LYN antibody

Principal name

LYN antibody

Alternative names for LYN antibody

Tyrosine-protein kinase Lyn

SwissProt ID

P07948 (Human), P25911 (Mouse), Q07014 (Rat)

Gene ID

4067 (LYN), 17096 (Lyn), 81515

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Sh (Sheep), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of LYN antibody

Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.

Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

General readings

1. Kim S & Kunapuli SP Negative Regulation of Gq-mediated Pathways in Platelets by G12/13 Pathways through Fyn Kinase. J Biol Chem 286:24170-9 (2011). WB ; Human .PubMed: 21592972
2. Gross AJ  et al. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol 182:5382-92 (2009). WB ; Mouse .PubMed: 19380785

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LYN antibody

Western Blotting analysis (non-reducing conditions) of Lyn using anti-Lyn (LYN-01). Lane 1: negative control. Lane 2: RBL rat basophilic leukemia cell line. Lane 3: JURKAT human peripheral blood T cell leukemia cell line. Lane 4: A-431 human epidermoid carcinoma cell line. Lane 5: U-937 human histiocytic lymphoma cell line. Mouse IgG1 LYN-01 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

LYN antibody

  Rabbit Polyclonal Anti-LYN Antibody  
Host: Rabbit; Target Name: LYN; Sample Tissue: Human Fetal Brain; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

LYN antibody

  Goat Polyclonal Antibody against LYN  
TA303350 (0.1µg/ml) staining of U937 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LYN (N-term) antibody

  Rabbit polyclonal LYN Antibody (N-term)  
Western blot analysis of anti-LYN Antibody (N-term) (Cat.#TA324977) in HL60 cell line lysates (35ug/lane). LYN (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

LYN antibody

  Rabbit Polyclonal Lyn Antibody  
Western blot analysis of Lyn expression in H2O2 treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYN antibody

  Rabbit Polyclonal Lyn (Tyr507) Antibody (Phospho-specific)  
Western blot analysis of Lyn phosphorylation expression in H2O2 treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYN antibody

  Rabbit Polyclonal Anti-LYN Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (LYN Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYN antibody

  Rabbit Polyclonal Lyn Antibody  
ELISA: Lyn Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

LYN antibody

Western blot analysis using LYN antibody Cat.-No AM06164SU-N agains HL60 (Lane 1), L540 (Lane 2), SLLP-M2 (Lane 3), SEM (Lane 4) and Ramos (Lane 5) cell lysate. Mouse IgG2b 2H8D7 Ascites Hu WB
0.1 ml / €440.00
  Acris Antibodies GmbH

LYN antibody

Immunohistochemistry (IHC) analyzes of Lyn antibody (Cat.-No.: AP06399PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

LYN pTyr507 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Lyn (Phospho-Tyr507) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

LYN pTyr507 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Lyn (Phospho-Tyr507) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

LYN antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Lyn (Ab-507) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

LYN antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Lyn (Ab-507) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Lyn - mouse gene knockout kit via CRISPR

Lyn - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Lyn - mouse gene knockout kit via CRISPR

Lyn - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lyn - mouse gene knockout kit via CRISPR

Lyn - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lyn - mouse gene knockout kit via CRISPR

Lyn - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

LYN (transcript variant 2)

  Purified recombinant protein of Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (LYN), transcript variant 2  
LYN Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

LYN (1-512, His-tag)

LYN Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

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