LRWD1 antibody

Principal name

LRWD1 antibody

Alternative names for LRWD1 antibody

ORC-associated protein, ORCA, Leucine-rich repeat and WD repeat-containing protein 1, Origin recognition complex-associated protein

SwissProt ID

Q6GM71 (Xenla), Q8BUI3 (Mouse), Q9UFC0 (Human)

Gene ID

222229 (LRWD1), 71735 (Lrwd1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat), Ye (Yeast)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of LRWD1 antibody

LRWD1 (UniProtKB/Swiss-Prot entry Q9UFC0) is a component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. LRWD1 is probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. It binds histone repressive methylation repressive marks on heterochromatin H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with D methylation. It is unclear whether it recognizes and binds these repressive marks by itself or needs additiol factors.

General readings

Teng, Y.N., et al. Int. J. Androl. 33(6):832-840(2010)
Shen, Z., et al. Mol. Cell 40(1):99-111(2010)
Vermeulen, M., et al. Cell 142(6):967-980(2010)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

6 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LRWD1 antibody

Host: Rabbit; Target Name: LOC304396; Sample Tissue: Rat Kidney lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

LRWD1 antibody

Determination of the antibody titer To determine the titer of the antibody, an ELISA was performed using a serial dilution of the antibody against human LRWD1. The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 1), the titer of the antibody was estimated to be 1:24,900. Rabbit IgG Purified Hu E
0.1 ml / €325.00
  OriGene Technologies, Inc.

LRWD1 (N-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue reacted with LRWD1 Antibody (N-term) Cat.-No AP52552PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

LRWD1 antibody

LRWD1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LRWD1

LRWD1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

LRWD1 overexpression lysate

LRWD1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

6 Item(s)

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