Klotho antibody

Principal name

Klotho antibody

Alternative names for Klotho antibody

KL, Klotho, EC 3.2.1.31

SwissProt ID

O35082 (Mouse), Q8WP17 (Macfa), Q9UEF7 (Human), Q9UEF7-2, Q9Z2Y9 (Rat)

Gene ID

9365 (KL), 16591 (Kl), 83504

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine), Ze (Zebrafish)

Available hosts

Goat, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Western blot / Immunoblot (WB), Immunohistochemistry (IHC), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Klotho antibody

Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon,. The full length transmembrane form has a large extracellular domain composed of two homologous subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively, The predominant circulating form, which is derived from alternative RNA splicing, contains the KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho protein of about 128 kDa has been identified in the blood and cerebrospinal fluid. This circulating protein arises from the action of an as yet unidentified protease which cleaves transmembrane Klotho just above and/or within the plasma membrane. Klotho has been shown to play a key role in the signaling cascade of fibroblast growth factor-23 (FGF-23), a bone derived hormone that acts in the kidney to inhibit phosphate reabsorption and vitamin D biosynthesis. Klotho promotes FGF-23 signaling through binding to FGFRI (IIIc) which converts this canonical FGF receptor into a specific receptor for FGF-23. In the absence of Klotho the function of FGF-23 is literally abolished.

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Klotho

  Purified recombinant protein of Human klotho (KL).  
Klotho Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
CHO cells
20 µg / €239.00
  OriGene Technologies, Inc.

Klotho

Klotho Human Purified > 98 % by SDS-PAGE and HPLC CHO cells
20 µg / €330.00
  Acris Antibodies GmbH

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