Lamin-A/C (LMNA) antibody

Principal name

Lamin-A/C (LMNA) antibody

Alternative names for Lamin-A/C (LMNA) antibody

LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32

SwissProt ID

P02545 (Human), P11048 (Xenla), P13648 (Chick), P48678 (Mouse), P48679 (Rat), Q3ZD69 (Pig)

Gene ID

4000 (LMNA)

Available reactivities

Bov (Bovine), Hu (Human), Por (Porcine), Ms (Mouse), Rt (Rat), Can (Canine), Hst (Hamster), Sh (Sheep), Fi (Fish), Xen (Xenopus), Duck, Ze (Zebrafish), Ce (C. elegans), Mky (Monkey), Chk (Chicken)

Available hosts

Mouse, Rabbit, Goat, Chicken

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Lamin-A/C (LMNA) antibody

The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm. The Lamins function as skeletal components tightly associated with the inner nuclear membrane. Origilly the proteins of the nuclear cytoskeleton were med Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene, while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes a C-termil segment of 98 amino acids missing from Lamin C, while Lamin C has a unique C-termil 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kise 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kise increases during cell division and is responsible for the breakdown of the nuclear lami. Mutations in the LM gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some Laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lami binding proteins. A truncated version of Lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging.

General readings

1. Kong L  et al. Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. Carcinogenesis 33:751-9 (2012).PubMed: 22301279
2. Hoftman AD  et al. MAGE-B2 autoantibody: a new biomarker for pediatric systemic lupus erythematosus. J Rheumatol 35:2430-8 (2008). WB ; Human .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Lamin (pan) antibody

Table 1. Antigen Recognized in Tested Species. Mouse IgG1 X67, X167, X223 Supernatant Bov, Fi, Hu, Ms, Rt, Xen C, ICC/IF, WB
5 ml / €230.00
  Acris Antibodies GmbH

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 X167 Purified Bov, Fi, Hu, Xen ICC/IF, WB
50 µg / €300.00
  Acris Antibodies GmbH

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 X167 Supernatant Bov, Fi, Hu, Xen ICC/IF, WB
5 ml / €230.00
  Acris Antibodies GmbH

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 1A9E3 Hu E
0.2 mg / €820.00
  Abnova Taiwan Corp.

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 2A61G1 Hu E
0.2 mg / €820.00
  Abnova Taiwan Corp.

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 4D3B9 Hu E
0.2 mg / €820.00
  Abnova Taiwan Corp.

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 2B21B7 Ms E
0.2 mg / €730.00
  Abnova Taiwan Corp.

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 4B111E5 Ms E
0.2 mg / €730.00
  Abnova Taiwan Corp.

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 3C92D7 Ms E
0.2 mg / €730.00
  Abnova Taiwan Corp.

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 4D22C11 Ms E
0.2 mg / €730.00
  Abnova Taiwan Corp.

Lamin-A/C (LMNA) antibody

Immunostaining of human epidermis using Lamin A antibody BM4500 Mouse IgG3 133A2 Purified Bov, Can, Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Lamin-A/C (LMNA) antibody

Lamin A/C antibody detects LMNA protein by Western blot analysis. A. 30 ug NIH-3T3 whole cell lysate/extract. 7.5 % SDS-PAGE. Lamin A/C antibody (TA308920) dilution: 1:1000 Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

Immunohistochemical analysis of paraffin-embedded human striated muscle tissues using LMNA mouse mAb with DAB staining. Mouse IgG1 4E7 Ascites Hu, Ms, Rt E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Lamin-A/C (LMNA) antibody

Immunofluorescence of purified MaxPab antibody to LMNA on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Lamin-A/C (LMNA) antibody

Western Blot: Lamin A + C R482W Antibody (5H8-B4) - Western blot analysis of Lamin A + C R482W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R482W and 3) R453W. Mouse IgG1 5H8-B4 Purified Hu E, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Western blot analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W. Mouse IgG1 12A-2F5 Purified Hu E, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

Western blot analysis of Lamin A/C expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

Western blot analysis of extracts from HeLa cells, treated with etoposide (25.M, 1hour), using Lamin A (cleaved-Asp230) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

Western blot analysis of extracts from NIH/3T3cells, treated with Etoposide (25.M, 60mins), using Lamin A (Cleaved-Asp230) Antibody (#TA326151).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

Western blot analysis of extracts of various cell lines, using LMNA antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

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