Latrophilin-1 / AGRL1 antibody

Principal name

Latrophilin-1 / AGRL1 antibody

Alternative names for Latrophilin-1 / AGRL1 antibody

LPHN1, KIAA0821, LEC2, Latrophilin-1, Calcium-independent alpha-latrotoxin receptor 1, Lectomedin-2, Adhesion G protein-coupled receptor L1

SwissProt ID

O94910 (Human)

Gene ID

22859 (LPHN1), 65096 (Lphn1)

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Xen (Xenopus), L (Lizard), Bear, Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Latrophilin-1 / AGRL1 antibody

Latrophilins (Latrophilin1-3) are members of the adhesion G-protein coupled receptor subfamily. Like all GPCRs, Latrophilins have seven transmembrane domains and are distinguished by a large extracellular N-termil tail and a large intracellular C-termil tail1. The N-terminus has several cell adhesion domains and undergoes proteolysis after synthesis, while the C-termil has various consensus post-translatiol sites like phosphorylation and palmitoylation. In addition, Latrophilins undergo altertive splicing.Latrophilin-1 was discovered by its ability to bind a-Latrotoxin (a-LTX), a toxin isolated from the black widow spider venom. a-LTX induces exocytosis by creating a Ca2+ influx in the presyptic membrane. a-LTX can also stimulate small vesicle exocytosis in a Ca2+ independent manner. Three receptors have been found to bind a-LTX. Of the three, Latrophilins are responsible for the Ca2+-independent effects of a-LTX2. The binding of a-LTX to Latrophilin-1 increases exocytosis of neurotransmitters.In an attempt to find the tural ligand of Latrophilin-1, Lasso, a splice variant of Teneneurin-2 was discovered to be an endogenous binding partner of the adhesion-GPCR7. Teneneurins are large glycoproteins with a single transmembrane domain. Like Latrophilin-1, Teneneurins are mostly expressed in the brain where they modulate neurite outgrowth, axon guidance and syptogenesis.Regarding the localization of Latrophilins, Latrophilin-1 is expressed predomintly in the brain, Latrophilin-2 is highly expressed in the liver and lung, while Latrophilin-3 is almost exclusively detected in the brain.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Latrophilin-1 / AGRL1 antibody

Immunofluorescence analysis of LOVO cells, using LPHN1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

Latrophilin-1 / AGRL1 antibody

Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates: 1, 2. Anti-Latrophilin-1 (extracellular) antibody, (1:200). 3, 4. Anti-Latrophilin-1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Latrophilin-1 / AGRL1 antibody

WB Suggested Anti-LPHN1 Antibody; Titration: 1.0 ug/ml; Positive Control: Hela Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Latrophilin-1 / AGRL1 (extracell. dom.) (N-term) antibody

Anti-LPHN1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Hst, Hu, L, Mky, Ms, Op, Platypus, Por, Rb, Rt, Xen P
50 µg / €379.00
  OriGene Technologies, Inc.

Latrophilin-1 / AGRL1 antibody

Anti-LPHN1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Eq, Hu, Por
50 µg / €379.00
  OriGene Technologies, Inc.

Latrophilin-1 / AGRL1 antibody

Western Blot analysis of LPHN1 expression in transfected 293T cell line (H00022859-T04) by LPHN1 MaxPab polyclonal antibody.

Lane 1: LPHN1 transfected lysate(20.80 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Latrophilin-1 / AGRL1 antibody

Latrophilin-1 / AGRL1 Mouse IgG2a 4E12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Latrophilin-1 / AGRL1 antibody

Immunofluorescence analysis of LOVO cells, using LPHN1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
50 µg / €205.00
  Assay Biotech

Latrophilin-1 / AGRL1 antibody

Immunofluorescence analysis of LOVO cells, using LPHN1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

Latrophilin-1 / AGRL1 antibody

Immunohistochemistry-Paraffin: LPHN1 Antibody [NBP1-85609] Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Latrophilin-1 / AGRL1

Latrophilin-1 / AGRL1 Human
10 µg / €540.00
  Abnova Taiwan Corp.

Latrophilin-1 / AGRL1

Latrophilin-1 / AGRL1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Latrophilin-1 / AGRL1

Latrophilin-1 / AGRL1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Latrophilin-1 / AGRL1

Latrophilin-1 / AGRL1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Latrophilin-1 / AGRL1

Latrophilin-1 / AGRL1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

15 Item(s)

per page
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