MACC1 antibody

Principal name

MACC1 antibody

Alternative names for MACC1 antibody

Metastasis-associated in colon cancer protein 1

SwissProt ID

Q6ZN28 (Human)

Gene ID

346389 (MACC1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of MACC1 antibody

Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MACC1 antibody

  Rabbit Polyclonal MACC1 Antibody  
Western blot analysis of MACC1 in mouse liver tissue lysate with MACC1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MACC1 antibody

  Rabbit Polyclonal Anti-MACC1 rabbit polyclonal antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (MACC1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

MACC1 - human gene knockout kit via CRISPR

MACC1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MACC1 - human gene knockout kit via CRISPR

MACC1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MACC1 - human gene knockout kit via CRISPR

MACC1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MACC1 - human gene knockout kit via CRISPR

MACC1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MACC1

  Recombinant protein of human metastasis associated in colon cancer 1 (MACC1)  
MACC1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MACC1 overexpression lysate

MACC1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MACC1 (mGFP-tagged) - Human metastasis associated in colon cancer 1 (MACC1), 200 uL, >10^7 TU/mL

Lenti ORF particles, MACC1 (mGFP-tagged) - Human metastasis associated in colon cancer 1 (MACC1), 200 uL, >10^7 TU/mL  
200 µl / €1,810.00
  OriGene Technologies, Inc.

Lenti ORF particles, MACC1 (Myc-DDK tagged) - Human metastasis associated in colon cancer 1 (MACC1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, MACC1 (Myc-DDK tagged) - Human metastasis associated in colon cancer 1 (MACC1) , 200 uL, >10^7 TU/mL  
200 µl / €1,630.00
  OriGene Technologies, Inc.

10 Item(s)

per page
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