LGR5 / GPR49 antibody

Principal name

LGR5 / GPR49 antibody

Alternative names for LGR5 / GPR49 antibody

G-protein coupled receptor 49, GPR67, HG38, Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor HG38, G-protein coupled receptor 67

SwissProt ID

O75473 (Human), Q9Z1P4 (Mouse)

Gene ID

8549 (LGR5)

Available reactivities

Bt (Bat), Bov (Bovine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Rb (Rabbit), Rt (Rat), Bear, Por (Porcine)

Available hosts

Rabbit, Mouse, Rat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), Frozen Sections (C)

Background of LGR5 / GPR49 antibody

GPR49/LGR5 (G protein-coupled receptor 49 / leucine-rich repeat-containing G protein-coupled receptor 5), also called FEX, GPR67, GRP49, HG38 or MGC117008), is structurally related to members of glycoprotein hormone receptor family including FSH-R, TSH-R and LH-R. LGRs (leucine-rich repeat-containing G-protein coupled receptor) are divided into three major subgroups: glycoprotein hormone receptors; the subgroup of GPR48, GPR49, and LGR6; and receptors of relaxin family ligands (LGR7 and LGR8), of which GPR49 is emerging as a significant player in stem cells biology as it is highly expressed on stem cells in small intestine, colon and hair follicle. Deficiency of GPR49 in mice has been shown to cause neotal lethality characterized by ankyloglossia, gastrointestil distension and induction of premature differentiation of Paneth cells. LGR5 is a downstream target gene of Wnt sigling pathway (critical for morphogenesis and tumorigenesis) and it has also been reported as a receptor for R-spondins which are potent mediators of Wnt/beta-catenin as well as Wnt/PCP sigling. Accordingly, when compared to normal tissues, LGR5 is found upregulated in certain cancers e.g liver cancer with beta-catenin mutations, basal cell carcinoma, colon and ovarian carcinomas.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LGR5 / GPR49 antibody

HT29 cells are fixed with 2% formaldehyde for 20 min at RT, then stained with PE-labeled 2A2 anti-Lgr5 antibody. Black line: isotope control; Red line: anti-Lgr5-PE. Mouse IgG1 OTI2A2 Purified Hu, Ms F
0.1 ml / €350.00
  OriGene Technologies, Inc.

LGR5 / GPR49 antibody

HT29 cells are fixed with 2% formaldehyde for 20 min at RT, then stained with DyLight 488-labeled 2A2 anti-Lgr5 antibody. Black line: isotope control; Red line: anti-Lgr5-DyLight 488. Mouse IgG1 OTI2A2 Purified Hu, Ms F
0.1 ml / €325.00
  OriGene Technologies, Inc.

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503316) Mouse IgG1 OTI2A2 Purified Hu, Ms F, ICC/IF, IP, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

LGR5 / GPR49 (1st cytoplasm. dom.) antibody

Human Colon: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bear, Bov, Bt, Elephant, Hst, Hu, Mky, Ms, Op, Rb, Rt ICC/IF, P
50 µg / €379.00
  OriGene Technologies, Inc.

LGR5 / GPR49 (N-term, extracell. dom.) antibody

Human, Pancreas, Islets: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Bt, Elephant, Hu, Mky, Ms, Op, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 Mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800102)(1:150) Mouse IgG2a UMAB210 Purified Hu, Ms F, ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800103)(1:150) Mouse IgG2a UMAB211 Purified Hu F, ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800104)(1:150) Mouse IgG2a UMAB212 Purified Hu F, ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

LGR5 / GPR49 antibody

Flow cytometric analysis of the stable expression of LGR5 plasmid (Cat# RC212825) in live NIH3T3 cells using anti-LGR5 antibody (Cat# UM800104HM, clone UMAB212 at 1:50, red) compared to a nonspecific negative control antibody (black). Mouse IgG2a UMAB212 PE Hu, Ms F
0.1 ml / €120.00
  OriGene Technologies, Inc.

UltraMAB

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 Mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800102)(1:150) Mouse IgG2a UMAB210 Purified Hu, Ms F, ICC/IF, P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800103)(1:150) Mouse IgG2a UMAB211 Purified Hu F, ICC/IF, P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800104)(1:150) Mouse IgG2a UMAB212 Purified Hu F, ICC/IF, P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

LGR5 / GPR49 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGR5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502948) Mouse IgG2a OTI2H7 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LGR5 / GPR49 antibody

LGR5 / GPR49 Mouse IgG2a OTI3F1 Purified Hu, Ms F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LGR5 / GPR49 antibody

LGR5 / GPR49 Mouse IgG2a OTI7F2 Purified Hu, Ms F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LGR5 / GPR49 (Loop2) antibody

Fluorescent confocal image of HeLa cells stained with LGR5 (loop2) antibody AP12376PU-N. HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated with AP2745d LGR5 (loop2) primary antibody (1:100, 2 h at room temperature). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 ?g/ml, 5 min). Note the highly specific localization of the LGR5 immunosignal to the nucleus and cytoplasm, supported by Human Protein Atlas Data Rabbit Ig Aff - Purified Hu, Ms, Rt F, ICC/IF, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

LGR5 / GPR49 antibody

Predicted cell location: Cytoplasm,Nucleus. Positive control: Human brain tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using LGR5 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

LGR5 / GPR49 antibody

LGR5/GPR49 Antibody (N-term) (Cat.#TA324730) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Rabbit IgG Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

LGR5 / GPR49 antibody

Immunohistochemistry: GPR49/LGR5 Antibody [TA336750] - Analysis of human small intestine. Rabbit Purified Hu, Por C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LGR5 / GPR49 antibody

Anti-GPR49 / LGR5 antibody IHC of human human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

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