LYVE-1 antibody

Principal name

LYVE-1 antibody

Alternative names for LYVE-1 antibody

LYVE1, CRSBP-1, CRSBP1, HAR, XLKD1, Lymphatic vessel endothelial hyaluronic acid receptor 1, Cell surface retention sequence-binding protein 1, Hyaluronic acid receptor, Extracellular link domain-containing protein 1

SwissProt ID

Q6UC88 (Bovin), Q8BHC0 (Mouse), Q9Y5Y7 (Human)

Gene ID

10894 (LYVE1), 114332 (Lyve1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Flow Cytometry (F), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection))

Background of LYVE-1 antibody

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, and podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

General readings

General / background references:Jackson DG The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. Trends Cardiovasc Med 13:1-7 (2003). PubMed PMID: 12554094
Carriera et al Cancer Research 61:8079 (2001).Sleeman JP et al. Markers for the lymphatic endothelium: in search of the holy grail? Microsc Res Tech 55:61-9 (2001). PubMed PMID: 11596151
Makinen T et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J 20:4762-73 (2001). PubMed PMID: 11532940

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

LYVE-1 antibody

DP3500 LYVE-1 antibody staining of Human Spleen Paraffin section.
The experiment was performed by Prof. Dr. Birte Steiniger, Institute of Anatomy and Cell Biology Robert-Koch-Str. 8, D-35037 Marburg, Germany. Rabbit Purified Hu C, E, F, P, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

LYVE-1 antibody

LYVE-1 antibody staining of Human Intestine (border area of a Colon Carcinoma).
The experiment has been performed by Dr. Karsten Debel, DCS, Hamburg, Germany. Rabbit Aff - Purified Hu C, E, F, P, WB
50 µg / €280.00
  Acris Antibodies GmbH

LYVE-1 antibody

Figure 4. LYVE-1 and CD31 staining on frozen sections (5μm) of the Mouse prostate.The experiments were performed by Scott Gerber & Edith Lord, PhD, University of Rochester, USA. Rabbit Purified Ms C, E, F, ICC/IF, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

LYVE-1 antibody

Paraffin Section of Mouse Intestine stained with LYVE-1 Antibody Cat.-No DP3513P. You see the Staining (red) of lymphatic endothelial cells of the intestine. Rabbit IgG Aff - Purified Ms, Rt C, E, F, ICC/IF, P, WB
50 µg / €280.00
  Acris Antibodies GmbH

LYVE-1 antibody

DP3500 LYVE-1 antibody staining of Human Spleen Paraffin section.
The experiment was performed by Prof. Dr. Birte Steiniger, Institute of Anatomy and Cell Biology Robert-Koch-Str. 8, D-35037 Marburg, Germany. Rabbit Purified Hu C, E, F, P, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

LYVE-1 antibody

Figure 4. LYVE-1 and CD31 staining on frozen sections (5μm) of the Mouse prostate.The experiments were performed by Scott Gerber & Edith Lord, PhD, University of Rochester, USA. Rabbit Purified Ms C, E, F, ICC/IF, WB

Regular Price: 0.1 mg / €270.00

Special Price: 0.1 mg / €202.50

  Acris Antibodies GmbH

LYVE-1 antibody

Western Blot: LYVE1 Antibody [TA336490] - Analysis of LYVE1 in human lymph node lysate. Rabbit Purified Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYVE-1 antibody

Immunohistochemistry-Paraffin: LYVE1 Antibody [NB600-1005] Rabbit IgG Purified Hu C, E, F, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

LYVE-1 antibody

Immunohistochemistry-Paraffin: LYVE1 Antibody [NB600-1008] - Human and mouse intestine with a polyclonal antibody directed against human LYVE-1  and mouse LYVE-1 . You see the staining (red) of lymaphatic endothelial cells of the intestine. _x000d_ Rabbit IgG Purified Ms, Rt C, E, F, ICC/IF, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

LYVE-1 antibody

Detection of LYVE-1 in recombinant human protein, ECL detection overnight Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYVE-1 antibody

Immunohistochemistry of cryosections of mouse intestine at 2.5 ug/ml of anti-mouse LYVE-1 antibody followed by Anti-Rat IgG Rhodamine (right). Phase image of same field (left). Rat ALY7 Purified Ms F, P
25 µg / €120.00
  OriGene Technologies, Inc.

LYVE-1 antibody

Predicted band size: 35kDa. Positive control: A549 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 30 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYVE-1 antibody

Predicted band size: 35 kDa . Positive control: Mouse liver tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 50 ug Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

LYVE-1 antibody

WB Suggested Anti-LYVE1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

LYVE-1 antibody

Western blot analysis of LYVE1 expression in MCF7 whole cell lysates, the lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LYVE-1 antibody

TA348956 (2 ug/ml) staining of Human Cerebellum (A) and Liver (B) lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

LYVE-1 (1-228) antibody

Immunohistochemical detection of Mouse LYVE-1 on paraffin embedded section of lymhatic vessel in Mouse intestine with AM26529AF-N.These paraffin sections were kindly provided by Dr. Tohru Morisada, M.D. Ph.D (The department of Cell Differentiation, The Sakaguchi Laboratory, Department of Obstetrics and Gynecology, School of Medicine, Keiro University, Tokyo) Rat IgG1 ALY7 Azide Free Ms F, P
0.1 mg / €360.00
  Acris Antibodies GmbH

LYVE-1 (N-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

LYVE-1 (C-term) antibody

Figure 2. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

LYVE-1 (271-275) antibody

Western blot analysis of extracts from MCF cells using Lymphatic vessel endothelial hyaluronic acid receptor 1 Antibody AP26047PU-N and the same antibody preincubated with blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Acris Antibodies GmbH

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