Macrophage F4/80 antigen antibody

Principal name

Macrophage F4/80 antigen antibody

Alternative names for Macrophage F4/80 antigen antibody

Emr1, Gpf480, Cell surface glycoprotein EMR1, EMR1 hormone receptor

SwissProt ID

Q61549 (Mouse)

Gene ID

13733 (Emr1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rat, Rabbit

Available applications

Frozen Sections (C), Flow Cytometry (F), Paraffin Sections (P), Immunoelectron Microscopy (EM), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R), Western blot / Immunoblot (WB), Functional assay (FN)

Selected product citations ‐ of BM4007

1. Kakehashi H, Nishioku T, Tsukuba T, Kadowaki T, Nakamura S, Yamamoto K. Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E. J Immunol. 2007 Nov 1;179(9):5728-37. PubMed PMID: 17947645.
2. Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, et al. Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood. 2009 May 7;113(19):4810-8. doi: 10.1182/blood-2008-07-170316. Epub 2009 Feb 9. PubMed PMID: 19204325.
3. Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, et al. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2307-12. Epub 2004 Nov 4. PubMed PMID: 15528482.
4. Stangl S, Gehrmann M, Riegger J, Kuhs K, Riederer I, Sievert W, et al. Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):733-8. doi: 10.1073/pnas.1016065108. Epub 2010 Dec 27. PubMed PMID: 21187371. 
5. Rydman, E. Inflammatory effects of nanosized titanium dioxide and carbon nanotube pulmonary exposure. Thesis 2016. https://helda.helsinki.fi/handle/10138/166835. 
6. ISSN 2412-9690 Actualscience 2016, 35-36, Том 2, № 10

Background of Macrophage F4/80 antigen antibody

Mouse EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1) or cell surface glycoprotein F4/80 is a cell surface glycoprotein and a member of the EGF TM7 family of proteins. It shares 68% overall amino acid identity with human EGF-module-containing-mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells.

General readings

1. Austyn JM, Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol. 1981 Oct;11(10):805-15. PubMed PMID: 7308288.
2. Hume DA, Perry VH, Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia. Anat Rec. 1984 Nov;210(3):503-12. PubMed PMID: 6524692.
3. Lee SH, Starkey PM, Gordon S. Quantitative analysis of total macrophage content in adult mouse tissues. Immunochemical studies with monoclonal antibody F4/80. J Exp Med. 1985 Mar 1;161(3):475-89. PubMed PMID: 3973536.
4. Gordon S, Lawson L, Rabinowitz S, Crocker PR, Morris L, Perry VH. Antigen markers of macrophage differentiation in murine tissues. Curr Top Microbiol Immunol. 1992;181:1-37. PubMed PMID: 1424778.
5. Warschkau H, Kiderlen AF. A monoclonal antibody directed against the murine macrophage surface molecule F4/80 modulates natural immune response to Listeria monocytogenes. J Immunol. 1999 Sep 15;163(6):3409-16. PubMed PMID: 10477612.
6. Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, et al. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med. 2005 May 16;201(10):1615-25. Epub 2005 May 9. PubMed PMID: 15883173.
7. Chan, R.J. et al. (2005) Human somatic PTPN11 mutations induce hematopoietic cell hypersensitivity to granulocyte-macrophage colony stimulating factor Blood. 105: 3737-3742.
8. Pizza, F.X. et al. (2005) Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice. J Physiol. 562 (Pt 3): 899-913.
9. Tarallo, V. et al. (2011) The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors. J Biol Chem. 286: 19641-51.
10. Rivollier, A. et al. (2012) Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med. 209: 139-55.
11. Hemmi, H. et al. (2009) A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells. J Immunol. 182:1278-86.
12. Seitz, O. et al. (2010) Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study Exp Diabetes Res. 2010: 476969.
13. Miao, E.A. et al. (2011) Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol. 11: 1136-42.
14. Wang, X. et al. (2011) Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance Endocrinology. 152: 836-46.
15. Cunningham, O. et al. (2009) Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation. Glia. 57: 1802-14.
16. Gornicka, A. et al. (2012) Adipocyte hypertrophy is associated with lysosomal permeability both in vivo and in vitro: role in adipose tissue inflammation. Am J Physiol Endocrinol Metab. 303: E597-606.
17. Akbarshahi, H. et al. (2012) Enrichment of Murine CD68(+)CCR2(+) and CD68(+)CD206(+) Lung Macrophages in Acute Pancreatitis-Associated Acute Lung Injury. PLoS One. 7: e42654.
18. Banda NK et al. (2012) Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. J Immunol. 188 (3): 1469-78.
19. Bonde, A.K. et al. (2012) Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer. 12: 35.
20. Choi, K.M. et al. (2010) CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology. 138 (7): 2399-409, 2409.e1.
21. Tamaki, S. et al. (2013) Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction. PLoS One. 8: e68893.
22. Kihira, Y. et al. (2014) Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like Peptide-1 secretion and reduces adipose tissue inflammation. PLoS One. 9(4):e93856.
23. Chinzei, N. et al. (2015) P21 deficiency delays regeneration of skeletal muscular tissue. PLoS One. 10 (5): e0125765.
24. Sumiyoshi, M. et al. (2015) Antitumor and antimetastatic actions of xanthoangelol and 4-hydroxyderricin isolated from Angelica keiskei roots through the inhibited activation and differentiation of M2 macrophages. Phytomedicine. 22 (7-8): 759-67.
25. Kim, M. et al. (2015) Progression of Alport Kidney Disease in Col4a3 Knock Out Mice Is Independent of Sex or Macrophage Depletion by Clodronate Treatment. PLoS One. 10 (11): e0141231.
26. Nagase, M. et al. (2016) Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. PLoS One. 11 (3): e0150886.
27. Bonaterra, G.A. et al. (2016) Morphological Alterations in Gastrocnemius and Soleus Muscles in Male and Female Mice in a Fibromyalgia Model. PLoS One. 11 (3): e0151116. 28. Lei, B. et al. (2016) Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. Sci Rep. 6: 34834

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4007F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2a BM8 Purified Ms C, F, P
0.2 mg / €390.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No. BM4007F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2a BM8 Aff - Purified Ms C, F, P
0.1 mg / €260.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen (N-term) antibody

Fresh cut mouse liver stained with anti-F4/80 antibody cat.no. AM20312PU-... Rabbit IgG SP115 Purified Hu, Ms, Rt P
0.5 ml / €520.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen (N-term) antibody

Fresh cut mouse liver stained with anti-F4/80 antibody cat.no. AM20312PU-... Rabbit IgG SP115 Purified Ms, Rt P
1 ml / €750.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen (N-term) antibody

Fresh cut mouse liver stained with anti-F4/80 antibody cat.no. AM20312PU-... Rabbit IgG SP115 Purified Hu, Ms, Rt P
0.1 ml / €300.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen (N-term) antibody

Human lung stained with anti-F4/80 antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen (N-term) antibody

Human lung stained with anti-F4/80 antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P
1 ml / €530.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen (N-term) antibody

Human lung stained with anti-F4/80 antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P
0.1 ml / €200.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4007F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2a BM8 Biotin Hu, Ms C, F, P
0.1 mg / €330.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse Spleen Sections stained with Rat anti Mouse F4/80 Antibody Cat.No BM4008 Rat IgG2b Cl:A3-1 Purified Ms C, EM, F, ICC/IF, IP, P, R, WB
0.5 mg / €670.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b CI:A3-1 APC Ms F
100 Tests / €520.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b Cl:A3-1 Biotin Ms C, F, P, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b Cl:A3-1 Biotin Ms C, F, P, WB
0.5 mg / €710.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b CI:A3-1 FITC Ms F
0.1 mg / €440.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b CI:A3-1 FITC Ms F, ICC/IF
50 µg / €290.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b Cl:A3-1 FITC Ms F, ICC/IF
0.5 mg / €710.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b Cl:A3-1 Purified Ms C, F, IP, P, R, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b Cl:A3-1 Low Endotoxin Ms C, F, FN, IP, P, R, WB
0.5 mg / €680.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse anti-Macrophage F4/80 antigen antibody Cat.-No BM4008F (5 µg/ml) on Raw 204.4 cells. Cells were fixed in 1% PFA, permeabilized in 0.25%Triton X 100 in PBS, blocked in 1% BSA in PBS. Rat IgG2b CI:A3-1 PE Ms F, ICC/IF
100 Tests / €490.00
  Acris Antibodies GmbH

Macrophage F4/80 antigen antibody

Mouse Spleen Sections stained with Rat anti Mouse F4/80 Antibody Cat.No BM4008 Rat IgG2b Cl:A3-1 Purified Ms C, EM, F, IP, P, R, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

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