MACC1 antibody

Principal name

MACC1 antibody

Alternative names for MACC1 antibody

Metastasis-associated in colon cancer protein 1

SwissProt ID

Q6ZN28 (Human)

Gene ID

346389 (MACC1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)

Background of MACC1 antibody

Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MACC1 antibody

Western blot analysis of MACC1 in mouse liver tissue lysate with MACC1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MACC1 Control Peptide

MACC1
50 µg / €160.00
  Acris Antibodies GmbH

MACC1 antibody

Immunohistochemistry-Paraffin: MACC1 Antibody [NBP1-89351] Immunohistochemical staining of human colon shows strong positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

MACC1 antibody

Immunohistochemistry-Paraffin: MACC1 Antibody [NBP1-89352] - Immunohistochemical staining of human endometrium shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

MACC1 antibody

Immunohistochemistry-Paraffin: MACC1 Antibody [NBP1-89353] Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MACC1

MACC1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MACC1 overexpression lysate

MACC1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

7 Item(s)

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