Laminin beta-2 antibody

Principal name

Laminin beta-2 antibody

Alternative names for Laminin beta-2 antibody

S-laminin, Laminin B1s chain, LAMB2, LAMS, Laminin-11 subunit beta, Laminin-14 subunit beta, Laminin-15 subunit beta, Laminin-3 subunit beta, Laminin-4 subunit beta, Laminin-7 subunit beta, Laminin-9 subunit beta

SwissProt ID

P15800 (Rat), P55268 (Human), Q61292 (Mouse)

Gene ID

3913 (LAMB2), 307582, 25473 (Lamb2)

Available reactivities

Bov (Bovine), GP (Guinea Pig), Hu (Human), Por (Porcine), Rb (Rabbit), Rt (Rat), Chk (Chicken), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C)

Background of Laminin beta-2 antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, sigling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are desigted by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was ictivated by homologous recombition, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Altertive splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript t

General readings

General / background references:Zwi LJ et al. Visualization of blood vessels without prior perfusion. Microvasc Res 58:79-82 (1999). PubMed PMID: 10388606
Burgi-Saville ME et al. Expression patterns of extracellular matrix components in native and cultured normal human thyroid tissue and in human toxic adenoma tissue. Thyroid 7:347-56 (1997). PubMed PMID: 9226202
Maier A & Mayne R Basal lamina development in chicken muscle spindles. Dev Dyn 202:284-93 (1995). PubMed PMID: 7780177
Green TL et al. Synthesis and assembly of the synaptic cleft protein S-laminin by cultured cells. J Biol Chem 267:2014-22 (1992). PubMed PMID: 1730732
Sanes JR et al. Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere. J Cell Biol 111:1685-99 (1990). PubMed PMID: 2211832
Hunter DD et al. A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction. Nature 338:229-34 (1989). PubMed PMID: 2922051
Sanes JR et al. Cold Spring Harbor Symposia on Quantitative Biology XLVIII 667-678 (1983).

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Laminin beta-2 antibody

  Rabbit polyclonal anti-LAMB2 antibody  
Western blot analysis of extracts from RAW264.7 cells, using LAMB2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

Laminin beta-2 antibody

  LAMB2 mouse monoclonal antibody, clone OTI3B4 (formerly 3B4)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-LAMB2 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808897)(1:150) Mouse IgG1 OTI3B4 Purified Hu P, WB
0.1 ml / €360.00
  OriGene Technologies, Inc.


Laminin beta-2 antibody

Immunohistochemistry analysis of Laminin beta-2 antibody (Cat.-No AP01289PU-N) in paraffin-embedded lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  OriGene Technologies GmbH

Laminin beta-2 (C-term) antibody

Western blot analysis of LAMB2 Antibody (C-term) (AP17535PU-N) in A2058 cell line lysates (35ug/lane). LAMB2 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €415.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Laminin beta-2

  Recombinant protein of human laminin, beta 2 (laminin S) (LAMB2)  
Laminin beta-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €788.00
  OriGene Technologies, Inc.

5 Item(s)

per page
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