MADD antibody

Principal name

MADD antibody

Alternative names for MADD antibody

MAP kinase-activating death domain protein, RAB3GEP, DENN, IG20, Rab3 GDP/GTP exchange factor

SwissProt ID

O08873 (Rat), Q80U28 (Mouse), Q8WXG6 (Human)

Gene ID

8567 (MADD), 228355 (Madd)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of MADD antibody

MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2 (1). MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87% identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MADD (C-term) antibody

  Rabbit Polyclonal MADD Antibody  
Western blot analysis of MADD in whole cell lysates from the indicated cell lines with MADD antibody at 1:250 dilution. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MADD antibody

  Rabbit polyclonal anti-MADD antibody  
Western blot analysis of extracts from COLO cells, HeLa cells and Jurkat cells, using MADD antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MADD (C-term) antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Testis. Rabbit Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MADD antibody

Immunocytochemical staining of human splenocytes with Rabbit anti Human MADD (SP1241P) Rabbit Purified Hu, Ms ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

MADD antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MADD Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

MADD antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MADD Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

MADD - human gene knockout kit via CRISPR

MADD - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MADD - human gene knockout kit via CRISPR

MADD - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MADD - human gene knockout kit via CRISPR

MADD - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MADD - human gene knockout kit via CRISPR

MADD - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Madd - mouse gene knockout kit via CRISPR

Madd - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Madd - mouse gene knockout kit via CRISPR

Madd - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Madd - mouse gene knockout kit via CRISPR

Madd - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Madd - mouse gene knockout kit via CRISPR

Madd - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MADD overexpression lysate

MADD overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

MADD overexpression lysate

MADD overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MADD (mGFP-tagged)-Human MAP-kinase activating death domain (MADD), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MADD (mGFP-tagged)-Human MAP-kinase activating death domain (MADD), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, MADD (mGFP-tagged)-Human MAP-kinase activating death domain (MADD), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, MADD (mGFP-tagged)-Human MAP-kinase activating death domain (MADD), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, MADD (mGFP-tagged) - Human MAP-kinase activating death domain (MADD), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, MADD (mGFP-tagged) - Human MAP-kinase activating death domain (MADD), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, MADD (mGFP-tagged)-Human MAP-kinase activating death domain (MADD), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, MADD (mGFP-tagged)-Human MAP-kinase activating death domain (MADD), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

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