LCP2 antibody

Principal name

LCP2 antibody

Alternative names for LCP2 antibody

LCP2, Lymphocyte cytosolic protein 2, SLP-76 tyrosine phosphoprotein, SLP76, SH2 domain-containing leukocyte protein of 76 kDa

SwissProt ID

P07187 (Drome), P91629 (Dromi), Q13094 (Human), Q60787 (Mouse)

Gene ID

3937 (LCP2)

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Bov (Bovine), Can (Canine), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of LCP2 antibody

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

1. Pivniouk VI, Martin TR, Lu-Kuo JM, Katz HR, Oettgen HC, Geha RS: SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun;103(12):1737-43.
2. Silverman MA, Shoag J, Wu J, Koretzky GA: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol. 2006 Mar;26(5):1826-38.
3. Koretzky GA, Abtahian F, Silverman MA: SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond. Nat Rev Immunol. 2006 Jan;6(1):67-78.
4. Beach D, Gonen R, Bogin Y, Reischl IG, Yablonski D: Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1. J Biol Chem. 2007 Feb
2;282(5):2937-46.
6. Bogin Y, Ainey C, Beach D, Yablonski D: SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Proc Natl Acad Sci U S A. 2007 Apr 17;104 (16):6638-43.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LCP2 (N-term) antibody

TA302947 staining (0.5µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
20 µg / €200.00
  Acris Antibodies GmbH

LCP2 (N-term) antibody

TA302947 staining (0.5µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LCP2 antibody

Western blot analysis of extracts of various cell lines, using LCP2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

LCP2 antibody

Western Blotting analysis (reducing conditions) of whole cell lysate using anti-SLP76 (SLP-76/03). Lane 1: HPB-ALL human peripheral blood T cell leukemia cell line. Lane 2: JURKAT human peripheral blood T cell leukemia cell line. Lane 3: RAMOS human Burkitt lymphoma cell line. Mouse IgG2a AS55 Purified Hu IP, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

LCP2 antibody

LCP2 Mouse IgG2a H76 FITC Hu, Ms F
100 Tests / €440.00
  Acris Antibodies GmbH

LCP2 antibody

MOLT4 total lysate (1% NP40) was resolved by electrophoresis, transferred to nitrocellulose and probed with monoclonal anti-SLP76 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Mouse IgG2a H76 Aff - Purified Hu, Ms F, IP, WB
0.2 ml / €390.00
  Acris Antibodies GmbH

LCP2 antibody

Immunohistochemistry (IHC) analyzes of SLP-76 antibody (Cat.-No.: AP21127PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

LCP2 (216-434) antibody

Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Serum Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

LCP2 antibody

Western Blotting analysis (reducing conditions) of whole cell lysate using anti-SLP76 (SLP-76/03). Lane 1: HPB-ALL human peripheral blood T cell leukemia cell line. Lane 2: JURKAT human peripheral blood T cell leukemia cell line. Lane 3: RAMOS human Burkitt lymphoma cell line. Mouse IgG2b SLP-76/03 Purified Hu, Ms, Por P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

LCP2 antibody

Immunohistochemistry staining of human thymus (paraffin sections) with anti-SLP76 polyclonal. Rabbit Purified Hu P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

LCP2 antibody

Western Blot analysis of LCP2 expression in transfected 293T cell line (H00003937-T01) by LCP2 MaxPab polyclonal antibody.

Lane 1: LCP2 transfected lysate(58.63 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

LCP2 antibody

LCP2 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

LCP2 antibody

Western Blot analysis of LCP2 expression in transfected 293T cell line (H00003937-T02) by LCP2 MaxPab polyclonal antibody.

Lane 1: LCP2 transfected lysate(60.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

LCP2 antibody

LCP2 polyclonal antibody ( Cat # PAB6649 ) staining ( 0.5 µg/ml ) of Jurkat lysate ( RIPA buffer, 35 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

LCP2 pTyr128 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using SLP-76 (Phospho-Tyr128) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

LCP2 pTyr128 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using SLP-76 (Phospho-Tyr128) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

LCP2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SLP-76 (Ab-128) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

LCP2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SLP-76 (Ab-128) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

LCP2 pTyr128 antibody

Western blot analysis of SLP76 (pY128) expression in HeLa H2O2-treated (A); Jurkat (B); Raw264.7 H2O2-treated (C); PC12 H2O2-treated (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

LCP2 pTyr128 antibody

Western blot analysis of SLP76 (pY128) expression in HeLa H2O2-treated (A); Jurkat (B); Raw264.7 H2O2-treated (C); PC12 H2O2-treated (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

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