Luteinizing hormone beta (LSH-beta) antibody

Principal name

Luteinizing hormone beta (LSH-beta) antibody

Alternative names for Luteinizing hormone beta (LSH-beta) antibody

LHB, LH-B, LSH-beta, Luteinizing hormone subunit beta, Lutropin beta chain, Lutropin subunit beta

SwissProt ID

O09108 (Mouse), O77805 (Felca), P01229 (Human), P01230 (Rat), P01231 (Sheep), P01232 (Pig), P04651 (Bovin), P18842 (Canfa), Q6IY74 (Rabit)

Gene ID

3972 (LHB), 25329 (Lhb), 397153

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Bov (Bovine), Deer, Gt (Goat), Sh (Sheep), Mky (Monkey), Rt (Rat), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat, Sheep

Available applications

Radioimmunoassay (R), Paraffin Sections (P), Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (capture) (E(capture)), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Dot blot (Dot)

Background of Luteinizing hormone beta (LSH-beta) antibody

The pituitary hormones, luteinizing hormone (lutropin, LH) and follicle stimulating hormone (follitropin, FSH) as well as related placental hormones, chorionic gonadotropin and CG, are referred to as gonadotropic hormones because of their action on gonad cells. These three hormones are structurally related to each other as well as to thyroid stimulating hormone (TSH). Because of their similar structure and composition and glycoprotein nature, LH, TSH, GC and FSH, these hormones are referred to as glycoprotein hormones. All these hormones are heterodimeric in nature composed of two un-identical subunits, alpha and beta which are non-covalently associated, Among humans and other species, the Alpha subunit is identical for all these hormones and is coded by a single gene, where is beta subunits are distinct but homologous and arise from separate genes. The individual hormone subunits and peptides derived from them have shown some binding activities to their respective receptors, the association of alpha and beta subunits clearly is required for optimal activation and physiological responses elicited by these hormones. Within the heterodimeric hormones, the beta subunit confors the binding activity to its respective receptor. The LH and CG beta subunits have 85% sequence identity in their first 114 amino acids, the LH/CG receptors can recognize either of the pituitary LH or placental CG hormones.
The alpha and beta subunits of LH, CG and FSH are highly glycosylated (1). The alpha subunit has two N-linked oligosdaccharide chain at position 52 and 78 and beta subunits have one in LH and TSH and two in CG and FSH. The CG beta subunit also has an extension of serine O-linked carbohydrates at carboxyl end which help is plasma half like of CG compared to other glycohormone beta subunits. The N-linked oligosaccharides on FSH are sialylated whereas LH and TSH are sialylated and sulfated. There are 10-12 cysteins forming 3 disulfide bonds referred to as “cystine knots” in each of the beta subunits of these hormones which are conserved in various species. Adenohypophyseal gonadotroph cells synthesize and secrete LH and FSH under independent regulatory controls and their release by pituitary is positively regulated by hypothalamic decapeptide gonadotropin releasing hormone (GnRH) and is negatively regulated by feedback effects of gonadal steroids and gonadal, peptide inhibin, a peptide produced in testis and ovaries in response to FSH (2). Both males and females synthesize and secrete FSH and LH by gonadotrope cells of the anterior pituitary. In females progesterone and estrogen inhibit LH and FSH release. The action of LH and CG are carried out by LH/CG receptors and FSH effects are by independent FSH receptors with GPCR associated 7TMDs.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Luteinizing Hormone (LH) antibody

Human pituitary stained with anti-LH antibody Rabbit IgG SP132 Purified Hu, Mky P
0.5 ml / €510.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Human pituitary stained with anti-LH antibody Rabbit IgG SP132 Purified Hu, Mky P
1 ml / €730.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Human pituitary stained with anti-LH antibody Rabbit IgG SP132 Purified Hu, Mky P
0.1 ml / €290.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Mouse IgG1 090-11412 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Mouse IgG1 090-10226 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Mouse IgG1 057-10037 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Mouse IgG2a 057-10036 Purified Hu E
1 mg / €330.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Rabbit Purified Can C, WB
50 µl / €540.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Rabbit Serum Hu R
0.1 ml / €380.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Rabbit Serum Hu R
20 µl / €150.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Rabbit Serum Bov, Deer, Gt, Hu, Sh C, E, R, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Rabbit Serum Bov, Deer, Gt, Hu, Sh C, E, R, WB
20 µl / €150.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Sheep IgG Purified Hu
0.25 ml / €300.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Rabbit IgG Purified Por C, WB
50 µl / €520.00
  Acris Antibodies GmbH

Luteinizing Hormone (LH) antibody

Luteinizing Hormone (LH) Mouse IgG1 5A5 Ig Fraction Hu R
1 mg / €440.00
  Acris Antibodies GmbH

Luteinizing hormone (LH) antibody

Luteinizing hormone (LH) Mouse IgG1 3A8 Hu E
0.1 mg / €410.00
  Abnova Taiwan Corp.

Luteinizing hormone (LH) antibody

Luteinizing hormone (LH) Mouse IgG1 1E8 Hu E
0.1 mg / €410.00
  Abnova Taiwan Corp.

Luteinizing hormone (LH) antibody

Luteinizing hormone (LH) Mouse IgG1 1A2 Hu E
0.1 mg / €410.00
  Abnova Taiwan Corp.

Luteinizing hormone (LH) antibody

Luteinizing hormone (LH) Mouse IgG1 I/4A11 Hu E, R
1 mg / €640.00
  Abnova Taiwan Corp.

Luteinizing hormone (LH) antibody

Luteinizing hormone (LH) Mouse 1/2D7 1D9 Hu E, R
1 mg / €820.00
  Abnova Taiwan Corp.

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