LDLR antibody

Principal name

LDLR antibody

Alternative names for LDLR antibody

LDLR, Low-density lipoprotein receptor, LDL receptor

SwissProt ID

P01130 (Human), P01131 (Bovin), P20063 (Rabit), P35950 (Crigr), P35951 (Mouse), P35952 (Rat), Q28832 (Pig)

Gene ID

3949 (LDLR)

Available reactivities

Chk (Chicken), Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Rb (Rabbit), Mky (Monkey), Prim (Primate), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Rabbit, Chicken, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Functional assay (FN), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of LDLR antibody

LDL Receptor (low-density lipoprotein receptor or LDLR) is a key determint of plasma cholesterol levels and as a ubiquitously expressed cell membrane glycoprotein, it binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells via endocytosis. LDLR is found distributed from plasma membrane to intracellular compartments, cell surface (in the presence of PCSK9) and also localizes to Golgi apparatus as well as early/late endosomes and lysosomes. VLDL, IDL, HDL, and chylomicron remnt are also recognized by LDLR at neutral pH. Receptor-ligand complexes undergo endocytosis via clathrin-coated pits and coated vehicle dispenses to endosomes with LRP6 and ARH (also known as LDLR adaptor protein), connecting LDLR family protein and the endocytic machinery; thereby, acidic condition activates dissociation of interlized ligands. Released ligand particles further travel to lysosomes wherein the ligand is degraded by enzyme, while the receptors recycle back to cell surface. After interlization, LDL particles trigger reduction in HMGCR expression to suppress cholesterol biosynthesis; enhancement of ACAT activity to reduce toxic free cholesterol, and suppression of LDLR synthesis to reduce LDL uptake via SREBPs. Genetic mutations impairing LDLR function results in a condition with extremely elevated serum LDL levels and early onset atherosclerosis known as familial hypercholesterolemia (FH).

General readings

Eden ER, Patel DD, Sun-X-M, Burden JJ, Themis M, Edwards M, Lee P, Neuwirth C, Naoumova RP, Soutar AK: Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1. J Clin Invest 110, 1695-1702 (2002).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LDLR antibody

LDLR Rabbit Purified Hu C, F, WB
0.25 ml / €320.00
  Acris Antibodies GmbH

LDLR antibody

LDLR Rabbit Biotin Hu F
0.25 ml / €390.00
  Acris Antibodies GmbH

LDLR antibody

Western blot analysis of LDL-R in human liver tissue lysate with LDL-R antibody at (A) 1 and (B) 2 ug/ml. Chicken IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LDLR antibody

Immunohistochemistry: LDL Receptor Antibody (C7) - Immunohistochemical analysis of LDL Receptor on human liver using anti-LDL Receptor. Mouse IgG2b C7 Purified Bov, Hu
0.1 ml / €325.00
  OriGene Technologies, Inc.

LDLR antibody

Host: Rabbit; Target Name: LDLR; Sample Tissue: Fetal Heart lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

LDLR antibody

Western Blot: LDL Receptor Antibody [TA336722] - Western Blot on HepG2 whole cell lysate. Rabbit Purified Hu, Ms C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LDLR (499-511) antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

LDLR Control Peptide

LDLR
50 µg / €160.00
  Acris Antibodies GmbH

LDLR antibody

LDLR Mouse IgG2b C7 Purified Bov, Hu F, ICC/IF, WB
50 µg / €310.00
  Acris Antibodies GmbH

LDLR antibody

LDLR Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

LDLR antibody

Western Blot analysis of LDLR expression in transfected 293T cell line (H00003949-T01) by LDLR MaxPab polyclonal antibody.

Lane 1: LDLR transfected lysate(94.6 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

LDLR antibody

Western Blot analysis of LDLR expression in transfected 293T cell line by LDLR monoclonal antibody (M01), clone 5E7.

Lane 1: LDLR transfected lysate(94.6 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 5E7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LDLR antibody

Detection limit for recombinant GST tagged LDLR is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 5E6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LDLR antibody

LDLR Mouse IgG2a 5E6 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

LDLR antibody

Western blot analysis of LDLR expression in Jurkat cell ( Lane 1 ) and NIH/3T3 ( Lane 2 ) cell lysates. Rabbit Bov, Hst, Hu, Ms, Rb, Rt WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

LDLR antibody

LDLR Rabbit Purified Hu, Ms, Prim WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

LDLR (500-550) antibody

Detection of LDL R by Western Blot Rabbit IgG Aff - Purified Hu, Ms, Prim WB
0.1 ml / €370.00
  Neuromics Antibodies

LDLR (C-term) antibody

Immunohistochemistry: LDL Receptor Antibody (EP1553Y) [NB110-57162] - Immunohistochemical staining of paraffin-embedded human liver. Rabbit IgG EP1553Y Supernatant Hu, Ms, Rt F, ICC/IF, IP, P, WB
0.1 ml / €490.00
  Novus Biologicals Inc.

LDLR antibody

LDLR Mouse IgG1 8B8 Purified Rb C, F, P, WB
50 µg / €260.00
  Novus Biologicals Inc.

LDLR antibody

LDLR Rabbit Biotin Hu, Mky, Ms WB
0.1 ml / €360.00
  Novus Biologicals Inc.

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