LDHA antibody

Principal name

LDHA antibody

Alternative names for LDHA antibody

LDH-A, L-lactate dehydrogenase A chain, LDH-M, PIG19, NY-REN-59, LDH muscle subunit, Cell proliferation-inducing gene 19 protein, Renal carcinoma antigen NY-REN-59

SwissProt ID

P00338 (Human), P00339 (Pig), P00340 (Chick), P04642 (Rat), P06151 (Mouse), P13491 (Rabit), P19858 (Bovin)

Gene ID

100009107 (LDHA), 3939, 281274

Available reactivities

Rb (Rabbit), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Bov (Bovine), Por (Porcine)

Available hosts

Goat, Rabbit, Mouse, Sheep

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F), Paraffin Sections (P), ELISA (detection) (E(detection)), Dot blot (Dot), Immunodiffusion (ID), Radioimmunoassay (R), Luminex (LMNX)

Background of LDHA antibody

Lactate dehydrogese (LDH) is a ubiquitous enzyme that catalyzes the inter-conversion of pyruvate and lactate, with simultaneous inter-conversion of DH and D+. Mammalian LDH has five tetrameric isozymes comprising combitions of two subunits (i) A subunit (LDHA or LDHM) predomites in skeletal muscle where it involve in aerobic metabolism and pyruvate reduction (ii) B subunit (LDHB) predomites in cardiac muscle where it helps catalyze aerobic oxidation of pyruvate. Several human cancers such as including rel, breast, gastric, sopharyngeal cancer etc. have higher LDHA levels compared to normal tissues and LDHA upregulation ensures efficient aerobic/glycolytic metabolism for tumor cells with reduced oxygen dependency. Moreover, LDHA also plays an important role in the development, invasion and metastasis of several maligncies and induced suppression of LDHA in cancer cells has been shown to trigger ROS burst, mitochondrial pathway apoptosis and limited tumorigenic potential. Defects in LDHA have also been linked to exertiol myoglobinuria and glycogen storage disease type 11 (GSD11).

General readings

Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010)
Zhuang, L., et al. Mod. Pathol. 23(1):45-53(2010)
Zhao, Y.H., et al. Oncogene 28(42):3689-3701(2009)
Xie, H., et al. Mol. Cancer Ther. 8(3):626-635(2009)
Koukourakis, M.I., et al. Oncology 77(5):285-292(2009)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LDHA antibody

Western Blot: Lactate Dehydrogenase A Antibody [TA336781] - Analysis of Lactate Dehydrogenase A in HeLa whole cell lysates. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LDHA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LDHA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500518) Mouse IgG1 OTI2C11 Purified Hu IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LDHA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LDHA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500531) Mouse IgG1 OTI2B11 Purified Hu IP, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

LDHA antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LDHA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500558) Mouse IgG1 OTI5G10 Purified Hu IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LDHA antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-LDHA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500568) Mouse IgG1 OTI2D11 Purified Hu IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LDHA antibody

Immunohistochemistry-Paraffin: Lactate Dehydrogenase A Antibody (2D11) [NBP1-47822] - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of endometrium tissue using anti-LDHAmouse monoclonal antibody. (Dilution 1:50) Mouse 2D11 Aff - Purified Hu IP, P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

LDHA antibody

Western blot analysis of Jurkat cell and A431 cell lysate using LDHA antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

LDHA (C-term) antibody

Anti-LDHA antibody (0.3µg/ml) staining of Heart (A), Skeletal Muscle (B) and Kidney (C) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LDHA antibody

LDHA ELISA with 5G10 Capture (TA600008) and 2B11 Detection (TA700008) Antibodies. Substrate used: Recombinant Human LDHA (TP309378) Mouse IgG1 OTI5G10 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

LDHA antibody

LDHA ELISA with 5G10 Capture (TA600008) and 2B11 Detection (TA700008) Antibodies. Substrate used: Recombinant Human LDHA (TP309378) Mouse IgG1 OTI2B11 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

LDHA antibody

Immunofluorescence of human HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human LDHA antibody (1:500) with Texas Red (Red). Mouse IgG2b AT1A4 Purified Hu E, ICC/IF, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

LDHA antibody

Immunofluorescence of human HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human LDHA antibody (1:500) with Texas Red (Red). Mouse IgG2b AT1A4 Purified Hu E, ICC/IF, WB
50 µl / €230.00
  Acris Antibodies GmbH

LDHA antibody

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b n.a Purified Hu P
50 µl / €470.00
  Acris Antibodies GmbH

LDHA antibody

LDHA Rabbit IgG Azide Free Bov Dot, E, ICC/IF, ID, IP, R, WB
10 mg / €230.00
  Acris Antibodies GmbH

LDHA antibody

LDHA Rabbit IgG Biotin Bov Dot, E, ICC/IF, ID, IP, R, WB
1 ml / €340.00
  Acris Antibodies GmbH

LDHA antibody

LDHA Rabbit IgG Aff - Purified Bov Dot, E, ICC/IF, ID, IP, R, WB
1 mg / €430.00
  Acris Antibodies GmbH

LDHA antibody

LDHA Sheep IgG Azide Free Rb Dot, E, ICC/IF, ID, IP, R, WB
10 mg / €230.00
  Acris Antibodies GmbH

LDHA antibody

LDHA Sheep IgG Biotin Rb Dot, E, ICC/IF, ID, IP, R, WB
1 ml / €340.00
  Acris Antibodies GmbH

LDHA antibody

LDHA Sheep IgG Aff - Purified Rb Dot, E, ICC/IF, ID, IP, R, WB
1 mg / €430.00
  Acris Antibodies GmbH

LDHA (Center) antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human skin tissue reacted with LDHA Antibody (Center) Cat.-No AP52459PU-N which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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