LSP1 / WP34 antibody

Principal name

LSP1 / WP34 antibody

Alternative names for LSP1 / WP34 antibody

Lymphocyte-specific protein 1, Protein pp52, 52 kDa phosphoprotein, Lymphocyte-specific antigen WP34, 47 kDa actin-binding protein

SwissProt ID

P19973 (Mouse), P33241 (Human), Q8CD28 (Mouse)

Gene ID

4046 (LSP1), 16985 (Lsp1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of LSP1 / WP34 antibody

Leukocyte-specific protein 1 (LSP1), is a calcium-dependent F-actin binding protein and a major downstream substrate of p38 mitogen-activated protein kinase as well as protein kinase C.  LSP1 plays an important role in leukocyte chemotaxis.  During T cell maturation, expression of LSP1 is low on immature CD4+CD8+ double positive thymocytes, but is highly expressed on mature single positive CD4 and CD8 T cells.
Distribution: Localized to the cytoplasmic leaflet of the plasma membrane.
Function: Contributes to lymphocyte and neutrophil activation and chemotaxis, as well as lymphocyte differentiation.
Regulation: Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2.
Modification: Phosphorylation.
Interaction: F-actin, Casein kinase II, PKC, MAPKAPK2.

General readings

Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Geijtenbeek TB,
Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.
Nature immunology 2009 Oct 10 (10): 1081-8.
PMID: 19718030

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LSP1 / WP34 antibody

  Rabbit Polyclonal LSP1 Antibody  
Immunohistochemistry: LSP1 Antibody - Immunohistochemical staining for lymphocyte-specific protein 1 (LSP1) in human lymphoidal  tissues.  Lymphoid tissues of lymph nodes displayed moderate to strong cytoplasmic positivity.  Normal epithelial and stromal cells were negative.  Most malignant lymphomas and a few cases of urothelial cancers expressed moderate cytoplasmic immunoreactivity (images not shown).  These image are the courtesy of the Human Proteome Resource (HPR). Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 (261-275) antibody

Antibody (AP23727PU-N)(1µg/ml) staining of Peripheral Blood Lymphocytes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

LSP1 / WP34 (C-term) antibody

  Goat Anti-LSP1 Antibody  
(0.05ug/ml) staining of Human Liver lysate (Lane 1), Mouse Liver lysate (Lane 2) and Rat Liver lysate (Lane 3) (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

  Rabbit polyclonal anti-LSP1 antibody  
Western blot analysis of extracts from HuvEc cells and K562 cells, using LSP1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

  Rabbit Polyclonal Anti-LSP1 Antibody  
WB Suggested Anti-LSP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: OVCAR-3 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

  Rabbit anti-LSP1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using LSP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

  Mouse monoclonal Anti-LSP1 Clone TPD153  
LSP1 / WP34 Mouse IgG1 TPD153 Purified Hu IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 (37-48) antibody

Thymus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µl / €530.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

LSP1 - human gene knockout kit via CRISPR

LSP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

LSP1 - human gene knockout kit via CRISPR

LSP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

LSP1 - human gene knockout kit via CRISPR

LSP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

LSP1 - human gene knockout kit via CRISPR

LSP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lsp1 - mouse gene knockout kit via CRISPR

Lsp1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Lsp1 - mouse gene knockout kit via CRISPR

Lsp1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lsp1 - mouse gene knockout kit via CRISPR

Lsp1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lsp1 - mouse gene knockout kit via CRISPR

Lsp1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LSP1 / WP34 (transcript variant 1)

  Recombinant protein of human lymphocyte-specific protein 1 (LSP1), transcript variant 1  
LSP1 / WP34 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

LSP1 overexpression lysate

LSP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, LSP1 (mGFP-tagged) - Human lymphocyte-specific protein 1 (LSP1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, LSP1 (mGFP-tagged) - Human lymphocyte-specific protein 1 (LSP1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, LSP1 (mGFP-tagged)-Human lymphocyte-specific protein 1 (LSP1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, LSP1 (mGFP-tagged)-Human lymphocyte-specific protein 1 (LSP1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

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