LASS1 antibody

Principal name

LASS1 antibody

Alternative names for LASS1 antibody

LASS1, LAG1, UOG1, LAG1 longevity assurance homolog 1, Longevity assurance gene 1 protein homolog 1

SwissProt ID

P27544 (Human)

Gene ID

10715 (CERS1)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Por (Porcine), Eq (Equine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of LASS1 antibody

LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein.

General readings

Venkataraman K, Riebeling C, Bodennec J, Riezman H, Allegood JC, Sullards MC, Merrill AH Jr, Futerman AH. Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. J Biol Chem. 2002 Sep 20;277(38):35642-9. Epub 2002 Jun 24. PMID: 12105227

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LASS1 antibody

TA305879 (1ug/ml) staining of Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LASS1 antibody

WB Suggested Anti-CERS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: OVCAR-3 cell lysate Rabbit IgG Purified Eq, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

LASS1 control peptide

LASS1 Purified
50 µg / €210.00
  Acris Antibodies GmbH

LASS1 (Cross reacts with GDF1) antibody

Western blot analysis using LAG1 longevity assurance homolog 1 (AP05285PU-N) at 5  µg/ml on human brain lysate 14 µg/lane. Lane A] antibody alone, Lane B] antibody with 45 µg blocking peptide, Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution. Exposure for 5 min. Rabbit Aff - Purified Hu WB
0.1 mg / €480.00
  Acris Antibodies GmbH

LASS1 (Cross reacts with GDF1) antibody

LASS1 Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

LASS1 control peptide

LASS1 Purified
50 µg / €210.00
  Acris Antibodies GmbH

LASS1 (non-reactive with GDF1) antibody

Western blot analysis using Lass 1 (AP05286PU-N) at 5 µg/ml on Human Brain lysate 14 µg/lane. Lane A] antibody alone, Lane B] antibody with 45 µg peptide, Lane C] antibody with nonspecific peptide, D]conjugate alone.
Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution. Exposure for 5 minutes. Rabbit Aff - Purified Hu WB
0.1 mg / €480.00
  Acris Antibodies GmbH

LASS1 (non-reactive with GDF1) antibody

LASS1 Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

LASS1 antibody

LASS1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

LASS1 antibody

LASS1 Mouse IgG2a 2E8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LASS1 antibody

LASS1 Mouse IgG2a 3F9 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LASS1 antibody

Human OVCAR-3; WB Suggested Anti-LASS1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: OVCAR-3 cell lysate; LASS1 antibody - middle region (ARP49654_P050) in Human OVCAR-3 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

LASS1 antibody

Western Blot: LASS1 Antibody [NBP1-28480]-(1ug/ml) staining of Frontal Cortex lysate (35ug protein in RIPA buffer) Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

LASS1 antibody

Western Blot: LASS1 Antibody [NBP1-59733] - This Anti-LASS1 antibody was used in Western Blot of OVCAR-3     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

LASS1 antibody

Immunohistochemistry-Paraffin: LASS1 Antibody [NBP1-92067] Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LASS1

LASS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

LASS1

LASS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

LASS1

LASS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

LASS1

LASS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CERS1 overexpression lysate

CERS1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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