Ly6A/E / SCA1 antibody

Principal name

Ly6A/E / SCA1 antibody

Alternative names for Ly6A/E / SCA1 antibody

Lymphocyte antigen 6A-2/6E-1, Ly-6A.2/Ly-6E.1, T-cell-activating protein, TAP, Stem cell antigen 1, SCA-1

SwissProt ID

P05533 (Mouse), Q63316 (Rat)

Gene ID

110454 (Ly6a)

Available reactivities

Ms (Mouse)

Available hosts

Mouse, Rat, Rabbit

Available applications

Cytotoxicity Assay (CT), Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Ly6A/E / SCA1 antibody

Sca-1 is a member of the Ly-6 antigen family with molecular mass of 8 kDa under non-reducing conditions and 18 kDa under reducing conditions. Mouse hematopoietic stem cells express low levels of Thy-1 antigen (Thy-1lo) and to be negative for lineage markers (Lin-) that is, not expressing markers characteristic of B cells (B220), granulocytes (Gr-1), myelomonocytic cells (Mac-1) and T lymphocytes (CD4 and CD8). Recently, a new monoclonal antibody, anti-Sca-1, was used to purify stem cells from the Thy-1lo, Lin- bone marrow subpopulation. Thy-1lo, Lin-, Sca-1+ (but not the Thy-1lo, Lin-, Sca-1-) population of bone marrow cells are highly purified pluripotent stem cells. They read out with nearly unit efficiency in assays for primitive myeloerythroid and thymic progenitor, and have a capability to admit lethally irradiated mouse to survive and be restored in all blood-cell lineages. The Thy-1lo, Lin-, Sca-1+ subpopulation thought to have all stem cells present in the bone marrow.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ly6A/E / SCA1 antibody

Flow cytometric analysis of Biotin labeled mouse S ca-1 expression on LO cells. Open histogram indicates the reaction of Isotypic control to the cells. Shaded histogram indicates the reaction of AM26430BT-N to the cells. Rat IgG2a 238B Biotin Ms F
0.1 ml / €340.00
  OriGene Technologies GmbH

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