KPNA4 / Importin alpha-4 antibody

Principal name

KPNA4 / Importin alpha-4 antibody

Alternative names for KPNA4 / Importin alpha-4 antibody

QIP1, Karyopherin subunit alpha-4, Importin alpha Q1

SwissProt ID

O00629 (Human), O35343 (Mouse)

Gene ID

3840 (KPNA4)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), African clawed frog, Hst (Hamster), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KPNA4 / Importin alpha-4 antibody

KPNA4 (karyopherin alpha 4), also known as importin alpha 3, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers.

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.

General readings

Seki T et al. Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL. Biochem Biophys Res Commun 234:48-53 (1997). PubMed PMID: 9168958

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KPNA4 / Importin alpha-4 (C-term) antibody

TA302525 staining (0.5µg/ml) of Human Testis lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 antibody

KPNA4 antibody [C3], C-term detects KPNA4 protein by Western blot analysis. A. 30 ug Rat2 whole cell lysate/extract. 7.5 % SDS-PAGE. KPNA4 antibody [C3], C-term (TA308726) dilution: 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 (N-term) antibody

Western blot analysis of KPNA1 in Hela cell lysate with KPNA1 antibody at 1ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 antibody

KPNA4 antibody - N-terminal region validated by WB using Neuro 2A Cells at 1: 500. Rabbit IgG Purified Bov, Can, Eq, GP, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 antibody

Human Hela; Host: Rabbit . Target Name: KPNA4 . Sample Tissue: Hela . Antibody Dilution: 1.0ug/ml. KPNA4 is supported by BioGPS gene expression data to be expressed in HeLa.; KPNA4 antibody - N-terminal region (ARP54676_P050) in Human Hela cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

KPNA4 / Importin alpha-4 antibody

Western blot analysis of extracts of various cell lines, using KPNA4 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4 (509-521) antibody

Small intestine: Fromalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Platypus, Prim, Rb, Rt, Tr, Xen, Ze E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

KPNA4 / Importin alpha-4 (N-term) antibody

The anti-Importin alpha-4 (AP11806PU-N) is used in Western blot to detect Importin alpha-4 in Hela (left), mouse brain (middle), and HepG2 (right)cell line/tissue lysates. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

KPNA4 / Importin alpha-4 control peptide

KPNA4 / Importin alpha-4
50 µg / €160.00
  Acris Antibodies GmbH

KPNA4 / Importin alpha-4 (N-term) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

KPNA4 / Importin alpha-4 antibody

The KPNA4 polyclonal antibody ( Cat # PAB3804 ) is used in Western blot to detect KPNA4 in Hela ( left ) , mouse brain ( middle ) , and HepG2 ( right ) cell and tissue lysates. Rabbit Hu, Ms E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

KPNA4 / Importin alpha-4 antibody

KPNA4 polyclonal antibody ( Cat # PAB6561 ) ( 3 µg/ml ) staining of paraffin embedded human testis. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Hu, Ms E, P, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

KPNA4 / Importin alpha-4 antibody

KPNA4 / Importin alpha-4 Rat IgG2a 3D10 Purified Bov, Can, Hst, Hu, Ms, Rt ELISA, WB
0.1 mg / €510.00
  Funakoshi Co., Ltd.

KPNA4 / Importin alpha-4 antibody

Immunohistochemistry: KPNA4 Antibody [NB100-1374] - NB100-1374 (3ug/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. Goat IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

KPNA4 / Importin alpha-4 antibody

Immunohistochemistry-Paraffin: KPNA4 Antibody [NB100-81651] - FFPE section of human pancreatic islet cell tumor.  Affinity purified rabbit anti-KPNA4 used at a dilution of 1:250. DAB staining using Immunohistochemistry Accessory Kit Rabbit IgG Aff - Purified Hu IP, P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

KPNA4 / Importin alpha-4 antibody

Immunofluorescence: KPNA4 Antibody [NBP1-31260] - Immunofluorescence analysis of HeLa, using KPNA4 antibody at 1:200 dilution. Rabbit IgG Hu ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KPNA4 / Importin alpha-4

KPNA4 / Importin alpha-4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

KPNA4 / Importin alpha-4

KPNA4 / Importin alpha-4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

KPNA4 / Importin alpha-4

KPNA4 / Importin alpha-4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

KPNA4 overexpression lysate

KPNA4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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