Laminin alpha 4 antibody

Principal name

Laminin alpha 4 antibody

Alternative names for Laminin alpha 4 antibody

LAMA4, Laminin subunit alpha-4

SwissProt ID

P97927 (Mouse), Q16363 (Human)

Gene ID

3910 (LAMA4), 16775 (Lama4)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of Laminin alpha 4 antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, sigling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are desigted by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-termil G domain which distinguishes all alpha chains from the beta and gamma chains. The R alysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of altertive polyA-sigl has been described in literature. Altertive splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011].

General readings

Wondimu Z, Geberhiwot T, Ingerpuu S, Juronen E, Xie X, Lindbom L, Doi M, Kortesmaa J, Thyboll J, Tryggvason K, Fadeel B, Patarroyo M. (2004) An endothelial laminin isoform, laminin-8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis. Blood, 104(6):1859-66. PMID: 15172971.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Laminin alpha 4 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LAMA4 mouse monoclonal antibody. (TA805721; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG1 OTI5G8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Laminin alpha 4 antibody

Western blot analysis of extracts from COLO cells and 293 cells, using LAMA4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Laminin alpha 4 antibody

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (LAMA4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Laminin alpha 4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LAMA4 (RC226434, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LAMA4. Mouse IgG2a OTI4A8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Laminin alpha 4 antibody

Reactivity of laminin alpha4 chain specific monoclonal antibody 3H2 on human platelet lysate by Western blotting (reducing, R and nonreducing, NR conditions). Mouse IgG1 3H2 Purified Hu C, E, IP, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Laminin alpha 4 antibody

Reactivity of laminin alpha4 chain specific monoclonal antibody 6C3 on human platelet lysate by Western blotting (reducing, R and nonreducing, NR conditions). Mouse IgG1 6C3 Purified Hu E, IP, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Laminin alpha 4 antibody

Reactivity of laminin alpha4 chain specific monoclonal antibody 9B8 on human platelet lysate by Western blot (reducing, R and nonreducing, NR conditions). Mouse IgG1 9B2 Purified Hu E, IP, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Laminin alpha 4 antibody

Immunohistochemistry (IHC) analyzes of Laminin alpha-4 antibody (Cat.-No.: AP20549PU-N) in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Laminin alpha 4 antibody

Western Blot analysis of LAMA4 expression in transfected 293T cell line (H00003910-T02) by LAMA4 MaxPab polyclonal antibody.

Lane 1: LAMA4 transfected lysate(13.2 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Laminin alpha 4 antibody

Western Blot analysis of LAMA4 expression in transfected 293T cell line (H00003910-T02) by LAMA4 MaxPab polyclonal antibody.

Lane 1: LAMA4 transfected lysate(13.2 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Laminin alpha 4 antibody

Laminin alpha 4 Mouse Hu WB
50 µl / €370.00
  Abnova Taiwan Corp.

Laminin alpha 4 antibody

Laminin alpha 4 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

Laminin alpha 4 antibody

Western Blot analysis of LAMA4 expression in transfected 293T cell line (H00003910-T03) by LAMA4 MaxPab polyclonal antibody.

Lane 1: LAMA4 transfected lysate(12.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Laminin alpha 4 antibody

Laminin alpha 4 Mouse IgG1 652C4 Hu C
0.1 ml / €730.00
  Abnova Taiwan Corp.

Laminin alpha 4 antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using LAMA4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

Laminin alpha 4 antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using LAMA4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

LAMA4 - human gene knockout kit via CRISPR

LAMA4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

LAMA4 - human gene knockout kit via CRISPR

LAMA4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

LAMA4 - human gene knockout kit via CRISPR

LAMA4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

LAMA4 - human gene knockout kit via CRISPR

LAMA4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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