Layilin antibody

Principal name

Layilin antibody

Alternative names for Layilin antibody

LAYN

SwissProt ID

Q6UX15 (Human)

Gene ID

143903 (LAYN)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of Layilin antibody

Layilin is a widely expressed integral membrane hyaluronan receptor and a transmembrane protein with homology to C-type lectins. This protein interacts with the ERM protein family of cytoskeletal membrane linker molecule members, including talin, ezrin, moesin, and radixin. The carboxy-terminal domain of layilin is capable of binding to the amino-terminal domain of radixin. An interdomain interaction between the amino- and the carboxy-terminal domains of radixin inhibits its ability to bind to layilin. Layilin plays an important role in cell adhesion and motility. It is important for the maintenance of the cortical structure in the cell because it mediates signals from the extracellular matrix to the cytoskeleton. In spreading cells, Layilin acts as a membrane-binding site for talin in the peripheral ruffles, and it may play a role in the migration of cells to a wound site.

General readings

Bono P., et al. (2005) Exp Cell Res 1;308(1): 177-87Mark L., et al. (1998) The Journal of Cell Biology 143(2): 429

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Layilin antibody

  Rabbit Polyclonal Anti-LAYN Antibody  
WB Suggested Anti-LAYN Antibody Titration: 0.2-1 ug/ml; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Layilin antibody

  LAYN mouse monoclonal antibody, clone OTI4C11 (formerly 4C11)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LAYN (RC206197, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LAYN. Mouse IgG1 OTI4C11 Purified Hu F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Layilin antibody

  LAYN mouse monoclonal antibody, clone OTI4D3 (formerly 4D3)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LAYN (RC206197, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LAYN. Mouse IgG1 OTI4D3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Layilin antibody

The cell lysates of A549 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LAYN antibody (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT20G8 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Layilin antibody

The cell lysates of A549 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human LAYN antibody (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2b AT20G8 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

LAYN - human gene knockout kit via CRISPR

LAYN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

LAYN - human gene knockout kit via CRISPR

LAYN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

LAYN - human gene knockout kit via CRISPR

LAYN - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

LAYN - human gene knockout kit via CRISPR

LAYN - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Layilin

  Recombinant protein of human layilin (LAYN)  
Layilin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Layilin (22-235, His-tag)

Layilin Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

Layilin (22-235, His-tag)

Layilin Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

LAYN overexpression lysate

LAYN overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, LAYN (mGFP-tagged) - Human layilin (LAYN), 200 uL, >10^7 TU/mL

Lenti ORF particles, LAYN (mGFP-tagged) - Human layilin (LAYN), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, LAYN (Myc-DDK tagged) - Human layilin (LAYN) , 200 uL, >10^7 TU/mL

Lenti ORF particles, LAYN (Myc-DDK tagged) - Human layilin (LAYN) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

15 Item(s)

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