Lysyl oxidase antibody

Principal name

Lysyl oxidase antibody

Alternative names for Lysyl oxidase antibody

LOX, Protein-lysine 6-oxidase, EC=1.4.3.13

SwissProt ID

P16636 (Rat), P28300 (Human), P28301 (Mouse), P33072 (Bovin), P45845 (Pig), Q05063 (Chick)

Gene ID

4015 (LOX), 24914 (Lox), 16948

Available reactivities

Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Xen (Xenopus), Ze (Zebrafish), Mky (Monkey), Can (Canine), Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F), Luminex (LMNX)

Background of Lysyl oxidase antibody

LOX (lysyl oxidase) is a copper-dependent amine oxidase enzyme responsible for post-translatiol oxidative deamition of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOX is synthesized as an ictive 50 kD proenzyme that is N-glycosylated in ER/Golgi complex and then secreted into extracellular environment, where it is processed by pro-collagen C-proteises (mammalian Tolloids and BMP-1) into an active enzyme (28-32 kD) and an 18 kD propeptide (LOX-PP) which can be N-glycosylated intracellularly into a ~35 kD form. LOX activity is critical in maintaining the tensile as well as elastic features of the connective tissues of skeletal, pulmory and cardiovascular systems. LOX deficiency leads to intra-gestatiol lethality in LOX-/- mice wherein the pups exhibits aortic aneurysms/tortuosity/rupture. LOX expression is highly regulated during normal development; and, its aberrant expression or activity has been documented in a range of diseases predomintly associated with the ECM such as Cutis laxa or OHS (occipital horn syndrome), Menkes' syndrome, myocardial ischaemia/heart failure, atherosclerosis, scleroderma, liver cirrhosis, Pseudoexfoliation syndrome and glaucoma, Alzheimer's/non-Alzheimer's dementia, Wilson's disease, primary biliary cirrhosis as well as in many type of cancers, wherein LOX implicates in promoting tumor cell invasion and metastasis.

General readings

Kim Y., et al. (1995) J. Biol. Chem. 270:7176-7182.Contente S., et al. (1999) Mol. Cell. Biochem. 194:79-91.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Lysyl oxidase antibody

Western Blot: LOX propeptide Antibody [TA336520] - Detection of LOPP in MC3T3-E1 cell lysate. Rabbit Purified Hu, Ms, Por, Prim, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500859) Mouse IgG1 OTI5C4 Purified Can, Hu, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Anti-LOX mouse monoclonal antibody (TA500860) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LOX(RC213323). Mouse IgG1 OTI3C3 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500863) Mouse IgG1 OTI9G2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500865) Mouse IgG1 OTI4E3 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500866) Mouse IgG1 OTI8G5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500868) Mouse IgG1 OTI6B11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500869) Mouse IgG1 OTI6B7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500870) Mouse IgG1 OTI10D11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500871) Mouse IgG1 OTI9G6 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-LOX mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500877) Mouse IgG1 OTI9A11 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Lysyl oxidase antibody

LOX ELISA with 3C3 Capture (TA600029) and 9A11 Detection (TA700029) Antibodies. Substrate used: Recombinant Human LOX (TP313323) Mouse IgG1 OTI9A11 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Detection of LOX in human kidney lysate Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Detection of LOX protein, Lane 1: Twice extracted guanidine hydrochloride mouse tibia/fibula lysate., Lane 2: normal rabbit serum Rabbit IgG Purified Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Detection of LOX in mouse kidney lysate, ECL detection was 15 sec Rabbit IgG Purified Bov, Hu, Ms, Por, Rt C, WB
50 µl / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Predicted band size: 47 kDa. Positive control: Mouse liver tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 60 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Predicted cell location: Cytoplasm . Positive control: Human breast and colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using LOX antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Predicted band size: 47kDa. Positive control: 293T cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 60 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Predicted band size: 47 kDa. Positive control: Human leiomyosarcoma tissue. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 60 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysyl oxidase antibody

Western Blot: LOX Antibody [TA336290] - Analysis of LOX in human kidney Rabbit Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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