LSP1 / WP34 antibody

Principal name

LSP1 / WP34 antibody

Alternative names for LSP1 / WP34 antibody

Lymphocyte-specific protein 1, Protein pp52, 52 kDa phosphoprotein, Lymphocyte-specific antigen WP34, 47 kDa actin-binding protein

SwissProt ID

P19973 (Mouse), P33241 (Human), Q8CD28 (Mouse)

Gene ID

4046 (LSP1), 4314046 (IPR001926)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of LSP1 / WP34 antibody

Leukocyte-specific protein 1 (LSP1), is a calcium-dependent F-actin binding protein and a major downstream substrate of p38 mitogen-activated protein kinase as well as protein kinase C.  LSP1 plays an important role in leukocyte chemotaxis.  During T cell maturation, expression of LSP1 is low on immature CD4+CD8+ double positive thymocytes, but is highly expressed on mature single positive CD4 and CD8 T cells.
Distribution: Localized to the cytoplasmic leaflet of the plasma membrane.
Function: Contributes to lymphocyte and neutrophil activation and chemotaxis, as well as lymphocyte differentiation.
Regulation: Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2.
Modification: Phosphorylation.
Interaction: F-actin, Casein kinase II, PKC, MAPKAPK2.

General readings

J Exp Med. 2005 Feb 7;201(3):409-18. Epub 2005 Jan 31.
LSP1 is an endothelial gatekeeper of leukocyte transendothelial migration.
Liu L, Cara DC, Kaur J, Raharjo E, Mullaly SC, Jongstra-Bilen J, Jongstra J, Kubes P.
Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LSP1 / WP34 antibody

Immunohistochemistry: LSP1 Antibody - Immunohistochemical staining for lymphocyte-specific protein 1 (LSP1) in human lymphoidal  tissues.  Lymphoid tissues of lymph nodes displayed moderate to strong cytoplasmic positivity.  Normal epithelial and stromal cells were negative.  Most malignant lymphomas and a few cases of urothelial cancers expressed moderate cytoplasmic immunoreactivity (images not shown).  These image are the courtesy of the Human Proteome Resource (HPR). Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

Immunohistochemistry: LSP1 Antibody [24780002] - Lymphoid tissues displayed moderate to strong cytoplasmic positivity. Normal epithelial and stromal cells were negative. Among malignant cells, most malignant lymphomas and a few cases of urothelial cancers expressed moderate cytoplasmic immunoreactivity.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit Hu E, P, WB
50 µg / €440.00
  Novus Biologicals Inc.

LSP1 / WP34 (261-275) antibody

Antibody (AP23727PU-N)(1µg/ml) staining of Peripheral Blood Lymphocytes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

LSP1 / WP34 (C-term) antibody

(0.05ug/ml) staining of Human Liver lysate (Lane 1), Mouse Liver lysate (Lane 2) and Rat Liver lysate (Lane 3) (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

Western blot analysis of extracts from HuvEc cells and K562 cells, using LSP1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

WB Suggested Anti-LSP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: OVCAR-3 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

Western blot analysis of extracts of various cell lines, using LSP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

LSP1 / WP34 antibody

Cell extracts from THP-1 cells were western blotted with anti-LSP1 Antibody Cat.-No AM33059PU-N (Clone 5E3). Mouse IgG1 5E3 Purified Hu ICC/IF, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

LSP1 / WP34 antibody

Cell extracts from THP-1 cells were western blotted with anti-LSP1 Antibody Cat.-No AM33059PU-N (Clone 5E3). Mouse IgG1 5E3 Purified Hu ICC/IF, WB
25 µg / €230.00
  Acris Antibodies GmbH

LSP1 / WP34 (37-48) antibody

Thymus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

LSP1 / WP34 antibody

Western Blot analysis of LSP1 expression in transfected 293T cell line (H00004046-T01) by LSP1 MaxPab polyclonal antibody.

Lane 1: LSP1 transfected lysate(37.29 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

LSP1 / WP34 antibody

Immunoprecipitation of LSP1 transfected lysate using anti-LSP1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with LSP1 MaxPab mouse polyclonal antibody (B01) (H00004046-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

LSP1 / WP34 antibody

Western Blot analysis of LSP1 expression in transfected 293T cell line (H00004046-T01) by LSP1 MaxPab polyclonal antibody.

Lane 1: LSP1 transfected lysate(37.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

LSP1 / WP34 antibody

Western Blot analysis of LSP1 expression in transfected 293T cell line by LSP1 monoclonal antibody (M07), clone 1C4.

Lane 1: LSP1 transfected lysate(37.2 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1C4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

LSP1 / WP34 pSer204 antibody

LSP1 / WP34 Mouse IgG1 AT-1E6 Hu, Ms, Rt E, WB
0.1 mg / €510.00
  Abnova Taiwan Corp.

LSP1 / WP34 pSer252 antibody

The whole cell lysate derived from m-CSF stimulated Jurket cells ( lane 1 ) or mouse spleen ( Lane 2 ) were immune-probed by LSP1 ( phospho S252 ) polyclonal antibody ( Cat # PAB12633 ) at 1 : 500. An immunoreactive band is observed around ~ 52kDa. Rabbit Hu, Ms C, E, IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

LSP1 / WP34 antibody

The tissue lysate derived mouse spleen was immune-probed by LSP1 polyclonal antibody ( Cat # PAB12702 ) at 1 : 500. An immunoreactive band is observed around ~52kDa. Rabbit Hu, Ms C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

LSP1 / WP34 antibody

Human OVCAR-3; WB Suggested Anti-LSP1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: OVCAR-3 cell lysate; LSP1 antibody - N-terminal region (AVARP00014_P050) in Human OVCAR-3 cells using Western Blot Rabbit Aff - Purified Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

LSP1 / WP34 antibody

LSP1 / WP34 Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

LSP1 / WP34 antibody

LSP1 / WP34 Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

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