNA splicing, contains the KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho protein of about 128 kDa has been identified in the blood and cerebrospinal fluid. This circulating protein arises from the action of an as yet unidentified protease which cleaves transmembrane Klotho just above and/or within the plasma membrane. Klotho has been shown to play a key role in the signaling cascade of fibroblast growth factor-23 (FGF-23), a bone derived hormone that acts in the kidney to inhibit phosphate reabsorption and vitamin D biosynthesis. Klotho promotes FGF-23 signaling through binding to FGFRI (IIIc) which converts this canonical FGF receptor into a specific receptor for FGF-23. In the absence of Klotho the function of FGF-23 is literally abolished.

General readings

Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M. Suppression of ageing in mice by the hormone Klotho. Science. 2005 Sep 16;309(5742):1829-33. Epub 2005 Aug 25. PMID: 16123266

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Klotho antibody

(4ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Klotho antibody

Western blot analysis of KLOTHO in rat heart tissue lysate with KLOTHO antibody at (A) 1 and (B) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Klotho antibody

WB Suggested Anti-KL Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Thymus Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Klotho control peptide

Klotho
50 µg / €160.00
  Acris Antibodies GmbH

Klotho antibody

Western Blot (Unreduced) using Biotin conjugated Klotho antibody Cat.-No AP32851BT  Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

Klotho antibody

Western Blot (Unreduced) using Biotin conjugated Klotho antibody Cat.-No AP32851BT  Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Klotho antibody

Western Blot (Unreduced) using Klotho antibody Cat.-No AP32851PU Rabbit Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Klotho antibody

Western Blot (Unreduced) using Klotho antibody Cat.-No AP32851PU Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Acris Antibodies GmbH

Klotho antibody

Klotho Rat IgG2 4F54 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Klotho antibody

Klotho Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Klotho (N-term) antibody

Human Thymus; WB Suggested Anti-KL Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Thymus; KL antibody - N-terminal region (ARP36695_P050) in Human Thymus cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Klotho (Center) antibody

Human Kidney; Immunohistochemistry with Kidney tissue at an antibody concentration of 5ug/ml using anti-KL antibody (ARP41551_P050); KL antibody - middle region (ARP41551_P050) in Human Kidney cells using Immunohistochemistry Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Klotho antibody

Human PANC1; WB Suggested Anti-KL Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: PANC1 cell lysate; KL antibody - middle region (ARP41552_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Klotho antibody

Human Prostate; prostate; KL antibody - middle region (ARP41554_P050) in Human Prostate cells using Immunohistochemistry Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Klotho antibody

Klotho Rat IgG2a KM2076 Purified Hu, Ms, Rt IHC, WB
50 µg / €700.00
  Funakoshi Co., Ltd.

Klotho antibody

Klotho Rat IgG2b KM2119 Purified Hu, Ms WB
50 µg / €700.00
  Funakoshi Co., Ltd.

Klotho antibody

Immunohistochemistry-Paraffin: Klotho Antibody [NB100-2432] - Staining of paraffin embedded Human Breast. Goat IgG Aff - Purified Hu E, P
0.1 mg / €400.00
  Novus Biologicals Inc.

Klotho Control Peptide

Klotho
0.1 mg / €310.00
  Novus Biologicals Inc.

Klotho antibody

Western Blot: klotho Antibody [NBP1-55097] - This Anti-KL antibody was used in Western Blot of Fetal Thymus   tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Klotho antibody

Western Blot: Klotho Antibody [NBP1-76511] - Analysis of KLOTHO in rat heart tissue lysate with KLOTHO antibody at (A) 1 and (B) 2 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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