LGR4 / GPR48 antibody

Principal name

LGR4 / GPR48 antibody

Alternative names for LGR4 / GPR48 antibody

G-protein coupled receptor 48, Leucine-rich repeat-containing G-protein coupled receptor 4

SwissProt ID

A2ARI4 (Mouse), Q9BXB1 (Human), Q9Z2H4 (Rat)

Gene ID

55366 (LGR4), 107515 (Lgr4)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Bear, Chimp (Chimpanzee), Macaque, Orang-Utan, Hst (Hamster), Bt (Bat), Chk (Chicken), Eq (Equine)

Available hosts

Rabbit, Mouse, Rat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of LGR4 / GPR48 antibody

LGR4 (Leucine-rich repeat- containing G protein-coupled receptor 4) belongs to the superfamily of G protein-coupled receptors (GPCRs). It is a 951 amino acid multi-pass membrane protein and has multiple N-terminal leucine-rich repeats, which are important for interaction with the glycoprotein ligands, and 7 transmembrane domains (1,3). LGR4 is highly expressed in the adult human pancreas but also with moderate levels of expression in placenta, kidney, brain and heart (2). LGR4 functions as an orphan receptor that may be involved in physiologic activities throughout the cell. It is overexpressed in various cancer types and is thought to enhance carcinoma invasiveness and metastasis, suggesting an important role in tumor progression.

General readings

1. Weng,J., Luo,J., Cheng,X., Jin,C., Zhou,X., Qu,J., Tu,L., Ai,D.,Li,D., Wang,J., Martin,J.F., Amendt,B.A. and Liu,M.(2008) Deletion of G proteincoupled
receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc. Natl. Acad. Sci. U.S.A. 105 (16), 6081-6086.
2. Gao,Y., Kitagawa,K., Hiramatsu,Y., Kikuchi,H., Isobe,T., Shimada,M., Uchida,C., Hattori,T., Oda,T., Nakayama,K., Nakayama,K.I., Tanaka,T., Konno,H. and Kitagawa,M. (2006) Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 66 (24), 11623-11631.
3. Loh,E.D., Broussard,S.R. and Kolakowski,L.F. (2001) Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. Biochem. Biophys. Res. Commun. 282 (3), 757-764.
4. Loh,E.D., Broussard,S.R., Liu,Q., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Kolakowski,L.F. Jr. (2000) Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. Cytogenet. Cell Genet. 89 (1-2), 2-5.
5. Hsu,S.Y., Liang,S.G. and Hsueh,A.J. (1998) Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol. Endocrinol. 12 (12), 1830-1845.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LGR4 / GPR48 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGR4 (RC221345, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR4. Mouse IgG1 OTI2D1 Purified Hu F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

LGR4 / GPR48 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LGR4 (RC221345, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR4. Mouse IgG1 OTI5B8 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LGR4 / GPR48 (N-term, extracell. dom.) antibody

Anti-GPR48 / LGR4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Elephant, Hu, Mky, Ms, Por, Prim, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

LGR4 / GPR48 antibody

Western blot analysis of extracts from Jurkat cells, using LGR4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LGR4 / GPR48 antibody

Anti-LGR4 monoclonal antibody was used diluted to 5 ug/ml to detect LGR4 staining at the membrane of cells in various human tissues. A. Brain cerebellum. B. Pancreas islet. Mouse IgG2b 6G8.B3.G5.C3 Purified Chimp, Hu, Macaque, Orang-Utan E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LGR4 / GPR48 (C-term) antibody

Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt, Tr, Xen P
50 µg / €379.00
  OriGene Technologies, Inc.

LGR4 / GPR48 antibody

Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky, Por, Rb
50 µg / €379.00
  OriGene Technologies, Inc.

LGR4 / GPR48 antibody

Anti-LGR4 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Bt, Can, Chk, Eq, Hu, Ms, Por, Rt
50 µg / €379.00
  OriGene Technologies, Inc.

LGR4 / GPR48 antibody

Anti-LGR4 antibody IHC of human brain, caudate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

LGR4 / GPR48 antibody

Anti-LGR4 monoclonal antibody was used diluted to 5 ug/ml to detect LGR4 staining at the membrane of cells in various human tissues. A. Brain cerebellum. B. Pancreas islet. Mouse IgG2b 6G8.B3.G5.C3 Purified Chimp, Hu, Macaque, Orang-Utan E, P, WB
25 µl / €190.00
  Acris Antibodies GmbH

LGR4 / GPR48 antibody

FACS analysis of BOSC23 cells using BBX-3A8 Cat.-No AM32985PU-N. BOSC23 cells were transiently transfected with an expression vector encoding either LGR4-hum (red curve), LGR4-murine (blue curve) or an irrelevant protein (control transfectant: black curve). Binding of BBX-3A8 was detected with a PE-conjugated secondary antibody. A positive signal was obtained with LGR4- hum and LGR4-mur transfected cells. Rat IgG2a BBX-3A8 Purified Hu, Ms E, F
0.1 mg / €330.00
  Acris Antibodies GmbH

LGR4 / GPR48 antibody

FACS analysis of BOSC23 cells using BBX-1H1 Cat.-No AP32978PU-N. BOSC23 cells were transiently transfected with an expression vector encoding either LGR4-hum (red curve), LGR4-murine (blue curve) or an irrelevant protein (control transfectant: black curve). Binding of BBX-3A8 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with LGR4-hum transfected cells. Rat IgG2a BBX-1H1 Purified Hu E, F
0.1 mg / €330.00
  Acris Antibodies GmbH

LGR4 / GPR48 antibody

LGR4 / GPR48 Mouse IgG2a 8F6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LGR4 / GPR48 antibody

Western blot analysis of extracts from Jurkat cells, using LGR4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

LGR4 / GPR48 antibody

Western blot analysis of extracts from Jurkat cells, using LGR4 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

LGR4 / GPR48 antibody

LGR4 / GPR48 Mouse IgG2a 12H6 Purified Hu F, WB
50 µg / €700.00
  Funakoshi Co., Ltd.

LGR4 / GPR48 antibody

LGR4 / GPR48 Mouse 6G8.B3.G5.C3 Purified Hu, Mky E, P, WB
1 mg / €2,050.00
  Novus Biologicals Inc.

LGR4 / GPR48 antibody

Immunohistochemistry-Paraffin: GPCR GPR48 Antibody [NBP1-89737] - Immunohistochemical staining of human breast shows strong positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LGR4 / GPR48

LGR4 / GPR48 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

LGR4 / GPR48

LGR4 / GPR48 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

20 Item(s)

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