LY86 / MD-1 antibody

Principal name

LY86 / MD-1 antibody

Alternative names for LY86 / MD-1 antibody

Lymphocyte antigen 86, MD1

SwissProt ID

O88188 (Mouse), O95711 (Human), Q90890 (Chick)

Gene ID

9450 (LY86), 17084 (Ly86)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), ELISA (detection) (E(detection)), Functional assay (FN), Frozen Sections (C)

Background of LY86 / MD-1 antibody

Mammalian MD1 is a homolog of Chicken MD1, which was previously isolated as a v-myb-regulated gene, since its transcription increases rapidly after v-myb induction. MD1 is a 28 kDa molecule that is associated at the cell surface with RP105 (CD180). RP105 is a leucine-rich repeat (LRR) molecule that is expressed on B lymphocytes. It was first identified by a mAb that protects spleen B cells from irradiation-induced apoptosis. LRR proteins, such as Toll receptors, have a role in innate immunity. MD1 is primarily expressed by B cells, dendritic cells and monocytes, and promotes the recognition of, and subsequent signaling by LPS in the innate immune system. MD1 does not have any homology to other molecules. MD1 when expressed alone behaves as a secretory protein. Expression of MD1 in a cell increases the expression of RP105.

General readings

1. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335 - 76.
2. Divanovic S, Trompette A, Atabani SF, et al. Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. J. Endotoxin Res. 2005; 11:363 - 8.
3. Tsuneyoshi N, Fukudome K, Kohara J, et al. The functional and structural properties of MD-2 required for liposaccharide binding are absent in MD-1. J. Immunol. 2005; 174:340 - 4.
4. Nagai Y, Kobayashi T, Motoi Y, et al. The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes. J. Immunol. 2005; 174:7043 - 9.
5. UniProtKB/Swiss-Prot entry O95711, http://www.expasy.org/uniprot/O95711, accessed January
29, 2007

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LY86 / MD-1 (C-term) antibody

Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LY86 / MD-1 (Center) antibody

Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LY86 / MD-1 antibody

LY86 / MD-1 Rat IgG2b MD113 Biotin Ms F
50 µg / €280.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

LY86 / MD-1 Rat IgG2b MD113 FITC Ms F
0.1 mg / €390.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

LY86 / MD-1 Rat IgG2b MD113 Purified Ms F
0.25 mg / €520.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

LY86 / MD-1 Rat IgG2b MD113 Purified Ms F, FN
0.1 mg / €340.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 0.5, (B) 1 and (C) 2 µg/ml. Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

Figure 1. Staining MD1 in Spleen by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

LY86 / MD-1 Control Peptide

LY86 / MD-1
50 µg / €160.00
  Acris Antibodies GmbH

LY86 / MD-1 Control Peptide

LY86 / MD-1
50 µg / €160.00
  Acris Antibodies GmbH

LY86 / MD-1 (C-term) antibody

Western blot analysis of LY86 / MD-1 Antibody (C-term) Cat.-No AP52566PU-N in mouse bladder tissue lysates (35ug/lane). This demonstrates the LY86 antibody detected the LY86 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

LY86 / MD-1 antibody

Immunoperoxidase of purified MaxPab antibody to LY86 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml] Mouse Purified Hu E(detection), P, WB
50 µg / €370.00
  Abnova Taiwan Corp.

LY86 / MD-1 antibody

Detection limit for recombinant GST tagged LY86 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 1H3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

LY86 / MD-1 antibody

Western blot analysis of LY86 in cell lysates from Ramos using LY86 polyclonal antibody ( Cat # PAB0185 ) at 2 µg/ml dilution. Rabbit Hu, Ms IP, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

LY86 / MD-1 antibody

Western blot analysis of LY86 in Daudi cell lysate with LY86 polyclonal antibody ( Cat # PAB10119 ) at 2 µg/ml. Hu, Ms, Rt
0.1 mg / €470.00
  Abnova Taiwan Corp.

LY86 / MD-1 antibody

Western blot analysis of LY86 in Daudi cell lysate with LY86 polyclonal antibody ( Cat # PAB10120 ) at 2 µg/ml. Hu
0.1 mg / €470.00
  Abnova Taiwan Corp.

LY86 / MD-1 antibody

Western Blot: MD-1 Antibody [NB100-56700] - Western blot analysis of MD-1 in cell lysates from Ramos using NB100-56700 at 2 ug/ml dilution. Rabbit IgG Aff - Purified Hu, Ms IP, WB
0.1 mg / €320.00
  Novus Biologicals Inc.

LY86 / MD-1 antibody

C57BL/6 mouse splenocytes stained with purified MD-14, followed by anti-rat IgG FITC Rat IgG2a MD-14 Aff - Purified Ms F
50 µg / €360.00
  Novus Biologicals Inc.

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