LRP2 antibody

Principal name

LRP2 antibody

Alternative names for LRP2 antibody

Megalin, Glycoprotein 330, LRP-2, Low-density lipoprotein receptor-related protein 2

SwissProt ID

A2ARV4 (Mouse), P98158 (Rat), P98164 (Human)

Gene ID

4036 (LRP2), 29216 (Lrp2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of LRP2 antibody

Megalin, also called Lipoprotein receptor-related protein-2 (LRP2) or glycoprotein 330, is a 600-kDa transmembrane protein belonging to the LDL-receptor family. Members of this receptor family are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Megalin was first discovered in 1982 as the pathogenic antigen of Heymann nephritis. The complete cDNA sequences have been characterized for rat and human Megalin.
The protein contains a single transmembrane domain, is known to act as an endocytic receptor and is expressed primarily on the apical membrane domain of epithelial cells. Both the protein and its mRNA have been identified in human parathyroid cells, placental cytotrophoblasts and epididymal epithelial cells. The protein is also expressed in mammary epithelia, thyroid follicular cells, yolk sacs, the ciliary body of the eye, the intestinal brush border, the male reproductive tract, uterus and oviduct, and gallbladder epithelium. In addition, immortalised foetal rat alveolar pretype II cells, adult rat type II pneumocytes and human type II cells have all been reported to express megalin. It has been proposed that in adult lung megalin may be important in supplying vitamin E to type II pneumocytes.
Specifically, Megalin mediates the uptake of apolipoprotein J, which is a binding protein for the beta-Amyloid peptide, a peptide implicated in Alzheimer's disease. It is also involved in renal uptake of Angiotensin and the reabsorption of various molecules including calcium, vitamin B12 and vitamin D.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LRP2 (4641-4655) antibody

Kidney Cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

LRP2 antibody

Predicted cell location: Cell membrane, Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using LRP2 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

LRP2 antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human esophagus and colon cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus and colon cancer tissue using LRP2 antibody at dilution 1/16, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

LRP2 antibody

Human Kidney carcinoma stained with LRP-2 Antibody Rabbit Purified Hu E, P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

LRP2 antibody

LRP2 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

LRP2 antibody

Staining (paraffin-embedded tissue-sections fixed in formalin) of Megalin in the brush border of the proximal tubule (Cat.-No DM3613P) Mouse IgG1 CD7D5 Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

LRP2 antibody

LRP2 Rabbit Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

LRP2 antibody

LRP2 Mouse IgG1 CD7D5 Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €490.00
  Novus Biologicals Inc.

LRP2 antibody

LRP2 Rabbit Hu E, P
50 µg / €480.00
  Novus Biologicals Inc.

LRP2 antibody

Immunohistochemistry-Paraffin: LRP2 Antibody [NBP1-85292] - Immunohistochemistry-Paraffin: LRP2 Antibody [NBP1-85292] Immunohistochemical staining of human kidney shows strong cytoplasmic membranous and extracellular positivity in cells in tubules Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

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