KRIT1 / CCM1 antibody

Principal name

KRIT1 / CCM1 antibody

Alternative names for KRIT1 / CCM1 antibody

Krev interaction trapped 1

SwissProt ID

O00522 (Human), Q6S5J6 (Mouse), Q6TNJ1 (Bovin)

Gene ID

889 (KRIT1), 79264 (Krit1)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of KRIT1 / CCM1 antibody

Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM-1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However, cellular functions of CCM-1 during the early steps of the CCM pathogenesis remain unknown. It was shown that CCM-1 represents an antiangiogenic protein to keep the human endothelium quiescent. CCM-1 inhibits endothelial proliferation, apoptosis, migration, lumen formation, and sprouting angiogenesis in primary human endothelial cells. CCM-1 strongly induces DLL4-NOTCH signaling, which promotes AKT phosphorylation but reduces phosphorylation of the mitogen-activated protein kinase ERK. Consistently, blocking of NOTCH activity alleviates CCM-1 effects. ERK phosphorylation is increased in human CCM lesions. Transplantation of CCM-1-silenced human endothelial cells into SCID mice recapitulates hallmarks of the CCM pathology and serves as a unique CCM model system.
The CCM-1 is fused to a N-terminal His-tag (6x His).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KRIT1 / CCM1 antibody

Immunofluorescence staining of Human foreskin (Cryo-section of unfixed tissue) with anti-CCM1 Antibody Cat.-No AP26021PU-L (red, dilution: 1/50). Costaining of endothelial cells with anti-CD31 (green). Note specific staining in the wall of a subset of vessel. Nuclei counter-stained with Dapi (blue). Specimen provided by Prof. Dr. J. Wilting and Dr. K. Buttler, Goettingen. Rabbit IgG Purified Hu ICC/IF, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

KRIT1 / CCM1 antibody

Immunofluorescence staining of Human foreskin (Cryo-section of unfixed tissue) with anti-CCM1 Antibody Cat.-No AP26021PU-L (red, dilution: 1/50). Costaining of endothelial cells with anti-CD31 (green). Note specific staining in the wall of a subset of vessel. Nuclei counter-stained with Dapi (blue). Specimen provided by Prof. Dr. J. Wilting and Dr. K. Buttler, Goettingen. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

KRIT1 / CCM1 antibody

KRIT1 / CCM1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

KRIT1 / CCM1 antibody

Western Blot analysis of KRIT1 expression in transfected 293T cell line by KRIT1 monoclonal antibody (M01), clone 2C7.

Lane 1: KRIT1 transfected lysate(84.3 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 2C7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KRIT1 / CCM1 antibody

KRIT1 / CCM1 Mouse IgG1 1D8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

Krit1 - mouse gene knockout kit via CRISPR

Krit1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Krit1 - mouse gene knockout kit via CRISPR

Krit1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Krit1 - mouse gene knockout kit via CRISPR

Krit1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Krit1 - mouse gene knockout kit via CRISPR

Krit1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KRIT1 / CCM1 (His-tag)

SDS-PAGE analysis of recombinant human CCM1 “FERM domain”. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue. Human Purified > 90 % by SDS-PAGE and silver stain E. coli
20 µg / €200.00
  Acris Antibodies GmbH

KRIT1 / CCM1

KRIT1 / CCM1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KRIT1 / CCM1

KRIT1 / CCM1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (mGFP-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, KRIT1 (mGFP-tagged) - Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (mGFP-tagged) - Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €1,550.00
  OriGene Technologies, Inc.

Lenti ORF particles, KRIT1 (Myc-DDK-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (Myc-DDK-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, KRIT1 (Myc-DDK-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (Myc-DDK-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, KRIT1 (Myc-DDK-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, KRIT1 (Myc-DDK-tagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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