LIN28B antibody

Principal name

LIN28B antibody

Alternative names for LIN28B antibody

LIN28B, CSDD2, Lin-28 homolog B

SwissProt ID

Q6ZN17 (Human)

Gene ID

389421 (LIN28B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Immunoprecipitation (IP)

Background of LIN28B antibody

Lin-28 homolog B (LIN28B) is overexpressed in hepatocellular carcinoma. The heterochronic gene lin-28 is a key regulator of developmental timing in the nematode Caenorhabditis elegans. Similar with lin-28 proteins, LIN28B conserves a cold shock domain and a pair of CCHC zinc finger domains. Phylogenetic analysis suggests that they might arise as a result of duplication from an ancestral gene. Overexpression of LIN28B was noted in most HCC cell lines and clinical samples. A short LIN28B isoform was also identified in non-tumor liver tissue and fetal liver. Although predominantly localized in the cytoplasm, LIN28B protein shows cell cycle-dependent nuclear translocation in Huh7 cells. Induced expression of exogenous LIN28B in a tet-off cell line promoted cancer cell proliferation.

General readings

Heo I., et al. (2008) Mol. Cell 32:276-284Richards M, et al. (2004) Stem Cells 22 (1): 51–64.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LIN28B antibody

Formalin-fixed and paraffin-embedded human Spleen tissue reacted with LIN28B antibody (Center) (Cat.-No AP11496PU-N), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

LIN28B antibody

Predicted band size: 27 kDa . Positive control: Hela and 293 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2: Hela and 293 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LIN28B (N-term) antibody

Western blot analysis of LIN28B Antibody (N-term) (Cat.#TA324574) in HL60 cell line lysates (35ug/lane). LIN28B (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

LIN28B antibody

Western blot analysis of extracts from Hela and 293 cells using LIN28B Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LIN28B antibody

ELISA: LIN28B Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

LIN28B (C-term) antibody

Western blot analysis of LIN28B Antibody (C-term) in HL60 cell line lysates (35 µg/lane). LIN28B (arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

LIN28B (N-term) antibody

Human Spleen (formalin-fixed, paraffin-embedded) stained with LIN28B antibody AP22769PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

LIN28B antibody

Western blot analysis of LIN28B polyclonal antibody ( Cat # PAB3152 ) in HL-60 cell line lysates ( 35 µg/lane ) . LIN28B ( arrow ) was detected using the purified polyclonal antibody ( 1 : 60 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

LIN28B antibody

Western blot analysis of LIN28B polyclonal antibody ( Cat # PAB3153 ) in HL-60 cell line lysates ( 35 µg/lane ) . LIN28B ( arrow ) was detected using the purified polyclonal antibody ( 1 : 60 dilution ) . Rabbit Hu E, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

LIN28B antibody

Formalin-fixed and paraffin-embedded human testis tissue reacted with LIN28B polyclonal antibody ( Cat # PAB3154 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

LIN28B antibody

ELISA: LIN28B Antibody [45820002] Rabbit Hu E, WB
50 µg / €400.00
  Novus Biologicals Inc.

LIN28B antibody

Immunohistochemistry-Paraffin: Lin28B Antibody [NBP1-50529] - Human Spleen (formalin-fixed, paraffin-embedded) stained with LIN28B antibody followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, F, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

LIN28B antibody

Immunohistochemistry-Paraffin: Lin28B Antibody [NBP1-85438] - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LIN28B (full length, N-term HIS tag)

LIN28B Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

LIN28B (1-250, His-tag)

LIN28B Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €730.00
  Acris Antibodies GmbH

LIN28B (1-250, His-tag)

LIN28B Human Purified > 85 % by SDS - PAGE E. coli
10 µg / €300.00
  Acris Antibodies GmbH

LIN28B

LIN28B Human
10 µg / €380.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

LIN28B overexpression lysate

LIN28B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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