Laminin gamma 2 / Laminin-5 antibody

Principal name

Laminin gamma 2 / Laminin-5 antibody

Alternative names for Laminin gamma 2 / Laminin-5 antibody

LAMC2, LAMB2T, LAMNB2, Laminin subunit gamma-2, Laminin 5 gamma 2 subunit, Laminin B2t chain, CSF 140 kDa subunit, Ladsin 140 kDa subunit, Large adhesive scatter factor 140 kDa subunit, Cell-scattering factor 140 kDa subunit, Kalinin/nicein/epiligrin 100 kDa subunit

SwissProt ID

Q13753 (Human), Q61092 (Mouse)

Gene ID

3918 (LAMC2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Laminin gamma 2 / Laminin-5 antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq]

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Laminin gamma 2 / Laminin-5 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LAMC2 (RC218516, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LAMC2. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Laminin gamma 2 / Laminin-5 antibody

LAMC2 polyclonal antibody (A01), Lot # 051003JC01. Western Blot analysis of LAMC2 expression in NIH/3T3. Mouse Serum Hu, Ms E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Laminin gamma 2 / Laminin-5 antibody

Laminin gamma 2 / Laminin-5 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Laminin gamma 2 / Laminin-5 antibody

ELISA: LAMC2 Antibody [17370002] Rabbit Hu E, WB
50 µg / €440.00
  Novus Biologicals Inc.

Laminin gamma 2 / Laminin-5 antibody

Immunohistochemistry-Paraffin: LAMC2 Antibody [NBP1-88576] Immunohistochemical staining of human oral mucosa shows distinct positivity in basement membrane of squamous epithelia. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Laminin gamma 2 / Laminin-5 (transcript variant 2)

Laminin gamma 2 / Laminin-5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Laminin gamma 2 / Laminin-5 (transcript variant 1)

Laminin gamma 2 / Laminin-5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Laminin gamma 2 / Laminin-5

Laminin gamma 2 / Laminin-5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Laminin gamma 2 / Laminin-5

Laminin gamma 2 / Laminin-5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

LAMC2 overexpression lysate

LAMC2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

LAMC2 overexpression lysate

LAMC2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

LAMC2 overexpression lysate

LAMC2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

12 Item(s)

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