Lamin-A/C (LMNA) antibody

Principal name

Lamin-A/C (LMNA) antibody

Alternative names for Lamin-A/C (LMNA) antibody

LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32

SwissProt ID

P02545 (Human), P11048 (Xenla), P13648 (Chick), P48678 (Mouse), P48679 (Rat), Q3ZD69 (Pig)

Gene ID

4000 (LMNA), 16905 (Lmna), 60374

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Hst (Hamster), Sh (Sheep), Fi (Fish), Xen (Xenopus), Bt (Bat), Eq (Equine), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Bear, Ze (Zebrafish), Chk (Chicken), Mam (Mammalia)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of Lamin-A/C (LMNA) antibody

The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm. The Lamins function as skeletal components tightly associated with the inner nuclear membrane. Origilly the proteins of the nuclear cytoskeleton were med Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene, while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes a C-termil segment of 98 amino acids missing from Lamin C, while Lamin C has a unique C-termil 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kise 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kise increases during cell division and is responsible for the breakdown of the nuclear lami. Mutations in the LM gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some Laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lami binding proteins. A truncated version of Lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging.

General readings

1. Kong L  et al. Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. Carcinogenesis 33:751-9 (2012).PubMed: 22301279
2. Hoftman AD  et al. MAGE-B2 autoantibody: a new biomarker for pediatric systemic lupus erythematosus. J Rheumatol 35:2430-8 (2008). WB ; Human .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Lamin (pan) antibody

Table 1. Antigen Recognized in Tested Species. Mouse IgG1 X67, X167, X223 Supernatant Bov, Fi, Hu, Ms, Rt, Xen C, ICC/IF, WB
5 ml / €240.00
  Acris Antibodies GmbH

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 X167 Purified Bov, Fi, Hu, Xen ICC/IF, WB
50 µg / €310.00
  Acris Antibodies GmbH

Lamin (pan) antibody

Lamin (pan) Mouse IgG1 X167 Supernatant Bov, Fi, Hu, Xen ICC/IF, WB
5 ml / €240.00
  Acris Antibodies GmbH

Lamin-A/C (LMNA) antibody

Immunostaining of human epidermis using Lamin A antibody BM4500 Mouse IgG3 133A2 Purified Bov, Can, Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Lamin-A/C (LMNA) antibody

  Rabbit Polyclonal antibody to Lamin A/C (lamin A/C)  
Lamin A/C antibody detects LMNA protein by Western blot analysis. A. 30 ug NIH-3T3 whole cell lysate/extract. 7.5 % SDS-PAGE. Lamin A/C antibody (TA308920) dilution: 1:1000 Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

Immunohistochemical analysis of paraffin-embedded human striated muscle tissues using LMNA mouse mAb with DAB staining. Mouse IgG1 4E7 Ascites Hu, Ms, Rt E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Lamin-A/C (LMNA) antibody

  Mouse Monoclonal Lamin A + C R482W Antibody (5H8-B4)  
Western Blot: Lamin A + C R482W Antibody (5H8-B4) - Western blot analysis of Lamin A + C R482W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R482W and 3) R453W. Mouse IgG1 5H8-B4 Purified Hu E, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Mouse Monoclonal Lamin A + C R453W Antibody (12A-2F5)  
Western Blot: Lamin A + C R453W Antibody (12A-2F5) - Western blot analysis of Lamin A + C R453W in HeLa cells transfected with Flag-tagged Lamin A 1) wild type, 2) R453W and 3) R482W. Mouse IgG1 12A-2F5 Purified Hu E, ICC/IF, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Rabbit Polyclonal Lamin A/C Antibody  
Western blot analysis of Lamin A/C expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Rabbit Polyclonal Lamin A/C (Ser392) Antibody (Phospho-specific)  
Western blot analysis of Lamin A/C phosphorylation expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Rabbit polyclonal Lamin A (Cleaved-Asp230) antibody  
Western blot analysis of extracts from HeLa cells, treated with etoposide (25.M, 1hour), using Lamin A (cleaved-Asp230) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Rabbit polyclonal Lamin A (Cleaved-Asp230) antibody  
Western blot analysis of extracts from NIH/3T3cells, treated with Etoposide (25.M, 60mins), using Lamin A (Cleaved-Asp230) Antibody (#TA326151).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  LMNA Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using LMNA antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Rabbit Polyclonal anti-Lamin A Antibody  
Hela cell nuclear extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal anti-lamin A. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Poly6135 Purified Hu, Ms ICC/IF, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Mouse Monoclonal Lamin A C Antibody (4C4)  
Western Blot: Lamin A + C Antibody (4C4) [TA337104] - Stripe blots of crude HeLa cell extract. Note two strong clean bands at 74 kDa and 64 kDa, corresponding to Lamin A and C, in lane 6. Lane 5 was stained with an antibody to Enolase 1. Lanes 3 and 4 wer Mouse IgG1 4C4 Purified Bov, Hu, Ms, Por, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Chicken Polyclonal Lamin A C Antibody  
Western Blot: Lamin A + C Antibody [TA337105] - Stripe blot of crude HeLa cell extract. Note two strong clean bands at 74kDa and 65kDa, corresponding to Lamins A and C. Chicken Purified Bov, Hu, Ms, Por, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Rabbit Polyclonal Lamin A C Antibody  
Western Blot: Lamin A + C Antibody [TA337106] - Stripe blot of crude HeLa cell extract. Note two strong and clean bands at 74kDa and 65kDa, corresponding to Lamin A and C. Rabbit Purified Bov, Hu, Ms, Por, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Mouse Monoclonal Lamin A Antibody  
Western blot detection of Lamin A in K562,C6,3T3 and Hela cell lysates using Lamin A mouse mAb (1:1000 diluted).Predicted band size:74KDa.Observed band size:74KDa. Mouse IgG2a 3D6-F4-B7 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Mouse Monoclonal Lamin A/C Antibody  
Western blot detection of Lamin A/C in MCF7,A549 and Hela cell lysates using Lamin A/C mouse mAb (1:1000 diluted).Predicted band size:74,63KDa.Observed band size:74,63KDa. Mouse IgG1 5D12-C6-E9 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lamin-A/C (LMNA) antibody

  Rabbit Polyclonal Anti-LMNA Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-3: A431 cells, A375 cells, hela cells, Primary antibody: (LMNA Antibody) at dilution 1/520, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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