KPNA2 / Importin alpha-2 antibody

Principal name

KPNA2 / Importin alpha-2 antibody

Alternative names for KPNA2 / Importin alpha-2 antibody

Karyopherin alpha-2, SRP1-alpha, RAG cohort protein 1, RCH1

SwissProt ID

P52171 (Xenla), P52292 (Human), P52293 (Mouse)

Gene ID

3838 (KPNA2), 16647 (Kpna2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of KPNA2 / Importin alpha-2 antibody

Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Moroianu J., et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92:6532-6536Braem C.V., et al. (2002) J. Biol. Chem. 277:19673-19678

4 Item(s)

per page

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KPNA2 / Importin alpha-2

  Recombinant protein of human karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)  
KPNA2 / Importin alpha-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2

  Recombinant protein of human karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)  
KPNA2 / Importin alpha-2 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

KPNA2 / Importin alpha-2 (1-529, His-tag)

KPNA2 / Importin alpha-2 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

KPNA2 / Importin alpha-2 (1-529, His-tag)

KPNA2 / Importin alpha-2 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

4 Item(s)

per page
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