LEFTY1 antibody

Principal name

LEFTY1 antibody

Alternative names for LEFTY1 antibody

LEFTY1, LEFTB, LEFTYB, Left-right determination factor 1, Protein lefty-1, Left-right determination factor B, Protein lefty-B

SwissProt ID

O75610 (Human), Q64280 (Mouse)

Gene ID

10637 (LEFTY1), 13590 (Lefty1)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of LEFTY1 antibody

During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LEFTY1 antibody

  Rabbit Polyclonal Anti-LEFTY1 Antibody  
WB Suggested Anti-LEFTY1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

LEFTY1 (C-term) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LEFTB antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

LEFTY1 antibody

LEFTY1 Rat IgG2 8B65 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Lefty1 - mouse gene knockout kit via CRISPR

Lefty1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Lefty1 - mouse gene knockout kit via CRISPR

Lefty1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lefty1 - mouse gene knockout kit via CRISPR

Lefty1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lefty1 - mouse gene knockout kit via CRISPR

Lefty1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

LEFTY1 overexpression lysate

LEFTY1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, LEFTY1 (mGFP-tagged) - Human left-right determination factor 1 (LEFTY1), 200 uL, >10^7 TU/mL

Lenti ORF particles, LEFTY1 (mGFP-tagged) - Human left-right determination factor 1 (LEFTY1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, LEFTY1 (Myc-DDK tagged) - Human left-right determination factor 1 (LEFTY1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, LEFTY1 (Myc-DDK tagged) - Human left-right determination factor 1 (LEFTY1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Lefty1 (GFP-tagged) - Mouse left right determination factor 1 (Lefty1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Lefty1 (GFP-tagged) - Mouse left right determination factor 1 (Lefty1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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