Alternative names for L1TD1 antibody
ECAT11, ES cell-associated protein 11, LINE-1 type transposase domain-containing protein 1
Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)
Background of L1TD1 antibody
L1TD1 Antibody: L1TD1 (ECAT11) is a member of the family of Embryonic Stem Cell Associated Transcripts (ECAT) that play an important role in stem cell biology. ECAT4 (nog) is a master regulator for the maintence of mESC and hESC. ECAT5 was identified to be Embryonic stem cell expressed Ras (ERas), a Ras-like oncogene that is important in regulating mESC proliferation. ECAT9 (GDF3) is an important factor that helps maintain mESC pluripotency by inhibiting bone morphogenetic protein (BMP) sigling. L1TD1 is highly enriched in undifferentiated hESC and L1TD1 is a target gene of nog.
Iwabuchi KA, Yamakawa T, Sato Y, et al. ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency. PLoS One. 2011; 6:e20461.
Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003; 113:631-42
Takahashi K, Mitsui K, Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature 2003; 423:541-5
Wong RC, Ibrahim A, Fong H, et al. L1TD1 is a marker for undifferentiated human embryonic stem cells. PLoS One 2011;6:e19355.