Laminin antibody

Principal name

Laminin antibody

Available reactivities

Ms (Mouse), Hu (Human), Por (Porcine), Rt (Rat), Bov (Bovine), Mam (Mammalia), Rb (Rabbit), Chk (Chicken), Duck, Hst (Hamster), Fe (Feline), Re (Reptiles)

Available hosts

Rabbit, Mouse, Rat, Chicken

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Functional assay (FN), Immunoprecipitation (IP)

Background of Laminin antibody

Laminin, the most abundant structural and biologically active component in basement membranes, is a complex extracellular glycoprotein with an approximate molecular weight of 900 kD. It plays an important role in many aspects of the cell biology. Laminin is composed of one A chain (400 kD) one B1 chain (215 kD) and one B2 chain (205 kD) all held together by disulfide bonds. The molecule has a cross-like form with globular units near the ends of each chain, the sites where it is bound to Collagen IV, heparan sulfate, proteoglycan as well as to the surface of epithelial cells. Laminins from various species have common antigenic determinants. Laminin is only found in significant quantities in basement membranes, the thin extracellular matrices that surround epithelial tissue, nerve, fat cells and smooth, striated and cardiac muscle. It has been found to modulate cell differentiation, cell shaping and also cell movement because it appears to be an important cell substrate-adhesion protein. Variations in the expression of this protein have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. The greatest interest in laminin has been provoked by the discovery of its ability to promote neurite regeneration. Quantitation of laminin is beneficial by allowing for a method of non-invasive testing. For example, in fibrosis, a serious and frequent complication of chronic active liver disease characterized by excessive deposition of various normal components of connective tissue in liver, the concentration of laminin in serum is positively related to the severity of the fibrotic liver disease being significantly higher in cirrhosis than in mere fibrosis.

General readings

General / background references:Autio-Harmainen H et al. Synthesis of laminin and type IV collagen by trophoblastic cells and fibroblastic stromal cells in the early human placenta. Lab Invest 64:483-91 (1991). PubMed PMID: 2016854
Engvall E et al. Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits. Cell Regul 1:731-40 (1990). PubMed PMID: 2099832
Kleinman HK et al. Laminin receptors for neurite formation. Proc Natl Acad Sci U S A 85:1282-6 (1988). PubMed PMID: 2963341

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Laminin antibody

Laminin Mouse IgG1 LAM-26 Purified Fe, Hu, Por IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Laminin antibody

IHC Image for AP22651PU-N
Human Testis (formalin-fixed, paraffin-embedded) stained with Laminin antibody AP22651PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody LS-D1, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu E, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Laminin antibody

Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Rt P
0.1 ml / €470.00
  Acris Antibodies GmbH

Laminin antibody

Immunofluorescence staining of Frozen Sections from Human colon (methanol fixed) using BM6046P, showing the localization of laminin in the connective tissue and in basement membranes surrounding the epithelial crypts. Rat IgG2a A5 Purified Hu, Ms, Por C, ICC/IF
0.1 mg / €320.00
  Acris Antibodies GmbH

Laminin antibody

Laminin Rabbit Serum Bov, Hu, Mam, Ms, Por, Rb, Rt C, P, WB
0.25 ml / €360.00
  Acris Antibodies GmbH

Laminin antibody

Laminin Rabbit Purified Ms C, E, ICC/IF, P, R
0.5 ml / €680.00
  Acris Antibodies GmbH

Laminin P1 Fragment antibody

Laminin Rabbit Purified Hu C, E, ICC/IF, P, R
0.5 ml / €680.00
  Acris Antibodies GmbH

Laminin (alpha chains) antibody

Laminin Mouse IgG2a 4C7 Supernatant Hu C, P
1 ml / €600.00
  Acris Antibodies GmbH

Laminin (alpha chains) antibody

Laminin Mouse IgG2a 4C7 Supernatant Hu C, P
0.5 ml / €400.00
  Acris Antibodies GmbH

Laminin antibody

Laminin Rabbit Biotin Hu C, E, IP, P, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Laminin (alpha + beta chains) antibody

Staining of Formalin Fixed, Paraffin Embedded Human kidney with Laminin Antibody Cat.-No SP1091 Rabbit Serum Chk, Duck, Hu, Rb C, E, P
0.25 ml / €440.00
  Acris Antibodies GmbH

Laminin (alpha + beta chains) antibody

Staining of Formalin Fixed, Paraffin Embedded Human kidney with Laminin Antibody Cat.-No SP1091 Rabbit IgG Serum Hu C, E, P
50 µl / €240.00
  Acris Antibodies GmbH

Laminin antibody

Laminin Mouse IgG1 MEC5 Hu, Ms, Rt
1 ml / €730.00
  Abnova Taiwan Corp.

Laminin antibody

Laminin Rabbit IgG Hu E, IP, P, WB
0.1 mg / €560.00
  Abnova Taiwan Corp.

Laminin antibody

Laminin Rabbit Ig Hu, Ms P
1 ml / €560.00
  Abnova Taiwan Corp.

Laminin antibody

Laminin Rabbit IgG Hu E, ICC/IF, P, R
0.5 ml / €820.00
  Abnova Taiwan Corp.

Laminin antibody

Laminin Rabbit IgG Ms E, ICC/IF, P, R
50 µl / €470.00
  Abnova Taiwan Corp.

Laminin antibody

Laminin Mouse 4C7 Hu P
0.5 ml / €400.00
  Novus Biologicals Inc.

Laminin antibody

Laminin Rabbit Purified Hu, Ms, Rt C, FN, ICC/IF, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

Laminin antibody

Normal rabbit aorta, Lowicryl K4M thin section, stained with Monoclonal Anti-Chondroitin Sulfate, clone no. CS-56 (Cat. No. NB120-11570) and Goat Anti-Mouse IgM (ì-chain specific) 10 nm gold. Counterstain was uranyl acetate and Reynold's lead citrate. Magnification 44,600x. (el=Elastin, col=Collagen).  From Z. Gallis, McGill University, Montreal. Mouse IgG1 LAM-89 Ascites Fe, Hu, Por P
0.1 ml / €340.00
  Novus Biologicals Inc.

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