LRRC7 antibody

Principal name

LRRC7 antibody

Alternative names for LRRC7 antibody

LRRC7, KIAA1365, LAP1, Leucine-rich repeat-containing protein 7, Densin-180

SwissProt ID

P70587 (Rat), Q80TE7 (Mouse), Q96NW7 (Human)

Gene ID

117284 (Lrrc7), 57554 (LRRC7)

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of LRRC7 antibody

In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins.
The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B & 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A & B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.

General readings

This product has been used in:Yang L et al. Lamin-binding fragment of LAP2 inhibits increase in nuclear volume during the cell cycle and progression into S phase. J Cell Biol 139:1077-87 (1997). PubMed PMID: 9382857
Guan T et al. Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex. Mol Biol Cell 6:1591-603 (1995). PubMed PMID: 8589458
Martin L et al. cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane. J Biol Chem 270:8822-8 (1995). PubMed PMID: 7721789
Foisner R & Gerace L Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell 73:1267-79 (1993). PubMed PMID: 8324822
Senior A & Gerace L Integral membrane proteins specific to the inner nuclear membrane and associated with the nuclear lamina. J Cell Biol 107:2029-36 (1988). PubMed PMID: 3058715

7 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LRRC7 (N-term) antibody

Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

LRRC7 antibody

LRRC7 Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

LRRC7 antibody

LRRC7 Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

LRRC7 antibody

LRRC7 Mouse IgG1 RL13 Purified Rt ICC/IF, IP, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

LRRC7 antibody

LRRC7 Rabbit Purified Hu, Ms P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

LRRC7 antibody

Immunohistochemistry-Paraffin: LRRC7 Antibody [NBP1-90593] Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside reaction centra. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

LRRC7 antibody

Immunohistochemistry-Paraffin: LRRC7 Antibody [NBP1-90594] Immunohistochemical staining of human tonsil shows moderate cytoplasmic positivity in lymphoid cells outside reaction centra. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

7 Item(s)

per page
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