KPNA2 / Importin alpha-2 antibody

Principal name

KPNA2 / Importin alpha-2 antibody

Alternative names for KPNA2 / Importin alpha-2 antibody

Karyopherin alpha-2, SRP1-alpha, RAG cohort protein 1, RCH1

SwissProt ID

P52171 (Xenla), P52292 (Human), P52293 (Mouse)

Gene ID

3838 (KPNA2), 16647 (Kpna2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of KPNA2 / Importin alpha-2 antibody

Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Moroianu J., et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92:6532-6536Braem C.V., et al. (2002) J. Biol. Chem. 277:19673-19678

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KPNA2 / Importin alpha-2 antibody

  KPNA2 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using KPNA2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2 (C-term) antibody

  Goat Polyclonal Antibody against KPNA2  
TA302917 staining (0.1 ug/ml) of Hela lysate (RIPA buffer, 35 ug total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2 antibody

  Rabbit polyclonal antibody to karyopherin alpha 2 (karyopherin alpha 2 (RAG cohort 1, importin alpha 1))  
Sample(30 ug of whole cell lysate). A:HeLa S3. B:Hep G2. C:MOLT4. 10% SDS PAGE. TA308727 diluted at 1:500 Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2 (N-term) antibody

  Rabbit Polyclonal KPNA2 Antibody  
Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 antibody at (A) 1 and (B) 2 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2 antibody

  Rabbit Polyclonal Anti-KPNA2 Antibody  
WB Suggested Anti-KPNA2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2 (N-term) antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

KPNA2 / Importin alpha-2 antibody

KPNA2 / Importin alpha-2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

KPNA2 / Importin alpha-2 antibody

Western Blot analysis of KPNA2 expression in transfected 293T cell line (H00003838-T01) by KPNA2 MaxPab polyclonal antibody.

Lane 1: KPNA2 transfected lysate(58.19 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

KPNA2 / Importin alpha-2 antibody

KPNA2 / Importin alpha-2 Rat IgG2a 2G7 Hu WB
50 µl / €560.00
  Abnova Taiwan Corp.

KPNA2 / Importin alpha-2 antibody

KPNA2 polyclonal antibody ( Cat # PAB6558 ) staining ( top panel and green ) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker ( mid panel and red ) . Data kindly provided by Francisco Iborra, MRC Mol. Haematol. Unit, Oxford. Goat Hu E, ICC/IF, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KPNA2 / Importin alpha-2 antibody

Transfected 293T; WB Suggested Anti-KPNA2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Transfected 293T; KPNA2 antibody - middle region (ARP54673_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

Kpna2 - mouse gene knockout kit via CRISPR

Kpna2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kpna2 - mouse gene knockout kit via CRISPR

Kpna2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kpna2 - mouse gene knockout kit via CRISPR

Kpna2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kpna2 - mouse gene knockout kit via CRISPR

Kpna2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KPNA2 / Importin alpha-2

  Recombinant protein of human karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)  
KPNA2 / Importin alpha-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2

  Recombinant protein of human karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)  
KPNA2 / Importin alpha-2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2 (1-529, His-tag)

KPNA2 / Importin alpha-2 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

KPNA2 / Importin alpha-2 (1-529, His-tag)

KPNA2 / Importin alpha-2 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

KPNA2 / Importin alpha-2

KPNA2 / Importin alpha-2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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