LEFTY1 antibody

Principal name

LEFTY1 antibody

Alternative names for LEFTY1 antibody

LEFTY1, LEFTB, LEFTYB, Left-right determination factor 1, Protein lefty-1, Left-right determination factor B, Protein lefty-B

SwissProt ID

O75610 (Human), Q64280 (Mouse)

Gene ID

10637 (LEFTY1), 13590 (Lefty1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of LEFTY1 antibody

During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LEFTY1 antibody

WB Suggested Anti-LEFTY1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

LEFTY1 (C-term) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LEFTB antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

LEFTY1 antibody

LEFTY1 Rat IgG2 8B65 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

LEFTY1 antibody

LEFTY1 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

LEFTY1 antibody

Western Blot analysis of LEFTY1 expression in transfected 293T cell line (H00010637-T01) by LEFTY1 MaxPab polyclonal antibody.

Lane1:LEFTY1 transfected lysate(40.26 KDa).
Lane2:Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 Mouse IgG2a 4D7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 Mouse IgG2a 1F9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 monoclonal antibody (M03), clone 2E10 Western Blot analysis of LEFTY1 expression in THP-1 ( Cat # L007V1 ). Mouse IgG2a 2E10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 Mouse IgG2a 4A3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 Mouse IgG2a 2B9 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

LEFTY1 Mouse IgG2a 3B5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LEFTY1 antibody

Western blot analysis of LEFTY1 polyclonal antibody ( Cat # PAB2064 ) in HL-60 cell line lysates ( 35 µg/lane ) . LEFTY1 ( arrow ) was detected using the purified Polyclonal antibody ( 1 : 60 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

LEFTY1 antibody

Transfected 293T; WB Suggested Anti-LEFTY1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Transfected 293T; LEFTY1 antibody - N-terminal region (ARP52390_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

LEFTY1 antibody

LEFTY1 Rat IgG2 RM0121-8B65 Purified Ms WB
0.1 mg / €450.00
  Novus Biologicals Inc.

LEFTY1 antibody

Western Blot: Lefty Antibody [NBP1-59323] - This Anti-LEFTY1 antibody was used in Western Blot of Transfected 293T tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LEFTY1

LEFTY1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

LEFTY1

LEFTY1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

LEFTY1

LEFTY1 Human
10 µg / €380.00
  Abnova Taiwan Corp.

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