KRIT1 / CCM1 antibody

Principal name

KRIT1 / CCM1 antibody

Alternative names for KRIT1 / CCM1 antibody

Krev interaction trapped 1

SwissProt ID

O00522 (Human), Q6S5J6 (Mouse), Q6TNJ1 (Bovin)

Gene ID

889 (KRIT1), 4889760 (BMA10247_A1385)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P)

Background of KRIT1 / CCM1 antibody

Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits EKR1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin D1 levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

KRIT1 / CCM1 antibody

Immunofluorescence staining of Human foreskin (Cryo-section of unfixed tissue) with anti-CCM1 Antibody Cat.-No AP26021PU-L (red, dilution: 1/50). Costaining of endothelial cells with anti-CD31 (green). Note specific staining in the wall of a subset of vessel. Nuclei counter-stained with Dapi (blue). Specimen provided by Prof. Dr. J. Wilting and Dr. K. Buttler, Goettingen. Rabbit IgG Purified Hu ICC/IF, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

KRIT1 / CCM1 antibody

Immunofluorescence staining of Human foreskin (Cryo-section of unfixed tissue) with anti-CCM1 Antibody Cat.-No AP26021PU-L (red, dilution: 1/50). Costaining of endothelial cells with anti-CD31 (green). Note specific staining in the wall of a subset of vessel. Nuclei counter-stained with Dapi (blue). Specimen provided by Prof. Dr. J. Wilting and Dr. K. Buttler, Goettingen. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

KRIT1 / CCM1 antibody

KRIT1 / CCM1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

KRIT1 / CCM1 antibody

Western Blot analysis of KRIT1 expression in transfected 293T cell line by KRIT1 monoclonal antibody (M01), clone 2C7.

Lane 1: KRIT1 transfected lysate(84.3 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 2C7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

KRIT1 / CCM1 antibody

KRIT1 / CCM1 Mouse IgG1 1D8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

KRIT1 / CCM1 (His-tag)

SDS-PAGE analysis of recombinant human CCM1 “FERM domain”. Sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue. Human Purified > 90 % by SDS-PAGE and silver stain E. coli
20 µg / €200.00
  Acris Antibodies GmbH

KRIT1 / CCM1

KRIT1 / CCM1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

KRIT1 / CCM1

KRIT1 / CCM1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

8 Item(s)

per page
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