LIN7C antibody
Principal name
LIN7C antibody
Alternative names for LIN7C antibody
LIN7C, MALS3, VELI3, Lin-7 homolog C, Lin-7C, Mammalian lin-seven protein 3, MALS-3, Vertebrate lin-7 homolog 3, Veli-3 protein
SwissProt ID
Q9NUP9 (Human)
Gene ID
55327 (LIN7C)
Ncbi ID
Available reactivities
Available hosts
Available applications
Paraffin Sections (P), Western blot / Immunoblot (WB)
Background of LIN7C antibody
LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
General readings
Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010)
Lanktree, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 945-951 (2008)
Bulgin, N.L., et al. Neuromolecular Med. 10(4):343-355(2008)
Onda, T., et al. Cancer Res. 67(20):9643-9648(2007)
Bohl, J., et al. J. Biol. Chem. 282(13):9392-9400(2007)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP52489PU-N | LIN7C (C-term) antibody |
||||||
 |
Rabbit | Ig | Aff - Purified | Hu | P, WB |
0.4 ml /
€370.00
|
|
| Acris Antibodies GmbH | |||||||
 +1 additional image |
|||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN208758 | LIN7C - human gene knockout kit via CRISPR |
||
 |
Human | GFP-Puro |
1 kit /
€1,200.00
|
| OriGene Technologies, Inc. | |||
| KN208758BN | LIN7C - human gene knockout kit via CRISPR |
||
|
Human | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN208758LP | LIN7C - human gene knockout kit via CRISPR |
||
|
Human | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN208758RB | LIN7C - human gene knockout kit via CRISPR |
||
|
Human | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP308758 | LIN7C |
||||
| Recombinant protein of human lin-7 homolog C (C. elegans) (LIN7C) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
|
|
| OriGene Technologies, Inc. | |||||
| AR50661PU-N | LIN7C (1-197, His-tag) |
||||
 |
Human | Purified | > 90 % by SDS - PAGE | E. coli |
0.5 mg /
€730.00
|
| Acris Antibodies GmbH | |||||
| AR50661PU-S | LIN7C (1-197, His-tag) |
||||
|
Human | Purified | > 90 % by SDS - PAGE | E. coli |
0.1 mg /
€300.00
|
| Acris Antibodies GmbH | |||||
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC208758L2V | Lenti ORF particles, LIN7C (mGFP-tagged) - Human lin-7 homolog C (C. elegans) (LIN7C), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€880.00
|
|
| OriGene Technologies, Inc. | ||
| RC208758L1V | Lenti ORF particles, LIN7C (Myc-DDK tagged) - Human lin-7 homolog C (C. elegans) (LIN7C) , 200 uL, >10^7 TU/mL |
|
|
200 µl /
€780.00
|
|
| OriGene Technologies, Inc. | ||
