LASS6 antibody

Principal name

LASS6 antibody

Alternative names for LASS6 antibody

LAG1 longevity assurance homolog 6

SwissProt ID

Q6ZMG9 (Human), Q8C172 (Mouse)

Gene ID

253782 (CERS6), 241447 (Lass6)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of LASS6 antibody

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.

General readings

1: Mizutani Y, Kihara A, Igarashi Y. LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. Biochem J. 2006 Sep 15;398(3):531-8.
2: Schulz A, Mousallem T, Venkataramani M, Persaud-Sawin DA, Zucker A, Luberto C, Bielawska A, Bielawski J, Holthuis JC, Jazwinski SM, Kozhaya L, Dbaibo GS, Boustany RM. The CLN9 protein, a regulator of dihydroceramide synthase. J Biol Chem. 2006 Feb 3;281(5):2784-94. Epub 2005 Nov 22.
3: Weinmann A, Galle PR, Teufel A. LASS6, an additional member of the longevity assurance gene family. Int J Mol Med. 2005 Nov;16(5):905-10.
4: Mizutani Y, Kihara A, Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263-71.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LASS6 antibody

  Rabbit Polyclonal LASS6 Antibody  
Western blot analysis of LASS6 in rat brain tissue lysate with LASS6 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LASS6 antibody

  Rabbit Polyclonal Anti-LASS6 Antibody  
WB Suggested Anti-LASS6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: COLO205 cell lysate;CERS6 is strongly supported by BioGPS gene expression data to be expressed in Human COLO205 cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

LASS6 antibody

  Rabbit Polyclonal Anti-CERS6 Antibody  
LASS6 Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

LASS6 Control Peptide

LASS6 Purified
50 µg / €220.00
  Acris Antibodies GmbH

LASS6 antibody

Western blot analysis using LAG1 longevity assurance homolog 6 at 6 µg/ml on human Duodenum lysate 14 µg/lane. Lane A] antibody alone, Lane B] antibody plus 50 µg blocking peptide, Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution. Exposure for 1.5 minutes. Rabbit Aff - Purified Hu WB
0.1 mg / €490.00
  Acris Antibodies GmbH

LASS6 antibody

Western blot analysis using LAG1 longevity assurance homolog 6 at 6 µg/ml on human Duodenum lysate 14 µg/lane. Lane A] antibody alone, Lane B] antibody plus 50 µg blocking peptide, Lane C] conjugate alone. Visualized using Pierce West Femto substrate system. Anti Rabbit secondary used at 1:3.5K dilution. Exposure for 1.5 minutes Rabbit Purified Hu WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CERS6 - human gene knockout kit via CRISPR

CERS6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CERS6 - human gene knockout kit via CRISPR

CERS6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CERS6 - human gene knockout kit via CRISPR

CERS6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CERS6 - human gene knockout kit via CRISPR

CERS6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cers6 - mouse gene knockout kit via CRISPR

Cers6 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cers6 - mouse gene knockout kit via CRISPR

Cers6 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cers6 - mouse gene knockout kit via CRISPR

Cers6 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cers6 - mouse gene knockout kit via CRISPR

Cers6 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LASS6

  Recombinant protein of human LAG1 homolog, ceramide synthase 6 (LASS6)  
LASS6 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

CERS6-knockout Cell lysate

CERS6-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cers6 (GFP-tagged) - Mouse LAG1 homolog, ceramide synthase 6 (Lass6), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cers6 (GFP-tagged) - Mouse LAG1 homolog, ceramide synthase 6 (Lass6), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cers6 (Myc-DDK-tagged) - Mouse LAG1 homolog, ceramide synthase 6 (Lass6), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cers6 (Myc-DDK-tagged) - Mouse LAG1 homolog, ceramide synthase 6 (Lass6), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

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