LIMK1 antibody

Principal name

LIMK1 antibody

Alternative names for LIMK1 antibody

LIMK, LIM domain kinase 1, LIMK-1, EC=2.7.11.1

SwissProt ID

O42565 (Xenla), P53667 (Human), P53668 (Mouse), P53669 (Rat), Q8IR79 (Drome), Q8QFP8 (Chick)

Gene ID

3984 (LIMK1), 16885 (Limk1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Orang-Utan, Bov (Bovine), Can (Canine), Fe (Feline), Chk (Chicken), Mky (Monkey)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of LIMK1 antibody

LIMK1, a member of the Ser/Thr protein kinase family, may be a component of an intracellular signaling pathway and may be involved in brain development. It phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes. The LIM domain interacts with the cytoplasmic domain of NRG1, and this cytoplasmic protein also binds ROCK1, whic phosphorylates LIMK1 on serine and/or threonine residues. Highest expression occurs in both adult and fetal nervous systems. It is detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex, and is expressed to a lesser extent in heart and skeletal muscle. Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23. This protein contains 2 LIM zinc-binding domains and 1 PDZ/DHR domain.

General readings

1. Ray S  et al. LIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis. Mol Biol Cell 25:2393-407 (2014).PubMed: 24966172
2. Loubet D  et al. Neuritogenesis: the prion protein controls ß1 integrin signaling activity.FASEB J 26:678-90 (2012). WB ; Mouse .PubMed: 22038049
3. Tondeleir D  et al. Cells lacking ß-actin are genetically reprogrammed and maintain conditional migratory capacity. Mol Cell Proteomics 11:255-71 (2012). WB .PubMed: 22448045
4. McNair K  et al. A role for RhoB in synaptic plasticity and the regulation of neuronal morphology. J Neurosci 30:3508-17 (2010). WB ; Mouse .PubMed: 20203211
5. Mokalled MH  et al. Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development.Development 137:2365-74 (2010). IHC-P ; Human .PubMed: 20534669
6. Carcea I  et al. Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A. J Neurosci 30:15317-29 (2010). ICC/IF ; Rat .PubMed: 21068336
7. Montani L  et al. Neuronal Nogo-A Modulates Growth Cone Motility via Rho-GTP/LIMK1/Cofilin in the Unlesioned Adult Nervous System. J Biol Chem 284:10793-807 (2009). WB, ICC/IF ; Mouse .PubMed: 19208621

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LIMK1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-LIMK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502904) Mouse IgG2b OTI3H6 Purified Hu, Mky, Ms, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-LIMK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502975) Mouse IgG2b OTI3G3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-LIMK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502978) Mouse IgG2a OTI8C8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-LIMK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503012) Mouse IgG2a OTI6B4 Purified Can, Hu, Mky, Ms, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-LIMK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503122) Mouse IgG2b OTI2A11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1A8 Purified Hu, Ms, Rt E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

LIMK1 antibody

Immunoperoxidase of monoclonal antibody to LIMK1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Mouse IgG2a 1A8 Purified Hu, Ms, Rt E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LIMK1 antibody

Western blot analysis of extracts from mouse brain cells, using LIMK1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LIMK1 (630-647) antibody

WB using Anti-LIM Kinase antibody shows detection of a 73 kDa band corresponding to LIM kinase in lysates from mouse brain. Approximately 18 ug of lysate was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-LIM kinase antibody. The doublet band at ~75 kDa may represent phosphorylated and non-phosphorylated forms of the protein. The identity of the strong lower molecular weight band at approximately 20 kDa is unknown. Rabbit IgG Aff - Purified Chimp, Hu, Ms, Orang-Utan, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LIMK1 antibody

Western blot analysis of LIMK1 expression in UV treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LIMK1 antibody

Western blot analysis of LIMK1/2 expression in COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LIMK1 antibody

Anti-LIMK1 mouse monoclonal antibody (TA502974) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LIMK1(RC218058). Mouse IgG2a OTI6A7 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Anti-LIMK1 mouse monoclonal antibody (TA502977) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LIMK1(RC218058). Mouse IgG2a OTI8B2 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Anti-LIMK1 mouse monoclonal antibody (TA503007) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LIMK1(RC218058). Mouse IgG2b OTI 7C3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Anti-LIMK1 mouse monoclonal antibody (TA503162) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LIMK1(RC218058). Mouse IgG2b OTI1F1 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Anti-LIMK1 mouse monoclonal antibody (TA503201) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LIMK1(RC218058). Mouse IgG2a OTI3A3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

LIMK1 antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 2E9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

LIMK1 antibody

LIMK1 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €390.00
  Acris Antibodies GmbH

LIMK1 pThr508 antibody

Immunohistochemistry (IHC) analysis of LIMK1 pThr508 antibody (Cat.-No.: AP01627PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

LIMK1 pThr508 antibody

Figure 1. Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue, using LIMK1 (phospho-Thr508) antibody (#AP02414PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

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