LDLR antibody

Principal name

LDLR antibody

Alternative names for LDLR antibody

LDLR, Low-density lipoprotein receptor, LDL receptor

SwissProt ID

P01130 (Human), P01131 (Bovin), P20063 (Rabit), P35950 (Crigr), P35951 (Mouse), P35952 (Rat), Q28832 (Pig)

Gene ID

3949 (LDLR), 16835 (Ldlr), 300438

Available reactivities

Bov (Bovine), Hu (Human), Hst (Hamster), Ms (Mouse), Rb (Rabbit), Rt (Rat), Prim (Primate), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of LDLR antibody

LDL Receptor (low-density lipoprotein receptor or LDLR) is a key determint of plasma cholesterol levels and as a ubiquitously expressed cell membrane glycoprotein, it binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells via endocytosis. LDLR is found distributed from plasma membrane to intracellular compartments, cell surface (in the presence of PCSK9) and also localizes to Golgi apparatus as well as early/late endosomes and lysosomes. VLDL, IDL, HDL, and chylomicron remnt are also recognized by LDLR at neutral pH. Receptor-ligand complexes undergo endocytosis via clathrin-coated pits and coated vehicle dispenses to endosomes with LRP6 and ARH (also known as LDLR adaptor protein), connecting LDLR family protein and the endocytic machinery; thereby, acidic condition activates dissociation of interlized ligands. Released ligand particles further travel to lysosomes wherein the ligand is degraded by enzyme, while the receptors recycle back to cell surface. After interlization, LDL particles trigger reduction in HMGCR expression to suppress cholesterol biosynthesis; enhancement of ACAT activity to reduce toxic free cholesterol, and suppression of LDLR synthesis to reduce LDL uptake via SREBPs. Genetic mutations impairing LDLR function results in a condition with extremely elevated serum LDL levels and early onset atherosclerosis known as familial hypercholesterolemia (FH).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LDLR antibody

LDLR Rabbit Purified Hu C, F, WB
0.25 ml / €330.00
  Acris Antibodies GmbH

LDLR antibody

LDLR Rabbit Biotin Hu F
0.25 ml / €400.00
  Acris Antibodies GmbH

LDLR antibody

  Chicken Polyclonal LDL-R Antibody  
Western blot analysis of LDL-R in human liver tissue lysate with LDL-R antibody at (A) 1 and (B) 2 ug/ml. Chicken IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LDLR antibody

  Mouse Monoclonal LDL Receptor Antibody (C7)  
Immunohistochemistry: LDL Receptor Antibody (C7) - Immunohistochemical analysis of LDL Receptor on human liver using anti-LDL Receptor. Mouse IgG2b C7 Purified Bov, Hu
0.1 ml / €325.00
  OriGene Technologies, Inc.

LDLR antibody

  Rabbit Polyclonal Anti-LDLR Antibody  
Host: Rabbit; Target Name: LDLR; Sample Tissue: Fetal Heart lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

LDLR antibody

  Rabbit Polyclonal LDL R Antibody  
Western Blot: LDL Receptor Antibody [TA336722] - Western Blot on HepG2 whole cell lysate. Rabbit Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LDLR antibody

LDLR Mouse IgG2b C7 Purified Bov, Hu F, ICC/IF, WB
50 µg / €320.00
  Acris Antibodies GmbH

LDLR antibody

LDLR Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

LDLR antibody

Western Blot analysis of LDLR expression in transfected 293T cell line (H00003949-T01) by LDLR MaxPab polyclonal antibody.

Lane 1: LDLR transfected lysate(94.6 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

LDLR antibody

Western Blot analysis of LDLR expression in transfected 293T cell line by LDLR monoclonal antibody (M01), clone 5E7.

Lane 1: LDLR transfected lysate(94.6 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 5E7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LDLR antibody

Detection limit for recombinant GST tagged LDLR is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 5E6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LDLR antibody

LDLR Mouse IgG2a 5E6 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

LDLR antibody

Western blot analysis of LDLR expression in Jurkat cell ( Lane 1 ) and NIH/3T3 ( Lane 2 ) cell lysates. Rabbit Bov, Hst, Hu, Ms, Rb, Rt WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

LDLR antibody

LDLR Rabbit Purified Hu, Ms, Prim WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

LDLR (500-550) antibody

Detection of LDL R by Western Blot Rabbit IgG Aff - Purified Hu, Ms, Prim WB
0.1 ml / €370.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

LDLR - human gene knockout kit via CRISPR

LDLR - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

LDLR - human gene knockout kit via CRISPR

LDLR - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

LDLR - human gene knockout kit via CRISPR

LDLR - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

LDLR - human gene knockout kit via CRISPR

LDLR - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ldlr - mouse gene knockout kit via CRISPR

Ldlr - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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