LYN antibody

Principal name

LYN antibody

Alternative names for LYN antibody

Tyrosine-protein kinase Lyn

SwissProt ID

P07948 (Human), P25911 (Mouse), Q07014 (Rat)

Gene ID

4067 (LYN)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Sh (Sheep), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of LYN antibody

Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.

Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

General readings

This product has been used in:Kovarova M et al. Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation. Mol Cell Biol 21:8318-28 (2001). PubMed PMID: 11713268
Amoui M et al. Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors. Eur J Immunol 27:321-8 (1997). PubMed PMID: 9022035
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LYN antibody

Western Blotting analysis (non-reducing conditions) of Lyn using anti-Lyn (LYN-01). Lane 1: negative control. Lane 2: RBL rat basophilic leukemia cell line. Lane 3: JURKAT human peripheral blood T cell leukemia cell line. Lane 4: A-431 human epidermoid carcinoma cell line. Lane 5: U-937 human histiocytic lymphoma cell line. Mouse IgG1 LYN-01 Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

LYN antibody

Host: Rabbit; Target Name: LYN; Sample Tissue: Human Fetal Brain; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

LYN antibody

TA303350 (0.1µg/ml) staining of U937 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, WB
20 µg / €200.00
  Acris Antibodies GmbH

LYN antibody

TA303350 (0.1µg/ml) staining of U937 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LYN (N-term) antibody

Western blot analysis of anti-LYN Antibody (N-term) (Cat.#TA324977) in HL60 cell line lysates (35ug/lane). LYN (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

LYN antibody

Western blot analysis of Lyn expression in H2O2 treated K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYN antibody

ELISA: Lyn Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

LYN antibody

Western blot analysis using LYN antibody Cat.-No AM06164SU-N agains HL60 (Lane 1), L540 (Lane 2), SLLP-M2 (Lane 3), SEM (Lane 4) and Ramos (Lane 5) cell lysate. Mouse IgG2b 2H8D7 Ascites Hu WB
0.1 ml / €440.00
  Acris Antibodies GmbH

LYN antibody

Immunohistochemistry (IHC) analyzes of Lyn antibody (Cat.-No.: AP06399PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

LYN antibody

Immunofluorescence of purified MaxPab antibody to LYN on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

LYN antibody

LYN Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

LYN antibody

LYN Rabbit Serum Hu, Ms E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

LYN antibody

LYN MaxPab rabbit polyclonal antibody. Western Blot analysis of LYN expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

LYN antibody

Western blotting analysis ( non - reducing conditions ) of LYN using LYN monoclonal antibody, clone LYN - 01 ( Cat # MAB0949 ) . Lane 1 : Negative control. Lane 2 : RBL rat basophilic leukemia cell line. Lane 3 : Jurkat human peripheral blood T cell leukemia cell line. Lane 4 : A - 431 human epidermoid carcinoma cell line. Lane 5 : U - 937 human histiocytic lymphoma cell line. Mouse IgG1 LYN-01 Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

LYN antibody

LYN Mouse IgG2a 11A7 Hu, Ms, Rt IP, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

LYN antibody

Western blot analysis using LYN monoclonal antibody, clone 2H8D7 ( Cat # MAB5531 ) against truncated LYN recombinant protein ( Lane 1 ), HL-60 cell lysate ( Lane 2 ). Mouse IgG2b 2H8D7 Hu E, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

LYN antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with LYN polyclonal antibody ( Cat # PAB3431 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

LYN antibody

LYN polyclonal antibody ( Cat # PAB7459 ) ( 0.1 µg/ml ) staining of U-937 lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

LYN pTyr507 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Lyn (Phospho-Tyr507) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

LYN pTyr507 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Lyn (Phospho-Tyr507) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

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