KPNA1 / Importin alpha-1 antibody

Principal name

KPNA1 / Importin alpha-1 antibody

Alternative names for KPNA1 / Importin alpha-1 antibody

Karyopherin alpha 1, SRP1, SRP1-beta, RCH2, IPOA5, NPI-1, Nucleoprotein interactor 1, RAG cohort protein 2

SwissProt ID

A2VE08 (Bovin), O14063 (Schpo), P52170 (Xenla), P52294 (Human), P83953 (Rat), Q02821 (Yeast), Q22560 (Caeel), Q5ZML1 (Chick), Q60960 (Mouse), Q96321 (Arath)

Gene ID

3836 (KPNA1), 16646 (Kpna1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Can (Canine), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KPNA1 / Importin alpha-1 antibody

Protein transfer into and out of the nucleus occurs through the nuclear pore complex (NPCs). Karyopherin, a cytosolic, heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex. SRP1 (nucleoprotein interactor 1, NPI 1) is the alpha subunit of
karyopherin, which acts as the receptor for the targeted protein’s nuclear localization signal (Moroianu J. Crit 1997). Both subunits of karyopherin are required for protein docking at the NPC; the alpha subunit binds the substrate and the beta subunit acts as an adaptor (Moroianu J, et al. 1995).
Two other proteins, p10 and the GTPase Ran, are also required for the translocation of docked proteins to the nucleus. The karyopherin dimer dissociates during import, a process mediated by RanGTP, which binds to karyopherin ß and promotes the release of both subunits from the docking site (Moroianu J. Crit 1997). The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC (Moroianu J. Crit 1997)

General readings

Cortes P, Ye ZS, Baltimore D. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7633-7. PMID: 8052633

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KPNA1 / Importin alpha-1 (N-term) antibody

  Goat Polyclonal Antibody against KPNA1  
TA302916 staining (1µg/ml) of HeLa lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

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