LST8 / GBL antibody

Principal name

LST8 / GBL antibody

Alternative names for LST8 / GBL antibody

TORC subunit LST8, mLST8, Protein GbetaL, Gable, Target of rapamycin complex subunit LST8, Mammalian lethal with SEC13 protein 8, G protein beta subunit-like

SwissProt ID

Q17QU5 (Bovin), Q5I0B4 (Xentr), Q9BVC4 (Human), Q9DCJ1 (Mouse), Q9Z2K5 (Rat)

Gene ID

64223 (MLST8), 56716 (Mlst8), 64226

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chimp (Chimpanzee), Chk (Chicken), Mky (Monkey), Can (Canine), Macaque

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of LST8 / GBL antibody

GbetaL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors (1). It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 2). Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 3). TOR is normally associated with GβL and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis (3). The binding of GβL to TOR stimulates TOR’s kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth (3).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LST8 / GBL antibody

  Rabbit Polyclonal Antibody against GBL (Center)  
Western blot analysis of GBL Antibody (Center) polyclonal antibody(Cat.#TA302160)(arrow). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GBL gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LST8 / GBL antibody

  Rabbit Polyclonal GBL Antibody  
Western blot analysis of GbL in human brain cell lysate with GbL antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LST8 / GBL antibody

  Anti-MLST8 Rabbit Polyclonal Antibody  
Predicted band size: 36 kDa . Positive control: Testis tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LST8 / GBL antibody

  MLST8 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using MLST8 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

LST8 / GBL antibody

  Rabbit Polyclonal Anti-GBL Antibody - middle region  
WB Suggested Anti-GBL Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

LST8 / GBL antibody

Figure 2. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, Cortex. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

LST8 / GBL (150-200) antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Purified Bov, Can, Chk, Hu, Macaque, Mky, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MLST8 - human gene knockout kit via CRISPR

MLST8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MLST8 - human gene knockout kit via CRISPR

MLST8 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MLST8 - human gene knockout kit via CRISPR

MLST8 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MLST8 - human gene knockout kit via CRISPR

MLST8 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mlst8 - mouse gene knockout kit via CRISPR

Mlst8 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mlst8 - mouse gene knockout kit via CRISPR

Mlst8 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mlst8 - mouse gene knockout kit via CRISPR

Mlst8 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mlst8 - mouse gene knockout kit via CRISPR

Mlst8 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MLST8 overexpression lysate

MLST8 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

MLST8-knockout Cell lysate

MLST8-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mlst8 (GFP-tagged ORF) - Rat G protein beta subunit-like (Gbl), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mlst8 (GFP-tagged ORF) - Rat G protein beta subunit-like (Gbl), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Mlst8 (Myc-DDK-tagged ORF) - Rat G protein beta subunit-like (Gbl), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mlst8 (Myc-DDK-tagged ORF) - Rat G protein beta subunit-like (Gbl), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

19 Item(s)

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