KPNA4 / Importin alpha-4 antibody

Principal name

KPNA4 / Importin alpha-4 antibody

Alternative names for KPNA4 / Importin alpha-4 antibody

QIP1, Karyopherin subunit alpha-4, Importin alpha Q1

SwissProt ID

O00629 (Human), O35343 (Mouse)

Gene ID

3840 (KPNA4), 16649 (Kpna4)

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Prim (Primate), Rb (Rabbit), Rt (Rat), Xen (Xenopus), Ze (Zebrafish), Tr (Turkey), Bear, African clawed frog, GP (Guinea Pig)

Available hosts

Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KPNA4 / Importin alpha-4 antibody

KPNA4 (karyopherin alpha 4), also known as importin alpha 3, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers.

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.

General readings

Yeung,P.L., (2008) J. Cell. Biochem. 103 (2), 456-470

  1. Quick-Filters:
  2. Cited (1)
  3. Highly Validated (3)

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KPNA4 / Importin alpha-4 (C-term) antibody

  Goat Polyclonal Antibody against KPNA4 / IPOA3  
TA302525 staining (0.5µg/ml) of Human Testis lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 antibody

  Rabbit Polyclonal antibody to KPNA4 (karyopherin alpha 4 (importin alpha 3))  
KPNA4 antibody [C3], C-term detects KPNA4 protein by Western blot analysis. A. 30 ug Rat2 whole cell lysate/extract. 7.5 % SDS-PAGE. KPNA4 antibody [C3], C-term (TA308726) dilution: 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 (N-term) antibody

  Rabbit Polyclonal KPNA4 Antibody  
Western blot analysis of KPNA1 in Hela cell lysate with KPNA1 antibody at 1ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 antibody

  Rabbit Polyclonal Anti-KPNA4 Antibody  
KPNA4 antibody - N-terminal region validated by WB using Neuro 2A Cells at 1: 500. Rabbit IgG Purified Bov, Can, Eq, GP, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 antibody

  Rabbit anti-KPNA4 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using KPNA4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 (509-521) antibody

Small intestine: Fromalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Platypus, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

KPNA4 / Importin alpha-4 (N-term) antibody

The anti-Importin alpha-4 (AP11806PU-N) is used in Western blot to detect Importin alpha-4 in Hela (left), mouse brain (middle), and HepG2 (right)cell line/tissue lysates. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KPNA4 / Importin alpha-4 (N-term) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Kpna4 - mouse gene knockout kit via CRISPR

Kpna4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Kpna4 - mouse gene knockout kit via CRISPR

Kpna4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Kpna4 - mouse gene knockout kit via CRISPR

Kpna4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KPNA4 / Importin alpha-4

  Recombinant protein of human karyopherin alpha 4 (importin alpha 3) (KPNA4)  
KPNA4 / Importin alpha-4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

KPNA4 overexpression lysate

KPNA4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KPNA4 (mGFP-tagged) - Human karyopherin alpha 4 (importin alpha 3) (KPNA4), 200 uL, >10^7 TU/mL

Lenti ORF particles, KPNA4 (mGFP-tagged) - Human karyopherin alpha 4 (importin alpha 3) (KPNA4), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KPNA4 (Myc-DDK tagged) - Human karyopherin alpha 4 (importin alpha 3) (KPNA4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, KPNA4 (Myc-DDK tagged) - Human karyopherin alpha 4 (importin alpha 3) (KPNA4) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Kpna4 (GFP-tagged) - Mouse karyopherin (importin) alpha 4 (Kpna4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kpna4 (GFP-tagged) - Mouse karyopherin (importin) alpha 4 (Kpna4), 200 uL, >10^7 TU/mL  
200 µl / €1,150.00
  OriGene Technologies, Inc.

Lenti ORF particles, Kpna4 (Myc-DDK-tagged) - Mouse karyopherin (importin) alpha 4 (Kpna4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Kpna4 (Myc-DDK-tagged) - Mouse karyopherin (importin) alpha 4 (Kpna4), 200 uL, >10^7 TU/mL  
200 µl / €1,030.00
  OriGene Technologies, Inc.

17 Item(s)

per page
  • LinkedIn