LEFTY2 antibody

Principal name

LEFTY2 antibody

Alternative names for LEFTY2 antibody

LEFTY2, EBAF, LEFTA, LEFTYA, TGFB4, Left-right determination factor 2, Protein lefty-2, Left-right determination factor A, Protein lefty-A, Transforming growth factor beta-4, TGF-beta-4, Endometrial bleeding-associated factor

SwissProt ID

O00292 (Human), P57785 (Mouse)

Gene ID

7044 (LEFTY2), 320202 (Lefty2)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog, Can (Canine), Eq (Equine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of LEFTY2 antibody

During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.

General readings

Cornet,P.B., (2005) J. Clin. Endocrinol. Metab. 90 (2), 1001-1011

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LEFTY2 antibody

  Rabbit polyclonal antibody to Lefty -A (left-right determination factor 2)  
Sample (30 ug of whole cell lysate). A: A431 . 10% SDS PAGE. TA308258 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LEFTY2 antibody

  Mouse monoclonal LEFTY A antibody  
Mab anti-Human LEFTY antibody to detect by WB partially purified recombinant 6X His tagged human LEFTY. The blot was incubated with a 1:2,000 dilution of Mab anti-Human LEFTY at RT for 30 min followed by detection using IRDye™800 labeled Goat-a-Mouse IgG [H&L] diluted 1:1,000. Lane 1 contains an unrelated 6X His tagged protein and shows that the antibody does not recognize the epitope tag. Lane 2 contains partially purified recombinant human LEFTY. Mouse IgG2a 7C5G1H6H10 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

LEFTY2 antibody

  Rabbit Polyclonal Anti-LEFTY2 Antibody  
WB Suggested Anti-LEFTY2 Antibody Titration: 0.2-1 ug/ml; Positive Control: RPMI 8226 cell lysate.LEFTY2 is supported by BioGPS gene expression data to be expressed in RPMI 8226 Rabbit IgG Purified Bov, Eq, Hu, Ms, Por, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

LEFTY2 antibody

  Rabbit Polyclonal Anti-LEFTY2 Antibody  
Host: Rabbit; Target Name: LEFTY2; Sample Tissue: Thymus Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Can, Hu, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

LEFTY2 antibody

  Rabbit Polyclonal Anti-LEFTY2 Antibody  
Gel: 8%SDS-PAGE,Lysate: 40 ug,,Primary antibody: (LEFTY2 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

LEFTY2 - human gene knockout kit via CRISPR

LEFTY2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

LEFTY2 - human gene knockout kit via CRISPR

LEFTY2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

LEFTY2 - human gene knockout kit via CRISPR

LEFTY2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

LEFTY2 - human gene knockout kit via CRISPR

LEFTY2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lefty2 - mouse gene knockout kit via CRISPR

Lefty2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Lefty2 - mouse gene knockout kit via CRISPR

Lefty2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lefty2 - mouse gene knockout kit via CRISPR

Lefty2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lefty2 - mouse gene knockout kit via CRISPR

Lefty2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, LEFTY2 (mGFP-tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, LEFTY2 (mGFP-tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, LEFTY2 (mGFP-tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, LEFTY2 (mGFP-tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, LEFTY2 (Myc-DDK tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, LEFTY2 (Myc-DDK tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, LEFTY2 (Myc-DDK tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, LEFTY2 (Myc-DDK tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Lefty2 (GFP-tagged) - Mouse left-right determination factor 2 (Lefty2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Lefty2 (GFP-tagged) - Mouse left-right determination factor 2 (Lefty2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Lefty2 (Myc-DDK-tagged) - Mouse left-right determination factor 2 (Lefty2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Lefty2 (Myc-DDK-tagged) - Mouse left-right determination factor 2 (Lefty2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

19 Item(s)

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