LRG47 / IRGM antibody

Principal name

LRG47 / IRGM antibody

Alternative names for LRG47 / IRGM antibody

Immunity-related GTPase family M protein, IFI1, IRGM1, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47

SwissProt ID

A1A4Y4, Q60766, Q6AYC2

Gene ID

345611 (IRGM), 15944 (Irgm1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of LRG47 / IRGM antibody

IRGM belongs to a family of interferon-gamma inducible GTPases, belonging to the GTPase superfamily, and are selectively induced by IFN-gamma or bacterial lipopolysaccharide (LPS) stimulation. IRGM is primarily expressed in all cells derived from B-cell lineages, and is highly expressed in macrophages following IFN-gamma stimulation. IRGM has been shown to be required for host defences against a broad range of intracellular pathogens. Specifically, IRGM deficient mice show defects with intracellular microbial killing, phagosome maturation and autophagy. More recently IRGM has been shown to inhibit baseline hematopoietic proliferation and is required for a normal hematopoietic stem cell response to chemical and infectious stimuli.

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Lysates

Catalog No.    

IRGM overexpression lysate

IRGM overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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